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Outcome of long-term treatment with the 5 alpha-reductase inhibitor finasteride in idiopathic hirsutism: clinical and hormonal effects during a 1-year course of therapy and 1-year follow-up.
Fertil Steril. 1996 Nov; 66(5):734-40.FS

Abstract

OBJECTIVE

To evaluate the long-term efficacy of the 5 alpha-reductase inhibitor finasteride in idiopathic hirsutism.

DESIGN

Prospective clinical study.

SETTING

Outpatients in a university hospital.

PATIENT(S)

Fourteen young women with idiopathic hirsutism.

INTERVENTION(S)

Finasteride, 5 mg once daily, was given for 12 months.

MAIN OUTCOME MEASURE(S)

Degree of hirsutism, graded by a modified Ferriman and Gallwey score, serum sex hormones, and serum and urinary markers of 5 alpha-reductase activity. Clinical outcome was evaluated up to and including the 1-year post-treatment period.

RESULT(S)

The Ferriman and Gallwey score showed a remarkable reduction after 12 months of finasteride treatment (4.4 +/- 0.7 versus 11.8 +/- 1.0; mean +/- SEM). Serum levels of the two 5 alpha-reductase activity markers, dihydrotestosterone and 3 alpha-androstanediol glucuronide, decreased, and urinary C19 and C21 5 beta:5 alpha steroid metabolite ratios consistently increased during finasteride administration. These changes were reversed readily after cessation of treatment. No significant adverse effect was reported. Nine of 14 women completed the 1-year post-treatment follow-up. Their hirsutism scores were increased substantially as compared with values recorded at the end of therapy, but still were lower than baseline values.

CONCLUSION(S)

The 5 alpha-reductase inhibitor finasteride is effective and well tolerated in longterm treatment of women with idiopathic hirsutism. Post-treatment follow-up suggests that drug effects on hair growth are sustained in the majority of subjects with this disorder.

Authors+Show Affiliations

Castello R
Divisione Clinicizzata di Endocrinologia e Malattie del Metabolismo, University of Verona, Italy.
Tosi F
No affiliation info available
Perrone F
No affiliation info available
Negri C
No affiliation info available
Muggeo M
No affiliation info available
Moghetti P
No affiliation info available

MeSH

5-alpha Reductase InhibitorsAdultAndrostane-3,17-diolDihydrotestosteroneEnzyme InhibitorsFemaleFinasterideHirsutismHumansLuteinizing HormoneTestosteroneTreatment Outcome

Pub Type(s)

Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8893676

Citation

Castello, R, et al. "Outcome of Long-term Treatment With the 5 Alpha-reductase Inhibitor Finasteride in Idiopathic Hirsutism: Clinical and Hormonal Effects During a 1-year Course of Therapy and 1-year Follow-up." Fertility and Sterility, vol. 66, no. 5, 1996, pp. 734-40.
Castello R, Tosi F, Perrone F, et al. Outcome of long-term treatment with the 5 alpha-reductase inhibitor finasteride in idiopathic hirsutism: clinical and hormonal effects during a 1-year course of therapy and 1-year follow-up. Fertil Steril. 1996;66(5):734-40.
Castello, R., Tosi, F., Perrone, F., Negri, C., Muggeo, M., & Moghetti, P. (1996). Outcome of long-term treatment with the 5 alpha-reductase inhibitor finasteride in idiopathic hirsutism: clinical and hormonal effects during a 1-year course of therapy and 1-year follow-up. Fertility and Sterility, 66(5), 734-40.
Castello R, et al. Outcome of Long-term Treatment With the 5 Alpha-reductase Inhibitor Finasteride in Idiopathic Hirsutism: Clinical and Hormonal Effects During a 1-year Course of Therapy and 1-year Follow-up. Fertil Steril. 1996;66(5):734-40. PubMed PMID: 8893676.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Outcome of long-term treatment with the 5 alpha-reductase inhibitor finasteride in idiopathic hirsutism: clinical and hormonal effects during a 1-year course of therapy and 1-year follow-up. AU - Castello,R, AU - Tosi,F, AU - Perrone,F, AU - Negri,C, AU - Muggeo,M, AU - Moghetti,P, PY - 1996/11/1/pubmed PY - 1996/11/1/medline PY - 1996/11/1/entrez SP - 734 EP - 40 JF - Fertility and sterility JO - Fertil Steril VL - 66 IS - 5 N2 - OBJECTIVE: To evaluate the long-term efficacy of the 5 alpha-reductase inhibitor finasteride in idiopathic hirsutism. DESIGN: Prospective clinical study. SETTING: Outpatients in a university hospital. PATIENT(S): Fourteen young women with idiopathic hirsutism. INTERVENTION(S): Finasteride, 5 mg once daily, was given for 12 months. MAIN OUTCOME MEASURE(S): Degree of hirsutism, graded by a modified Ferriman and Gallwey score, serum sex hormones, and serum and urinary markers of 5 alpha-reductase activity. Clinical outcome was evaluated up to and including the 1-year post-treatment period. RESULT(S): The Ferriman and Gallwey score showed a remarkable reduction after 12 months of finasteride treatment (4.4 +/- 0.7 versus 11.8 +/- 1.0; mean +/- SEM). Serum levels of the two 5 alpha-reductase activity markers, dihydrotestosterone and 3 alpha-androstanediol glucuronide, decreased, and urinary C19 and C21 5 beta:5 alpha steroid metabolite ratios consistently increased during finasteride administration. These changes were reversed readily after cessation of treatment. No significant adverse effect was reported. Nine of 14 women completed the 1-year post-treatment follow-up. Their hirsutism scores were increased substantially as compared with values recorded at the end of therapy, but still were lower than baseline values. CONCLUSION(S): The 5 alpha-reductase inhibitor finasteride is effective and well tolerated in longterm treatment of women with idiopathic hirsutism. Post-treatment follow-up suggests that drug effects on hair growth are sustained in the majority of subjects with this disorder. SN - 0015-0282 UR - https://www.unboundmedicine.com/medline/citation/8893676/Outcome_of_long_term_treatment_with_the_5_alpha_reductase_inhibitor_finasteride_in_idiopathic_hirsutism:_clinical_and_hormonal_effects_during_a_1_year_course_of_therapy_and_1_year_follow_up_ DB - PRIME DP - Unbound Medicine ER -