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Effects on acne of two oral contraceptives containing desogestrel and cyproterone acetate.
Int J Fertil Menopausal Stud. 1996 Jul-Aug; 41(4):423-9.IJ

Abstract

OBJECTIVE

To compare the effects of a low-dose oral contraceptive containing desogestrel (Marvelon) and an anti-androgenic preparation containing cyproterone acetate (Diane) in Oriental women suffering from acne.

METHODS

In an open-label, bi-center, randomized study, 32 women using Marvelon and 34 using Diane were followed for 6 treatment cycles. The measured variables were objective and subjective severity of acne, and related biochemical variables such as sex hormone-binding globulin and free and total testosterone.

RESULTS

In Center A, with both preparations a decrease in mean objective acne score was observed, reaching statistical significance with Diane (P < .05). In addition, there was a significant between group difference at cycle 6 (P < .05). In Center B, a consistent and significant decrease in mean acne score was observed with Marvelon after three and six treatment cycles (P < .05 and P < .01) and with Diane after six treatment cycles (P < .001). There were no significant between-group differences. The decrease in percentage of severe/moderate acne was statistically significant with Marvelon in Center B (P = 0.002) and with Diane in Centers A (P = 0.014) and B (P = 0.004). Both preparations increased plasma levels of sex hormone binding globulin and seemed to decrease those of total and free testosterone, but no statistically significant relationships between acne severity and biochemical variables could be detected.

CONCLUSION

Both Marvelon and Diane are effective in the treatment of acne in Oriental women who also need reliable contraception, without marked differences between the preparations.

Authors+Show Affiliations

Department of Obstetrics and Gynecology, Faculty of Medicine, Prince of Songkhla University, Thailand.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Multicenter Study
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8894800

Citation

Charoenvisal, C, et al. "Effects On Acne of Two Oral Contraceptives Containing Desogestrel and Cyproterone Acetate." International Journal of Fertility and Menopausal Studies, vol. 41, no. 4, 1996, pp. 423-9.
Charoenvisal C, Thaipisuttikul Y, Pinjaroen S, et al. Effects on acne of two oral contraceptives containing desogestrel and cyproterone acetate. Int J Fertil Menopausal Stud. 1996;41(4):423-9.
Charoenvisal, C., Thaipisuttikul, Y., Pinjaroen, S., Krisanapan, O., Benjawang, W., Koster, A., & Doesburg, W. (1996). Effects on acne of two oral contraceptives containing desogestrel and cyproterone acetate. International Journal of Fertility and Menopausal Studies, 41(4), 423-9.
Charoenvisal C, et al. Effects On Acne of Two Oral Contraceptives Containing Desogestrel and Cyproterone Acetate. Int J Fertil Menopausal Stud. 1996 Jul-Aug;41(4):423-9. PubMed PMID: 8894800.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects on acne of two oral contraceptives containing desogestrel and cyproterone acetate. AU - Charoenvisal,C, AU - Thaipisuttikul,Y, AU - Pinjaroen,S, AU - Krisanapan,O, AU - Benjawang,W, AU - Koster,A, AU - Doesburg,W, PY - 1996/7/1/pubmed PY - 1996/7/1/medline PY - 1996/7/1/entrez KW - Acne KW - Androgens KW - Asia KW - Biology KW - Comparative Studies KW - Contraception KW - Contraceptive Agents KW - Contraceptive Agents, Female KW - Contraceptive Agents, Progestin KW - Contraceptive Methods--therapeutic use KW - Cyproterone Acetate KW - Dermatitis KW - Desogestrel KW - Developing Countries KW - Diseases KW - Endocrine System KW - Family Planning KW - Hormone Antagonists KW - Hormones KW - Oral Contraceptives, Combined--therapeutic use KW - Oral Contraceptives--therapeutic use KW - Physiology KW - Research Methodology KW - Research Report KW - Southeastern Asia KW - Studies KW - Testosterone KW - Thailand KW - Treatment SP - 423 EP - 9 JF - International journal of fertility and menopausal studies JO - Int J Fertil Menopausal Stud VL - 41 IS - 4 N2 - OBJECTIVE: To compare the effects of a low-dose oral contraceptive containing desogestrel (Marvelon) and an anti-androgenic preparation containing cyproterone acetate (Diane) in Oriental women suffering from acne. METHODS: In an open-label, bi-center, randomized study, 32 women using Marvelon and 34 using Diane were followed for 6 treatment cycles. The measured variables were objective and subjective severity of acne, and related biochemical variables such as sex hormone-binding globulin and free and total testosterone. RESULTS: In Center A, with both preparations a decrease in mean objective acne score was observed, reaching statistical significance with Diane (P < .05). In addition, there was a significant between group difference at cycle 6 (P < .05). In Center B, a consistent and significant decrease in mean acne score was observed with Marvelon after three and six treatment cycles (P < .05 and P < .01) and with Diane after six treatment cycles (P < .001). There were no significant between-group differences. The decrease in percentage of severe/moderate acne was statistically significant with Marvelon in Center B (P = 0.002) and with Diane in Centers A (P = 0.014) and B (P = 0.004). Both preparations increased plasma levels of sex hormone binding globulin and seemed to decrease those of total and free testosterone, but no statistically significant relationships between acne severity and biochemical variables could be detected. CONCLUSION: Both Marvelon and Diane are effective in the treatment of acne in Oriental women who also need reliable contraception, without marked differences between the preparations. SN - 1069-3130 UR - https://www.unboundmedicine.com/medline/citation/8894800/Effects_on_acne_of_two_oral_contraceptives_containing_desogestrel_and_cyproterone_acetate_ L2 - https://medlineplus.gov/acne.html DB - PRIME DP - Unbound Medicine ER -