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Increased frequency of IgM antibodies to cow's milk proteins in Hungarian children with newly diagnosed insulin-dependent diabetes mellitus.
Eur J Pediatr. 1996 Oct; 155(10):885-9.EJ

Abstract

We investigated the association between serum antibodies to cow's milk proteins and insulin-dependent diabetes mellitus (IDDM) in Hungarian children. Forty-eight children 1.0-17.1 years of age with newly diagnosed IDDM and 74 control children 1.0-16.0 years of age were studied for serum IgG, IgA and IgM antibodies to cow's milk, beta-lactoglobulin, bovine serum albumin and ovalbumin by enzyme-linked immunosorbent assays. The specificity of IgM antibodies to beta-lactoglobulin and bovine serum albumin was controlled by Western blot. The levels of IgG and IgA antibodies to cow's milk proteins were similar in children with and without IDDM, with the exception of slightly increased levels of IgA antibodies to beta-lactoglobulin in diabetic children (P = 0.05). The levels of IgM antibodies to cow's milk were significantly higher in IDDM patients than in control children (P = 0.0002). Children with IDDM more often had IgM antibodies to beta-lactoglobulin (46.3% vs 18.8%; P = 0.002) and bovine serum albumin (87.8% vs 49.3%, P < 0.0001) than control children. Neither the levels of IgG or IgA antibodies to ovalbumin nor the frequency of IgM antibodies to ovalbumin differed between diabetic and control children.

CONCLUSION

In Hungarian children, clinical manifestation of IDDM is often associated with IgM antibody response to cow's milk protein and its fractions, beta-lactoglobulin and bovine serum albumin, indicating a loss of immunological tolerance to these proteins. IgG and IgA antibodies to cow's milk proteins, associated with an early introduction of cow's milk in diet, seem to play a minor role in the development of childhood IDDM in Hungary.

Authors+Show Affiliations

Children's Hospital, University of Helsinki, Finland.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8891559

Citation

Saukkonen, T, et al. "Increased Frequency of IgM Antibodies to Cow's Milk Proteins in Hungarian Children With Newly Diagnosed Insulin-dependent Diabetes Mellitus." European Journal of Pediatrics, vol. 155, no. 10, 1996, pp. 885-9.
Saukkonen T, Savilahti E, Madácsy L, et al. Increased frequency of IgM antibodies to cow's milk proteins in Hungarian children with newly diagnosed insulin-dependent diabetes mellitus. Eur J Pediatr. 1996;155(10):885-9.
Saukkonen, T., Savilahti, E., Madácsy, L., Arató, A., Körner, A., Barkai, L., Sarnesto, A., & Akerblom, H. K. (1996). Increased frequency of IgM antibodies to cow's milk proteins in Hungarian children with newly diagnosed insulin-dependent diabetes mellitus. European Journal of Pediatrics, 155(10), 885-9.
Saukkonen T, et al. Increased Frequency of IgM Antibodies to Cow's Milk Proteins in Hungarian Children With Newly Diagnosed Insulin-dependent Diabetes Mellitus. Eur J Pediatr. 1996;155(10):885-9. PubMed PMID: 8891559.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Increased frequency of IgM antibodies to cow's milk proteins in Hungarian children with newly diagnosed insulin-dependent diabetes mellitus. AU - Saukkonen,T, AU - Savilahti,E, AU - Madácsy,L, AU - Arató,A, AU - Körner,A, AU - Barkai,L, AU - Sarnesto,A, AU - Akerblom,H K, PY - 1996/10/1/pubmed PY - 1996/10/1/medline PY - 1996/10/1/entrez SP - 885 EP - 9 JF - European journal of pediatrics JO - Eur. J. Pediatr. VL - 155 IS - 10 N2 - UNLABELLED: We investigated the association between serum antibodies to cow's milk proteins and insulin-dependent diabetes mellitus (IDDM) in Hungarian children. Forty-eight children 1.0-17.1 years of age with newly diagnosed IDDM and 74 control children 1.0-16.0 years of age were studied for serum IgG, IgA and IgM antibodies to cow's milk, beta-lactoglobulin, bovine serum albumin and ovalbumin by enzyme-linked immunosorbent assays. The specificity of IgM antibodies to beta-lactoglobulin and bovine serum albumin was controlled by Western blot. The levels of IgG and IgA antibodies to cow's milk proteins were similar in children with and without IDDM, with the exception of slightly increased levels of IgA antibodies to beta-lactoglobulin in diabetic children (P = 0.05). The levels of IgM antibodies to cow's milk were significantly higher in IDDM patients than in control children (P = 0.0002). Children with IDDM more often had IgM antibodies to beta-lactoglobulin (46.3% vs 18.8%; P = 0.002) and bovine serum albumin (87.8% vs 49.3%, P < 0.0001) than control children. Neither the levels of IgG or IgA antibodies to ovalbumin nor the frequency of IgM antibodies to ovalbumin differed between diabetic and control children. CONCLUSION: In Hungarian children, clinical manifestation of IDDM is often associated with IgM antibody response to cow's milk protein and its fractions, beta-lactoglobulin and bovine serum albumin, indicating a loss of immunological tolerance to these proteins. IgG and IgA antibodies to cow's milk proteins, associated with an early introduction of cow's milk in diet, seem to play a minor role in the development of childhood IDDM in Hungary. SN - 0340-6199 UR - https://www.unboundmedicine.com/medline/citation/8891559/Increased_frequency_of_IgM_antibodies_to_cow's_milk_proteins_in_Hungarian_children_with_newly_diagnosed_insulin_dependent_diabetes_mellitus_ L2 - https://dx.doi.org/10.1007/bf02282839 DB - PRIME DP - Unbound Medicine ER -