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Regression of Kayser-Fleischer rings during oral zinc therapy: correlation with systemic manifestations of Wilson's disease.
Cornea. 1996 Nov; 15(6):582-8.C

Abstract

Fourteen patients presenting with neuropsychiatric manifestations of Wilson's disease were treated with oral tetrathiomolybdate (TM) for 8 weeks followed by oral zinc (Zn) maintenance therapy. The patients were evaluated prospectively at baseline and at yearly intervals for up to 5 years by slit-lamp biomicroscopy and photography, quantitative neurologic and speech pathology examinations, 24-h urine copper collection, and a quantitative scoring of magnetic resonance imaging (MRI) of the brain. Kayser-Fleischer (KF) ring size decreased significantly during the 5-year study period (p < 0.0001). Although results of neurologic examination, speech pathology examination, and 24-h urine copper level analysis in symptomatic Wilson's disease patients improved during the study period, KF ring regression did not correlate with the improvement in these clinical parameters (p > 0.05). However, there was a correlation between MRI scores and KF ring regression (p = 0.02). Anticopper therapy with TM followed by zinc maintenance therapy is a safe and effective treatment for patients with neurologically symptomatic Wilson's disease. This treatment leads to reduction in KF ring size; however, KF ring reduction is not a good predictor of clinical improvement for patients with neuropsychiatric manifestations of Wilson's disease.

Authors+Show Affiliations

Department of Ophthalmology, W.K. Kellogg Eye Center, Ann Arbor, MI 48105, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

8899270

Citation

Esmaeli, B, et al. "Regression of Kayser-Fleischer Rings During Oral Zinc Therapy: Correlation With Systemic Manifestations of Wilson's Disease." Cornea, vol. 15, no. 6, 1996, pp. 582-8.
Esmaeli B, Burnstine MA, Martonyi CL, et al. Regression of Kayser-Fleischer rings during oral zinc therapy: correlation with systemic manifestations of Wilson's disease. Cornea. 1996;15(6):582-8.
Esmaeli, B., Burnstine, M. A., Martonyi, C. L., Sugar, A., Johnson, V., & Brewer, G. J. (1996). Regression of Kayser-Fleischer rings during oral zinc therapy: correlation with systemic manifestations of Wilson's disease. Cornea, 15(6), 582-8.
Esmaeli B, et al. Regression of Kayser-Fleischer Rings During Oral Zinc Therapy: Correlation With Systemic Manifestations of Wilson's Disease. Cornea. 1996;15(6):582-8. PubMed PMID: 8899270.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Regression of Kayser-Fleischer rings during oral zinc therapy: correlation with systemic manifestations of Wilson's disease. AU - Esmaeli,B, AU - Burnstine,M A, AU - Martonyi,C L, AU - Sugar,A, AU - Johnson,V, AU - Brewer,G J, PY - 1996/11/1/pubmed PY - 1996/11/1/medline PY - 1996/11/1/entrez SP - 582 EP - 8 JF - Cornea JO - Cornea VL - 15 IS - 6 N2 - Fourteen patients presenting with neuropsychiatric manifestations of Wilson's disease were treated with oral tetrathiomolybdate (TM) for 8 weeks followed by oral zinc (Zn) maintenance therapy. The patients were evaluated prospectively at baseline and at yearly intervals for up to 5 years by slit-lamp biomicroscopy and photography, quantitative neurologic and speech pathology examinations, 24-h urine copper collection, and a quantitative scoring of magnetic resonance imaging (MRI) of the brain. Kayser-Fleischer (KF) ring size decreased significantly during the 5-year study period (p < 0.0001). Although results of neurologic examination, speech pathology examination, and 24-h urine copper level analysis in symptomatic Wilson's disease patients improved during the study period, KF ring regression did not correlate with the improvement in these clinical parameters (p > 0.05). However, there was a correlation between MRI scores and KF ring regression (p = 0.02). Anticopper therapy with TM followed by zinc maintenance therapy is a safe and effective treatment for patients with neurologically symptomatic Wilson's disease. This treatment leads to reduction in KF ring size; however, KF ring reduction is not a good predictor of clinical improvement for patients with neuropsychiatric manifestations of Wilson's disease. SN - 0277-3740 UR - https://www.unboundmedicine.com/medline/citation/8899270/Regression_of_Kayser_Fleischer_rings_during_oral_zinc_therapy:_correlation_with_systemic_manifestations_of_Wilson's_disease_ L2 - https://Insights.ovid.com/pubmed?pmid=8899270 DB - PRIME DP - Unbound Medicine ER -