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Resistance to activated protein C, associated with oral contraceptives use; effect of formulations, duration of assumption, and doses of oestro-progestins.
Contraception. 1996 Sep; 54(3):149-52.C

Abstract

Resistance to activated protein C (APC-R) is at present considered the most frequent laboratory abnormality in patients with deep vein thrombosis. An increased risk for venous thrombosis is associated with the use of oral contraceptives (OCs). We recently described a statistically significant association between APC-R status and oral contraceptives use in a healthy group of women. We re-evaluated 50 healthy women taking low-dose combination OCs in order to consider a possible correlation between the APC sensitivity ratio (APC-SR) and different oral contraceptive formulations. Seven women showed an APC ratio < or = 2 (APC-resistant). Only one of the seven women was found to be heterozygous for Leiden factor V mutation. We observed no significant differences between normally sensitive and APC-resistant women in terms of duration of OC use, amount of estrogenic or progestogenic dose, or type of formulation. We conclude that APC-resistance associated with oral contraceptives use seems to occur only in predisposed subjects (in our results, about 12% of the healthy population).

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Authors+Show Affiliations

Olivieri O
Institute of Medical Pathology, University of Verona, Italy.
Friso S
No affiliation info available
Manzato F
No affiliation info available
Grazioli S
No affiliation info available
Bernardi F
No affiliation info available
Lunghi B
No affiliation info available
Girelli D
No affiliation info available
Azzini M
No affiliation info available
Brocco G
No affiliation info available
Russo C
No affiliation info available
Corrocher R
No affiliation info available

MeSH

AdolescentAdultAnticoagulantsBlood Coagulation DisordersCohort StudiesContraceptives, Oral, HormonalEnzyme ActivationFactor VFemaleHumansMutationProtein CSensitivity and SpecificityThrombophlebitisTime Factors

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8899255

Citation

Olivieri, O, et al. "Resistance to Activated Protein C, Associated With Oral Contraceptives Use; Effect of Formulations, Duration of Assumption, and Doses of Oestro-progestins." Contraception, vol. 54, no. 3, 1996, pp. 149-52.
Olivieri O, Friso S, Manzato F, et al. Resistance to activated protein C, associated with oral contraceptives use; effect of formulations, duration of assumption, and doses of oestro-progestins. Contraception. 1996;54(3):149-52.
Olivieri, O., Friso, S., Manzato, F., Grazioli, S., Bernardi, F., Lunghi, B., Girelli, D., Azzini, M., Brocco, G., Russo, C., & Corrocher, R. (1996). Resistance to activated protein C, associated with oral contraceptives use; effect of formulations, duration of assumption, and doses of oestro-progestins. Contraception, 54(3), 149-52.
Olivieri O, et al. Resistance to Activated Protein C, Associated With Oral Contraceptives Use; Effect of Formulations, Duration of Assumption, and Doses of Oestro-progestins. Contraception. 1996;54(3):149-52. PubMed PMID: 8899255.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Resistance to activated protein C, associated with oral contraceptives use; effect of formulations, duration of assumption, and doses of oestro-progestins. AU - Olivieri,O, AU - Friso,S, AU - Manzato,F, AU - Grazioli,S, AU - Bernardi,F, AU - Lunghi,B, AU - Girelli,D, AU - Azzini,M, AU - Brocco,G, AU - Russo,C, AU - Corrocher,R, PY - 1996/9/1/pubmed PY - 1996/9/1/medline PY - 1996/9/1/entrez KW - Biology KW - Blood Coagulation Effects KW - Contraception KW - Contraceptive Methods--side effects KW - Developed Countries KW - Diseases KW - Embolism KW - Europe KW - Family Planning KW - Hematological Effects KW - Hemic System KW - Italy KW - Mediterranean Countries KW - Oral Contraceptives, Combined--side effects KW - Oral Contraceptives, Low-dose--side effects KW - Oral Contraceptives--side effects KW - Physiology KW - Research Methodology KW - Research Report KW - Retrospective Studies KW - Southern Europe KW - Studies KW - Thromboembolism KW - Thrombosis KW - Vascular Diseases SP - 149 EP - 52 JF - Contraception JO - Contraception VL - 54 IS - 3 N2 - Resistance to activated protein C (APC-R) is at present considered the most frequent laboratory abnormality in patients with deep vein thrombosis. An increased risk for venous thrombosis is associated with the use of oral contraceptives (OCs). We recently described a statistically significant association between APC-R status and oral contraceptives use in a healthy group of women. We re-evaluated 50 healthy women taking low-dose combination OCs in order to consider a possible correlation between the APC sensitivity ratio (APC-SR) and different oral contraceptive formulations. Seven women showed an APC ratio < or = 2 (APC-resistant). Only one of the seven women was found to be heterozygous for Leiden factor V mutation. We observed no significant differences between normally sensitive and APC-resistant women in terms of duration of OC use, amount of estrogenic or progestogenic dose, or type of formulation. We conclude that APC-resistance associated with oral contraceptives use seems to occur only in predisposed subjects (in our results, about 12% of the healthy population). SN - 0010-7824 UR - https://www.unboundmedicine.com/medline/citation/8899255/Resistance_to_activated_protein_C_associated_with_oral_contraceptives_use L2 - https://linkinghub.elsevier.com/retrieve/pii/S0010782496001692 DB - PRIME DP - Unbound Medicine ER -