Tags

Type your tag names separated by a space and hit enter

Plasma factor VII and its relation to adipose tissue fatty acids and other atherogenic risk factors in healthy men.
Eur J Clin Invest. 1996 Mar; 26(3):247-53.EJ

Abstract

In this study the authors examined the relationships of plasma factor VII (F-VII) to adipose tissue fatty acid composition, as an objective index of the habitual dietary fat intake, as well as to a number of other atherogenic risk factors in 60 healthy male volunteers (aged 38 years). Significant positive correlations were found between plasma F-VII [measured as antigen (F-VIIAg) and coagulant activity, using bovine thromboplastin (F-VIIbt)] and body mass index (BMI), waist-thigh girth ratio (WTR), cigarette smoking and plasma triglyceride concentration. After adjustment for BMI, only plasma triglycerides remained positively correlated with F-VII (r = 0 center dot 27, P = 0 center dot 03, and r = 0 center dot 29, P < 0 center dot 01, for F-VIIbt and F-VIIAg respectively). A significant positive relation was found between F-VII and the total proportion of fatty acid as monounsaturated fatty acid (r = 0 center dot 26, P < 0 center dot 05, for F-VIIAg), whereas inverse relations were found between F-VII, the total proportion of fatty acid as polyunsaturated fatty acid (r = -0 center dot 26 and r = -0 center dot 25, P < 0 center dot 05, for F-VIIbt and F-VIIAg respectively), polyunsaturated-saturated fat ratio (r = -0 center dot 25, P < 0 center dot 05, for F-VIIbt) and, more significantly, between F-VII and adipose-tissue alpha-linolenic acid (r = -0 center dot 29, P < 0 center dot 01, for F-VIIbt and r = -0 center dot 49, P < 0 center dot 001, for F-VIIAg). All these correlations remained significant after matching for BMI. In a multiple linear regression analysis, only adipose tissue alpha-linolenic acid was a negative and independent predictor of F-VIIAg (P = 0 center dot 004) and, at borderline significance, of F-VIIbt (P = 0 center dot 061) when allowance was made for BMI, WTR, smoking and plasma triglycerides. In conclusion, this study shows significant relations between F-VII and adipose tissue fatty acid composition in healthy male individuals; it supports the possibility that adipose tissue poly-unsaturated fatty acids, derived from dietary intake, play a role in the relation between F-VII and coronary heart disease (CHD), thus suggesting that high dietary polyunsaturated fatty acid intake (especially alpha-linolenic acid) may reduce the risk for CHD by an improvement of a number of risk factors, including a lowering of plasma F-VII (both activity and antigen).

Authors+Show Affiliations

Institute of Clinical Medicine, University of Verona, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

8904355

Citation

Cigolini, M, et al. "Plasma Factor VII and Its Relation to Adipose Tissue Fatty Acids and Other Atherogenic Risk Factors in Healthy Men." European Journal of Clinical Investigation, vol. 26, no. 3, 1996, pp. 247-53.
Cigolini M, Targher G, Seidell JC, et al. Plasma factor VII and its relation to adipose tissue fatty acids and other atherogenic risk factors in healthy men. Eur J Clin Invest. 1996;26(3):247-53.
Cigolini, M., Targher, G., Seidell, J. C., Schiavon, R., Tonoli, M., Muggeo, M., & De Sandre, G. (1996). Plasma factor VII and its relation to adipose tissue fatty acids and other atherogenic risk factors in healthy men. European Journal of Clinical Investigation, 26(3), 247-53.
Cigolini M, et al. Plasma Factor VII and Its Relation to Adipose Tissue Fatty Acids and Other Atherogenic Risk Factors in Healthy Men. Eur J Clin Invest. 1996;26(3):247-53. PubMed PMID: 8904355.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Plasma factor VII and its relation to adipose tissue fatty acids and other atherogenic risk factors in healthy men. AU - Cigolini,M, AU - Targher,G, AU - Seidell,J C, AU - Schiavon,R, AU - Tonoli,M, AU - Muggeo,M, AU - De Sandre,G, PY - 1996/3/1/pubmed PY - 1996/3/1/medline PY - 1996/3/1/entrez SP - 247 EP - 53 JF - European journal of clinical investigation JO - Eur J Clin Invest VL - 26 IS - 3 N2 - In this study the authors examined the relationships of plasma factor VII (F-VII) to adipose tissue fatty acid composition, as an objective index of the habitual dietary fat intake, as well as to a number of other atherogenic risk factors in 60 healthy male volunteers (aged 38 years). Significant positive correlations were found between plasma F-VII [measured as antigen (F-VIIAg) and coagulant activity, using bovine thromboplastin (F-VIIbt)] and body mass index (BMI), waist-thigh girth ratio (WTR), cigarette smoking and plasma triglyceride concentration. After adjustment for BMI, only plasma triglycerides remained positively correlated with F-VII (r = 0 center dot 27, P = 0 center dot 03, and r = 0 center dot 29, P < 0 center dot 01, for F-VIIbt and F-VIIAg respectively). A significant positive relation was found between F-VII and the total proportion of fatty acid as monounsaturated fatty acid (r = 0 center dot 26, P < 0 center dot 05, for F-VIIAg), whereas inverse relations were found between F-VII, the total proportion of fatty acid as polyunsaturated fatty acid (r = -0 center dot 26 and r = -0 center dot 25, P < 0 center dot 05, for F-VIIbt and F-VIIAg respectively), polyunsaturated-saturated fat ratio (r = -0 center dot 25, P < 0 center dot 05, for F-VIIbt) and, more significantly, between F-VII and adipose-tissue alpha-linolenic acid (r = -0 center dot 29, P < 0 center dot 01, for F-VIIbt and r = -0 center dot 49, P < 0 center dot 001, for F-VIIAg). All these correlations remained significant after matching for BMI. In a multiple linear regression analysis, only adipose tissue alpha-linolenic acid was a negative and independent predictor of F-VIIAg (P = 0 center dot 004) and, at borderline significance, of F-VIIbt (P = 0 center dot 061) when allowance was made for BMI, WTR, smoking and plasma triglycerides. In conclusion, this study shows significant relations between F-VII and adipose tissue fatty acid composition in healthy male individuals; it supports the possibility that adipose tissue poly-unsaturated fatty acids, derived from dietary intake, play a role in the relation between F-VII and coronary heart disease (CHD), thus suggesting that high dietary polyunsaturated fatty acid intake (especially alpha-linolenic acid) may reduce the risk for CHD by an improvement of a number of risk factors, including a lowering of plasma F-VII (both activity and antigen). SN - 0014-2972 UR - https://www.unboundmedicine.com/medline/citation/8904355/Plasma_factor_VII_and_its_relation_to_adipose_tissue_fatty_acids_and_other_atherogenic_risk_factors_in_healthy_men_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&amp;sid=nlm:pubmed&amp;issn=0014-2972&amp;date=1996&amp;volume=26&amp;issue=3&amp;spage=247 DB - PRIME DP - Unbound Medicine ER -