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Plasma cholesteryl ester synthesis, cholesteryl ester transfer protein concentration and activity in hypercholesterolemic women: effects of the degree of saturation of dietary fatty acids in the fasting and postprandial states.
Atherosclerosis. 1996 Oct 25; 126(2):265-75.A

Abstract

Hypercholesterolemic women (n = 19) sequentially maintained on a long-term saturated (SAT) or a polyunsaturated (PUFA) fatty acid-rich diet, respectively, were studied in the fasting state and after a meal rich in SAT or PUFA. When apo B-containing lipoprotein was excluded from plasma the in vitro HDL-14C-cholesterol esterification rate was identical for the saturated (SAT) and polyunsaturated (PUFA) fatty acid diets, and did not increase during the postprandial period. Rates of transfer of 14C-cholesteryl ester to apo B-containing lipoproteins from HDL were also similar for both diets in the fasting state and increased to the same extent in the postprandial period in parallel with the rise in plasma triglycerides. When transfer data were related to the plasma concentration of apo B, the gain of cholesteryl ester by the triglyceride-containing particles (VLDL + LDL) also increased in the postprandial period to a similar extent for both diets. Cholesteryl ester transfer protein (CETP) concentration measured by radioimmunoassay was similar during both experimental diets, although greater in the postprandial period for the PUFA diet. The rate limiting factor for CETP-mediated transfer of HDL-derived cholesteryl ester (CE) was the plasma triglyceride concentration, that is, the content of triglycerides per lipoprotein particle and the quantity of TG-containing particles (VLDL + LDL). In contrast, the fatty acid composition of these particles had less effect on CETP-mediated CE transfer.

Authors+Show Affiliations

Division of Nutrition and Lipids Laboratory (LIM 10), Hospital of the University of São Paulo Medical School, Brazil.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8902152

Citation

Lottenberg, A M., et al. "Plasma Cholesteryl Ester Synthesis, Cholesteryl Ester Transfer Protein Concentration and Activity in Hypercholesterolemic Women: Effects of the Degree of Saturation of Dietary Fatty Acids in the Fasting and Postprandial States." Atherosclerosis, vol. 126, no. 2, 1996, pp. 265-75.
Lottenberg AM, Nunes VS, Lottenberg SA, et al. Plasma cholesteryl ester synthesis, cholesteryl ester transfer protein concentration and activity in hypercholesterolemic women: effects of the degree of saturation of dietary fatty acids in the fasting and postprandial states. Atherosclerosis. 1996;126(2):265-75.
Lottenberg, A. M., Nunes, V. S., Lottenberg, S. A., Shimabukuro, A. F., Carrilho, A. J., Malagutti, S., Nakandakare, E. R., McPherson, R., & Quintão, E. C. (1996). Plasma cholesteryl ester synthesis, cholesteryl ester transfer protein concentration and activity in hypercholesterolemic women: effects of the degree of saturation of dietary fatty acids in the fasting and postprandial states. Atherosclerosis, 126(2), 265-75.
Lottenberg AM, et al. Plasma Cholesteryl Ester Synthesis, Cholesteryl Ester Transfer Protein Concentration and Activity in Hypercholesterolemic Women: Effects of the Degree of Saturation of Dietary Fatty Acids in the Fasting and Postprandial States. Atherosclerosis. 1996 Oct 25;126(2):265-75. PubMed PMID: 8902152.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Plasma cholesteryl ester synthesis, cholesteryl ester transfer protein concentration and activity in hypercholesterolemic women: effects of the degree of saturation of dietary fatty acids in the fasting and postprandial states. AU - Lottenberg,A M, AU - Nunes,V S, AU - Lottenberg,S A, AU - Shimabukuro,A F, AU - Carrilho,A J, AU - Malagutti,S, AU - Nakandakare,E R, AU - McPherson,R, AU - Quintão,E C, PY - 1996/10/25/pubmed PY - 1996/10/25/medline PY - 1996/10/25/entrez SP - 265 EP - 75 JF - Atherosclerosis JO - Atherosclerosis VL - 126 IS - 2 N2 - Hypercholesterolemic women (n = 19) sequentially maintained on a long-term saturated (SAT) or a polyunsaturated (PUFA) fatty acid-rich diet, respectively, were studied in the fasting state and after a meal rich in SAT or PUFA. When apo B-containing lipoprotein was excluded from plasma the in vitro HDL-14C-cholesterol esterification rate was identical for the saturated (SAT) and polyunsaturated (PUFA) fatty acid diets, and did not increase during the postprandial period. Rates of transfer of 14C-cholesteryl ester to apo B-containing lipoproteins from HDL were also similar for both diets in the fasting state and increased to the same extent in the postprandial period in parallel with the rise in plasma triglycerides. When transfer data were related to the plasma concentration of apo B, the gain of cholesteryl ester by the triglyceride-containing particles (VLDL + LDL) also increased in the postprandial period to a similar extent for both diets. Cholesteryl ester transfer protein (CETP) concentration measured by radioimmunoassay was similar during both experimental diets, although greater in the postprandial period for the PUFA diet. The rate limiting factor for CETP-mediated transfer of HDL-derived cholesteryl ester (CE) was the plasma triglyceride concentration, that is, the content of triglycerides per lipoprotein particle and the quantity of TG-containing particles (VLDL + LDL). In contrast, the fatty acid composition of these particles had less effect on CETP-mediated CE transfer. SN - 0021-9150 UR - https://www.unboundmedicine.com/medline/citation/8902152/Plasma_cholesteryl_ester_synthesis_cholesteryl_ester_transfer_protein_concentration_and_activity_in_hypercholesterolemic_women:_effects_of_the_degree_of_saturation_of_dietary_fatty_acids_in_the_fasting_and_postprandial_states_ L2 - https://linkinghub.elsevier.com/retrieve/pii/0021-9150(96)05914-X DB - PRIME DP - Unbound Medicine ER -