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A comparison of cisatracurium and atracurium: onset of neuromuscular block after bolus injection and recovery after subsequent infusion.
Anesth Analg. 1996 Nov; 83(5):1072-5.A&A

Abstract

Cisatracurium is a new nondepolarizing muscle relaxant. In patients randomized to receive either cisatracurium (n = 40) or atracurium (n = 20) we compared the time course of neuromuscular block. The initial bolus dose of cisatracurium was 0.1 mg/kg, that of atracurium 0.5 mg/kg. Neuromuscular block, maintained with an infusion of either drug, was reversed with neostigmine 45 micrograms/kg and atropine 20 micrograms/kg in one half of the patients. Neuromuscular transmission was assessed by recording the mechanical twitch response to train-of-four nerve stimulation. Onset times were 3.1 +/- 1.0 min with cisatracurium and 2.3 +/- 1.1 min with atracurium (P = 0.008). The infusion rates for a 95% +/- 4% neuromuscular block were 1.5 +/- 0.4 micrograms.kg-1.min-1 for cisatracurium and 6.6 +/- 1.7 micrograms.kg-1.min-1 for atracurium, 3.3 times those of cisatracurium when referenced to the active cations. After the infusion, the spontaneous recovery intervals 25%-75% of 18 +/- 11 min and 18 +/- 8 min for cisatracurium and atracurium (P = 0.896) were shortened to 5 +/- 2 min and 4 +/- 3 min (P = 0.921) after neostigmine. While attributing different onset times also to differences in the initial doses, we conclude that time profiles for neuromuscular block of both muscle relaxants, when given in equipotent doses, are not different.

Authors+Show Affiliations

Department of Anesthesiology, University of Cologne, Germany.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8895288

Citation

Mellinghoff, H, et al. "A Comparison of Cisatracurium and Atracurium: Onset of Neuromuscular Block After Bolus Injection and Recovery After Subsequent Infusion." Anesthesia and Analgesia, vol. 83, no. 5, 1996, pp. 1072-5.
Mellinghoff H, Radbruch L, Diefenbach C, et al. A comparison of cisatracurium and atracurium: onset of neuromuscular block after bolus injection and recovery after subsequent infusion. Anesth Analg. 1996;83(5):1072-5.
Mellinghoff, H., Radbruch, L., Diefenbach, C., & Buzello, W. (1996). A comparison of cisatracurium and atracurium: onset of neuromuscular block after bolus injection and recovery after subsequent infusion. Anesthesia and Analgesia, 83(5), 1072-5.
Mellinghoff H, et al. A Comparison of Cisatracurium and Atracurium: Onset of Neuromuscular Block After Bolus Injection and Recovery After Subsequent Infusion. Anesth Analg. 1996;83(5):1072-5. PubMed PMID: 8895288.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A comparison of cisatracurium and atracurium: onset of neuromuscular block after bolus injection and recovery after subsequent infusion. AU - Mellinghoff,H, AU - Radbruch,L, AU - Diefenbach,C, AU - Buzello,W, PY - 1996/11/1/pubmed PY - 1996/11/1/medline PY - 1996/11/1/entrez SP - 1072 EP - 5 JF - Anesthesia and analgesia JO - Anesth Analg VL - 83 IS - 5 N2 - Cisatracurium is a new nondepolarizing muscle relaxant. In patients randomized to receive either cisatracurium (n = 40) or atracurium (n = 20) we compared the time course of neuromuscular block. The initial bolus dose of cisatracurium was 0.1 mg/kg, that of atracurium 0.5 mg/kg. Neuromuscular block, maintained with an infusion of either drug, was reversed with neostigmine 45 micrograms/kg and atropine 20 micrograms/kg in one half of the patients. Neuromuscular transmission was assessed by recording the mechanical twitch response to train-of-four nerve stimulation. Onset times were 3.1 +/- 1.0 min with cisatracurium and 2.3 +/- 1.1 min with atracurium (P = 0.008). The infusion rates for a 95% +/- 4% neuromuscular block were 1.5 +/- 0.4 micrograms.kg-1.min-1 for cisatracurium and 6.6 +/- 1.7 micrograms.kg-1.min-1 for atracurium, 3.3 times those of cisatracurium when referenced to the active cations. After the infusion, the spontaneous recovery intervals 25%-75% of 18 +/- 11 min and 18 +/- 8 min for cisatracurium and atracurium (P = 0.896) were shortened to 5 +/- 2 min and 4 +/- 3 min (P = 0.921) after neostigmine. While attributing different onset times also to differences in the initial doses, we conclude that time profiles for neuromuscular block of both muscle relaxants, when given in equipotent doses, are not different. SN - 0003-2999 UR - https://www.unboundmedicine.com/medline/citation/8895288/A_comparison_of_cisatracurium_and_atracurium:_onset_of_neuromuscular_block_after_bolus_injection_and_recovery_after_subsequent_infusion_ L2 - https://doi.org/10.1097/00000539-199611000-00030 DB - PRIME DP - Unbound Medicine ER -