Tags

Type your tag names separated by a space and hit enter

A prospective study of health check examinees for the development of non-insulin-dependent diabetes mellitus: relationship of the incidence of diabetes with the initial insulinogenic index and degree of obesity.
Diabet Med 1996; 13(9 Suppl 6):S120-6DM

Abstract

A total of 1788 non-diabetic subjects, screened by a general health check, had either glycosuria or marginal elevation of fasting blood glucose and/or HbA1c. They were followed by repeated 100 g oral glucose tolerance tests for up to 8 years. Their initial mean age was 52 years and the mean BMI was 23.2. Low insulin secretory response was defined when the insulinogenic index, a ratio of increment of plasma insulin to that of plasma glucose 30 min after oral glucose load, was lower than 0.5. Cumulative incidence of diabetes with fasting blood glucose (FBG) exceeding 120 mg dl-1 was significantly higher in impaired glucose tolerance (IGT) than in non-IGT, and in each of IGT and non-IGT groups, the incidence was significantly higher for low than normal insulin responders. The mean initial plasma insulin response in subjects who developed diabetes was significantly lower than in those who remained non-diabetic with the same category of glucose tolerance at baseline irrespective of the degree of glucose intolerance. The mean baseline BMI did not differ whether or not they developed diabetes, but a few cases who developed diabetes despite normal initial insulin response were much more obese. Fasting insulin levels did not correlate with FBG during the course of development of diabetes. We suggest that defective insulin secretion plays a predominant role in the non-obese subtype of NIDDM which includes the majority of Japanese patients, while both insulin resistance and insulin secretory defect are important in the obese subtype for the development of diabetes.

Authors+Show Affiliations

Toranomon Hospital, Tokyo, Japan.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

8894495

Citation

Kosaka, K, et al. "A Prospective Study of Health Check Examinees for the Development of Non-insulin-dependent Diabetes Mellitus: Relationship of the Incidence of Diabetes With the Initial Insulinogenic Index and Degree of Obesity." Diabetic Medicine : a Journal of the British Diabetic Association, vol. 13, no. 9 Suppl 6, 1996, pp. S120-6.
Kosaka K, Kuzuya T, Yoshinaga H, et al. A prospective study of health check examinees for the development of non-insulin-dependent diabetes mellitus: relationship of the incidence of diabetes with the initial insulinogenic index and degree of obesity. Diabet Med. 1996;13(9 Suppl 6):S120-6.
Kosaka, K., Kuzuya, T., Yoshinaga, H., & Hagura, R. (1996). A prospective study of health check examinees for the development of non-insulin-dependent diabetes mellitus: relationship of the incidence of diabetes with the initial insulinogenic index and degree of obesity. Diabetic Medicine : a Journal of the British Diabetic Association, 13(9 Suppl 6), pp. S120-6.
Kosaka K, et al. A Prospective Study of Health Check Examinees for the Development of Non-insulin-dependent Diabetes Mellitus: Relationship of the Incidence of Diabetes With the Initial Insulinogenic Index and Degree of Obesity. Diabet Med. 1996;13(9 Suppl 6):S120-6. PubMed PMID: 8894495.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A prospective study of health check examinees for the development of non-insulin-dependent diabetes mellitus: relationship of the incidence of diabetes with the initial insulinogenic index and degree of obesity. AU - Kosaka,K, AU - Kuzuya,T, AU - Yoshinaga,H, AU - Hagura,R, PY - 1996/9/1/pubmed PY - 1996/9/1/medline PY - 1996/9/1/entrez SP - S120 EP - 6 JF - Diabetic medicine : a journal of the British Diabetic Association JO - Diabet. Med. VL - 13 IS - 9 Suppl 6 N2 - A total of 1788 non-diabetic subjects, screened by a general health check, had either glycosuria or marginal elevation of fasting blood glucose and/or HbA1c. They were followed by repeated 100 g oral glucose tolerance tests for up to 8 years. Their initial mean age was 52 years and the mean BMI was 23.2. Low insulin secretory response was defined when the insulinogenic index, a ratio of increment of plasma insulin to that of plasma glucose 30 min after oral glucose load, was lower than 0.5. Cumulative incidence of diabetes with fasting blood glucose (FBG) exceeding 120 mg dl-1 was significantly higher in impaired glucose tolerance (IGT) than in non-IGT, and in each of IGT and non-IGT groups, the incidence was significantly higher for low than normal insulin responders. The mean initial plasma insulin response in subjects who developed diabetes was significantly lower than in those who remained non-diabetic with the same category of glucose tolerance at baseline irrespective of the degree of glucose intolerance. The mean baseline BMI did not differ whether or not they developed diabetes, but a few cases who developed diabetes despite normal initial insulin response were much more obese. Fasting insulin levels did not correlate with FBG during the course of development of diabetes. We suggest that defective insulin secretion plays a predominant role in the non-obese subtype of NIDDM which includes the majority of Japanese patients, while both insulin resistance and insulin secretory defect are important in the obese subtype for the development of diabetes. SN - 0742-3071 UR - https://www.unboundmedicine.com/medline/citation/8894495/A_prospective_study_of_health_check_examinees_for_the_development_of_non_insulin_dependent_diabetes_mellitus:_relationship_of_the_incidence_of_diabetes_with_the_initial_insulinogenic_index_and_degree_of_obesity_ L2 - http://www.diseaseinfosearch.org/result/2236 DB - PRIME DP - Unbound Medicine ER -