Tags

Type your tag names separated by a space and hit enter

Lack of effect of delta F508 mutation on aerobic capacity in patients with cystic fibrosis.
Clin J Sport Med 1996; 6(4):226-31CJ

Abstract

OBJECTIVE

As aerobic exercise capacity, as defined by VO2max, is associated with patient functioning and possibly prognosis in cystic fibrosis (CF), correlations between VO2max phenotype and genotype may be of value.

DESIGN

Retrospective clinical series.

SETTING

Cystic fibrosis referral clinic.

PATIENTS

Convenience sample of 35 patients with CF consecutively referred for exercise testing.

MAIN OUTCOME MEASURES

Blood samples were examined for mutations of cystic fibrosis transmembrane regulator (CFTR), Height, wight, pulmonary function, resting-energy expenditure, VO2max, and other exercise variables were assessed in each referred patient.

RESULTS

Statistical comparison of 10 patients who were homozygous for the dF508 mutation of CFTR with 20 patients heterozygous for dF508 revealed no significant differences for height, weight, pulmonary function, resting-energy expenditure, VO2max, or any other exercise variables.

CONCLUSIONS

These results imply a limited effect of the mutation status on overall patient functioning and prognosis. Future identification of more rare CFTR mutations and other genes and subsequent classification of patients in a manner reflective of the cellular physiology may lead to different results.

Authors+Show Affiliations

Department of Pediatrics, University of Miami School of Medicine, Florida, USA.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

8894334

Citation

Kaplan, T A., et al. "Lack of Effect of Delta F508 Mutation On Aerobic Capacity in Patients With Cystic Fibrosis." Clinical Journal of Sport Medicine : Official Journal of the Canadian Academy of Sport Medicine, vol. 6, no. 4, 1996, pp. 226-31.
Kaplan TA, Moccia-Loos G, Rabin M, et al. Lack of effect of delta F508 mutation on aerobic capacity in patients with cystic fibrosis. Clin J Sport Med. 1996;6(4):226-31.
Kaplan, T. A., Moccia-Loos, G., Rabin, M., & McKey, R. M. (1996). Lack of effect of delta F508 mutation on aerobic capacity in patients with cystic fibrosis. Clinical Journal of Sport Medicine : Official Journal of the Canadian Academy of Sport Medicine, 6(4), pp. 226-31.
Kaplan TA, et al. Lack of Effect of Delta F508 Mutation On Aerobic Capacity in Patients With Cystic Fibrosis. Clin J Sport Med. 1996;6(4):226-31. PubMed PMID: 8894334.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Lack of effect of delta F508 mutation on aerobic capacity in patients with cystic fibrosis. AU - Kaplan,T A, AU - Moccia-Loos,G, AU - Rabin,M, AU - McKey,R M,Jr PY - 1996/10/1/pubmed PY - 2001/3/28/medline PY - 1996/10/1/entrez SP - 226 EP - 31 JF - Clinical journal of sport medicine : official journal of the Canadian Academy of Sport Medicine JO - Clin J Sport Med VL - 6 IS - 4 N2 - OBJECTIVE: As aerobic exercise capacity, as defined by VO2max, is associated with patient functioning and possibly prognosis in cystic fibrosis (CF), correlations between VO2max phenotype and genotype may be of value. DESIGN: Retrospective clinical series. SETTING: Cystic fibrosis referral clinic. PATIENTS: Convenience sample of 35 patients with CF consecutively referred for exercise testing. MAIN OUTCOME MEASURES: Blood samples were examined for mutations of cystic fibrosis transmembrane regulator (CFTR), Height, wight, pulmonary function, resting-energy expenditure, VO2max, and other exercise variables were assessed in each referred patient. RESULTS: Statistical comparison of 10 patients who were homozygous for the dF508 mutation of CFTR with 20 patients heterozygous for dF508 revealed no significant differences for height, weight, pulmonary function, resting-energy expenditure, VO2max, or any other exercise variables. CONCLUSIONS: These results imply a limited effect of the mutation status on overall patient functioning and prognosis. Future identification of more rare CFTR mutations and other genes and subsequent classification of patients in a manner reflective of the cellular physiology may lead to different results. SN - 1050-642X UR - https://www.unboundmedicine.com/medline/citation/8894334/Lack_of_effect_of_delta_F508_mutation_on_aerobic_capacity_in_patients_with_cystic_fibrosis_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=8894334.ui DB - PRIME DP - Unbound Medicine ER -