Tags

Type your tag names separated by a space and hit enter

Fatty acid composition of lipoprotein lipids in hepatobiliary diseases.
Eur J Clin Chem Clin Biochem 1996; 34(9):701-9EJ

Abstract

Liver damage and alterations in the exocrine function of the gland lead to a profound alteration of the plasma lipoprotein profile. To determine whether hepatic disease results in changes in the lipoprotein fatty acid composition, i.e. to determine whether liver function influences the homeostasis of complex lipids in plasma, we studied the fatty acid profile of lipids from VLDL, LDL and HDL, as well as from total plasma, in thirty-one patients of both sexes with hepatobiliary pathology (compensated liver cirrhosis, uncompensated liver cirrhosis, primary biliary cirrhosis, other intrahepatic cholestasis, and acute viral hepatitis). We also studied a group of healthy adults as controls. We present the lipoprotein profile and the fatty acid composition (myristic C14, palmitic C16, palmitoleic C16: 1, stearic C18, oleic C18: 1, linoleic C18: 2, eicosatrienoic C20: 3 omega 6 and arachidonic C20: 4) of lipoprotein and total plasma triacylglycerols, cholesteryl esters and phospholipids. The main observation of this study is that, despite the profound changes in the lipoprotein profile and the lower abundance of polyunsaturated fatty acids in complex lipids, the composition of all triacylglycerols, cholesteryl esters and phospholipids is very similar for the corresponding lipoproteins of patients with hepatobiliary disease and of control subjects. This indicates that in the controls as in the studied patients, the exchange of lipids between plasmatic lipoproteins is very rapid and demonstrates the possible importance of the extrahepatic synthesis of cholesteryl ester transfer protein.

Authors+Show Affiliations

Servicio de Bioquímica Clínica, Hospital Ramón y Cajal, Madrid, Spain.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8891522

Citation

Arranz, M I., et al. "Fatty Acid Composition of Lipoprotein Lipids in Hepatobiliary Diseases." European Journal of Clinical Chemistry and Clinical Biochemistry : Journal of the Forum of European Clinical Chemistry Societies, vol. 34, no. 9, 1996, pp. 701-9.
Arranz MI, Lasunción MA, Perales J, et al. Fatty acid composition of lipoprotein lipids in hepatobiliary diseases. Eur J Clin Chem Clin Biochem. 1996;34(9):701-9.
Arranz, M. I., Lasunción, M. A., Perales, J., Herrera, E., Lorenzo, I., Cárcamo, C., ... Gasalla, R. (1996). Fatty acid composition of lipoprotein lipids in hepatobiliary diseases. European Journal of Clinical Chemistry and Clinical Biochemistry : Journal of the Forum of European Clinical Chemistry Societies, 34(9), pp. 701-9.
Arranz MI, et al. Fatty Acid Composition of Lipoprotein Lipids in Hepatobiliary Diseases. Eur J Clin Chem Clin Biochem. 1996;34(9):701-9. PubMed PMID: 8891522.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Fatty acid composition of lipoprotein lipids in hepatobiliary diseases. AU - Arranz,M I, AU - Lasunción,M A, AU - Perales,J, AU - Herrera,E, AU - Lorenzo,I, AU - Cárcamo,C, AU - Concostrina,L, AU - Villar,J, AU - Gasalla,R, PY - 1996/9/1/pubmed PY - 1996/9/1/medline PY - 1996/9/1/entrez SP - 701 EP - 9 JF - European journal of clinical chemistry and clinical biochemistry : journal of the Forum of European Clinical Chemistry Societies JO - Eur J Clin Chem Clin Biochem VL - 34 IS - 9 N2 - Liver damage and alterations in the exocrine function of the gland lead to a profound alteration of the plasma lipoprotein profile. To determine whether hepatic disease results in changes in the lipoprotein fatty acid composition, i.e. to determine whether liver function influences the homeostasis of complex lipids in plasma, we studied the fatty acid profile of lipids from VLDL, LDL and HDL, as well as from total plasma, in thirty-one patients of both sexes with hepatobiliary pathology (compensated liver cirrhosis, uncompensated liver cirrhosis, primary biliary cirrhosis, other intrahepatic cholestasis, and acute viral hepatitis). We also studied a group of healthy adults as controls. We present the lipoprotein profile and the fatty acid composition (myristic C14, palmitic C16, palmitoleic C16: 1, stearic C18, oleic C18: 1, linoleic C18: 2, eicosatrienoic C20: 3 omega 6 and arachidonic C20: 4) of lipoprotein and total plasma triacylglycerols, cholesteryl esters and phospholipids. The main observation of this study is that, despite the profound changes in the lipoprotein profile and the lower abundance of polyunsaturated fatty acids in complex lipids, the composition of all triacylglycerols, cholesteryl esters and phospholipids is very similar for the corresponding lipoproteins of patients with hepatobiliary disease and of control subjects. This indicates that in the controls as in the studied patients, the exchange of lipids between plasmatic lipoproteins is very rapid and demonstrates the possible importance of the extrahepatic synthesis of cholesteryl ester transfer protein. SN - 0939-4974 UR - https://www.unboundmedicine.com/medline/citation/8891522/Fatty_acid_composition_of_lipoprotein_lipids_in_hepatobiliary_diseases_ L2 - https://www.lens.org/lens/search?q=citation_id:8891522 DB - PRIME DP - Unbound Medicine ER -