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Serotonin potentiates dopamine inhibition of ventral tegmental area neurons in vitro.
J Neurophysiol 1996; 76(3):2077-82JN

Abstract

1. The ventral tegmental area (VTA) has been implicated in both the rewarding effects of drugs of abuse and the etiology of schizophrenia. We report here that serotonin (5-HT) potentiates the inhibitory effect of dopamine on dopaminergic VTA neurons. Dopamine (0.5-10 microM) inhibited the spontaneous firing of putative dopamine-containing neurons of the VTA. 5-HT (5-10 microM) itself did not significantly alter the spontaneous firing rate; however, in the presence of 5-HT, the inhibitory potency of dopamine was significantly increased. 2. The inhibitory potency of the dopamine agonist quinpirole was also increased by 5-HT. 3. 5-HT-induced potentiation was also produced by the selective 5-HT2 agonist (+/-)-2,5-dimethoxy-4-iodoamphetamine, and was reversed by the selective 5-HT2 antagonist ketanserin. 4. This novel action of 5-HT on dopaminergic neurons has important implications for the development of drugs to treat schizophrenia, and for the identification of agents that will be useful in treating drug abuse disorders like alcoholism.

Authors+Show Affiliations

Department of Physiology and Biophysics, University of Illinois at Chicago, College of Medicine 60612, USA.No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

8890316

Citation

Brodie, M S., and E B. Bunney. "Serotonin Potentiates Dopamine Inhibition of Ventral Tegmental Area Neurons in Vitro." Journal of Neurophysiology, vol. 76, no. 3, 1996, pp. 2077-82.
Brodie MS, Bunney EB. Serotonin potentiates dopamine inhibition of ventral tegmental area neurons in vitro. J Neurophysiol. 1996;76(3):2077-82.
Brodie, M. S., & Bunney, E. B. (1996). Serotonin potentiates dopamine inhibition of ventral tegmental area neurons in vitro. Journal of Neurophysiology, 76(3), pp. 2077-82.
Brodie MS, Bunney EB. Serotonin Potentiates Dopamine Inhibition of Ventral Tegmental Area Neurons in Vitro. J Neurophysiol. 1996;76(3):2077-82. PubMed PMID: 8890316.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Serotonin potentiates dopamine inhibition of ventral tegmental area neurons in vitro. AU - Brodie,M S, AU - Bunney,E B, PY - 1996/9/1/pubmed PY - 1996/9/1/medline PY - 1996/9/1/entrez SP - 2077 EP - 82 JF - Journal of neurophysiology JO - J. Neurophysiol. VL - 76 IS - 3 N2 - 1. The ventral tegmental area (VTA) has been implicated in both the rewarding effects of drugs of abuse and the etiology of schizophrenia. We report here that serotonin (5-HT) potentiates the inhibitory effect of dopamine on dopaminergic VTA neurons. Dopamine (0.5-10 microM) inhibited the spontaneous firing of putative dopamine-containing neurons of the VTA. 5-HT (5-10 microM) itself did not significantly alter the spontaneous firing rate; however, in the presence of 5-HT, the inhibitory potency of dopamine was significantly increased. 2. The inhibitory potency of the dopamine agonist quinpirole was also increased by 5-HT. 3. 5-HT-induced potentiation was also produced by the selective 5-HT2 agonist (+/-)-2,5-dimethoxy-4-iodoamphetamine, and was reversed by the selective 5-HT2 antagonist ketanserin. 4. This novel action of 5-HT on dopaminergic neurons has important implications for the development of drugs to treat schizophrenia, and for the identification of agents that will be useful in treating drug abuse disorders like alcoholism. SN - 0022-3077 UR - https://www.unboundmedicine.com/medline/citation/8890316/Serotonin_potentiates_dopamine_inhibition_of_ventral_tegmental_area_neurons_in_vitro_ L2 - http://journals.physiology.org/doi/full/10.1152/jn.1996.76.3.2077?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -