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Gastro-oesophageal reflux during 3 months of therapy with ranitidine in reflux oesophagitis.
Scand J Gastroenterol 1996; 31(10):954-8SJ

Abstract

BACKGROUND

Tolerance has been shown to develop in duodenal ulcer patients receiving H2-receptor antagonists, particularly with increased doses. Development of tolerance to ranitidine and its possible consequences for oesophageal acid load in patients with gastro-oesophageal reflux disease has still to be established.

METHODS

Eighteen patients with reflux oesophagitis grade 1 were treated with 300 mg ranitidine twice daily for 3 months and examined with two-channel 23-h pH-metry in the distal oesophagus and gastric body at base line and after 3 days and 3 months. Gastric infection with Helicobacter pylori was assessed with the 14C urea breath test.

RESULTS

Median 23-h gastric pH increased significantly from 1.5 at base line to 3.7 on day 3 and 2.8 after 3 months but decrease significantly from day 3 to month 3 of therapy. Median 23-h acid reflux time was reduced significantly by therapy, from 12.6% at base line to 6.2% on day 3 and 7.2% after 3 months, and there was no significant difference between day 3 and month 3. Although there was no significant change in commonly used indicators of gastro-oesophageal reflux, interindividual variation was great, and multiple linear regression analysis indicated that tolerance, expressed as change in median gastric pH, was related to individual changes in 23-h acid reflux time with a correlation coefficient of -0.43. Infection with H. pylori was diagnosed in 44% of patients and was negatively related to tolerance.

CONCLUSIONS

Our group of patients developed tolerance to the effect of ranitidine on gastric acidity. While gastro-oesophageal reflux did not change significantly in the group, tolerance may seen to contribute to increased gastro-oesophageal reflux in individual patients.

Authors+Show Affiliations

Medical Dept. A, Haukeland Sykehus, University of Bergen, Norway.No affiliation info available

Pub Type(s)

Clinical Trial
Journal Article

Language

eng

PubMed ID

8898414

Citation

Hatlebakk, J G., and A Berstad. "Gastro-oesophageal Reflux During 3 Months of Therapy With Ranitidine in Reflux Oesophagitis." Scandinavian Journal of Gastroenterology, vol. 31, no. 10, 1996, pp. 954-8.
Hatlebakk JG, Berstad A. Gastro-oesophageal reflux during 3 months of therapy with ranitidine in reflux oesophagitis. Scand J Gastroenterol. 1996;31(10):954-8.
Hatlebakk, J. G., & Berstad, A. (1996). Gastro-oesophageal reflux during 3 months of therapy with ranitidine in reflux oesophagitis. Scandinavian Journal of Gastroenterology, 31(10), pp. 954-8.
Hatlebakk JG, Berstad A. Gastro-oesophageal Reflux During 3 Months of Therapy With Ranitidine in Reflux Oesophagitis. Scand J Gastroenterol. 1996;31(10):954-8. PubMed PMID: 8898414.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Gastro-oesophageal reflux during 3 months of therapy with ranitidine in reflux oesophagitis. AU - Hatlebakk,J G, AU - Berstad,A, PY - 1996/10/1/pubmed PY - 1996/10/1/medline PY - 1996/10/1/entrez SP - 954 EP - 8 JF - Scandinavian journal of gastroenterology JO - Scand. J. Gastroenterol. VL - 31 IS - 10 N2 - BACKGROUND: Tolerance has been shown to develop in duodenal ulcer patients receiving H2-receptor antagonists, particularly with increased doses. Development of tolerance to ranitidine and its possible consequences for oesophageal acid load in patients with gastro-oesophageal reflux disease has still to be established. METHODS: Eighteen patients with reflux oesophagitis grade 1 were treated with 300 mg ranitidine twice daily for 3 months and examined with two-channel 23-h pH-metry in the distal oesophagus and gastric body at base line and after 3 days and 3 months. Gastric infection with Helicobacter pylori was assessed with the 14C urea breath test. RESULTS: Median 23-h gastric pH increased significantly from 1.5 at base line to 3.7 on day 3 and 2.8 after 3 months but decrease significantly from day 3 to month 3 of therapy. Median 23-h acid reflux time was reduced significantly by therapy, from 12.6% at base line to 6.2% on day 3 and 7.2% after 3 months, and there was no significant difference between day 3 and month 3. Although there was no significant change in commonly used indicators of gastro-oesophageal reflux, interindividual variation was great, and multiple linear regression analysis indicated that tolerance, expressed as change in median gastric pH, was related to individual changes in 23-h acid reflux time with a correlation coefficient of -0.43. Infection with H. pylori was diagnosed in 44% of patients and was negatively related to tolerance. CONCLUSIONS: Our group of patients developed tolerance to the effect of ranitidine on gastric acidity. While gastro-oesophageal reflux did not change significantly in the group, tolerance may seen to contribute to increased gastro-oesophageal reflux in individual patients. SN - 0036-5521 UR - https://www.unboundmedicine.com/medline/citation/8898414/Gastro_oesophageal_reflux_during_3_months_of_therapy_with_ranitidine_in_reflux_oesophagitis_ L2 - http://www.tandfonline.com/doi/full/10.3109/00365529609003113 DB - PRIME DP - Unbound Medicine ER -