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Are body mass or insulin resistance independently associated with cardiovascular risk factors in non-diabetic elderly Nigerians?
Diabet Med. 1996 Oct; 13(10):874-81.DM

Abstract

The aim was to establish whether risk factors for cardiovascular disease (CVD) are positively and independently associated with fasting insulin and/or body mass and waist-hip ratio in healthy elderly Nigerian subjects. Fasting plasma glucose, insulin, total cholesterol, triglycerides, blood pressure, and basal insulin resistance (HOMA method) were measured in 500 healthy elderly (> or = 55 years) Nigerian volunteers (295 men, 205 women). Associations between blood pressure, triglycerides or cholesterol and fasting insulin, HOMA, body mass index (BMI) or waist-hip ratio were examined using linear regression. Age was controlled for in all analyses. In men, diastolic and systolic blood pressure were strongly associated with BMI, while there was no evidence of an independent relationship with fasting insulin or HOMA. Triglycerides were strongly associated with waist-hip ratio, with a weaker independent association with HOMA but not fasting insulin; fasting insulin and HOMA showed strong independent associations with total cholesterol. In women diastolic and systolic blood pressure were also strongly associated with BMI, but there was an independent relationship with fasting insulin for diastolic blood pressure and a less significant (p = 0.057) one for systolic blood pressure. Triglycerides were significantly associated with BMI but none of the other variables; there were no significant associations with cholesterol. There was no evidence of interaction between fasting insulin or HOMA and BMI or waist-hip ratio. The results suggest the hypotheses that in this population BMI or waist-hip ratio are stronger determinants of blood pressure and triglyceride levels than fasting insulin or HOMA, and that where insulin does play a role its effects are separate and additive.

Authors+Show Affiliations

Department of Chemical Pathology, University College Hospital, Ibadan, Nigeria.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8911781

Citation

Ezenwaka, C E., et al. "Are Body Mass or Insulin Resistance Independently Associated With Cardiovascular Risk Factors in Non-diabetic Elderly Nigerians?" Diabetic Medicine : a Journal of the British Diabetic Association, vol. 13, no. 10, 1996, pp. 874-81.
Ezenwaka CE, Akanji AO, Unwin N, et al. Are body mass or insulin resistance independently associated with cardiovascular risk factors in non-diabetic elderly Nigerians? Diabet Med. 1996;13(10):874-81.
Ezenwaka, C. E., Akanji, A. O., Unwin, N., & Alberti, K. G. (1996). Are body mass or insulin resistance independently associated with cardiovascular risk factors in non-diabetic elderly Nigerians? Diabetic Medicine : a Journal of the British Diabetic Association, 13(10), 874-81.
Ezenwaka CE, et al. Are Body Mass or Insulin Resistance Independently Associated With Cardiovascular Risk Factors in Non-diabetic Elderly Nigerians. Diabet Med. 1996;13(10):874-81. PubMed PMID: 8911781.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Are body mass or insulin resistance independently associated with cardiovascular risk factors in non-diabetic elderly Nigerians? AU - Ezenwaka,C E, AU - Akanji,A O, AU - Unwin,N, AU - Alberti,K G, PY - 1996/10/1/pubmed PY - 1996/10/1/medline PY - 1996/10/1/entrez SP - 874 EP - 81 JF - Diabetic medicine : a journal of the British Diabetic Association JO - Diabet Med VL - 13 IS - 10 N2 - The aim was to establish whether risk factors for cardiovascular disease (CVD) are positively and independently associated with fasting insulin and/or body mass and waist-hip ratio in healthy elderly Nigerian subjects. Fasting plasma glucose, insulin, total cholesterol, triglycerides, blood pressure, and basal insulin resistance (HOMA method) were measured in 500 healthy elderly (> or = 55 years) Nigerian volunteers (295 men, 205 women). Associations between blood pressure, triglycerides or cholesterol and fasting insulin, HOMA, body mass index (BMI) or waist-hip ratio were examined using linear regression. Age was controlled for in all analyses. In men, diastolic and systolic blood pressure were strongly associated with BMI, while there was no evidence of an independent relationship with fasting insulin or HOMA. Triglycerides were strongly associated with waist-hip ratio, with a weaker independent association with HOMA but not fasting insulin; fasting insulin and HOMA showed strong independent associations with total cholesterol. In women diastolic and systolic blood pressure were also strongly associated with BMI, but there was an independent relationship with fasting insulin for diastolic blood pressure and a less significant (p = 0.057) one for systolic blood pressure. Triglycerides were significantly associated with BMI but none of the other variables; there were no significant associations with cholesterol. There was no evidence of interaction between fasting insulin or HOMA and BMI or waist-hip ratio. The results suggest the hypotheses that in this population BMI or waist-hip ratio are stronger determinants of blood pressure and triglyceride levels than fasting insulin or HOMA, and that where insulin does play a role its effects are separate and additive. SN - 0742-3071 UR - https://www.unboundmedicine.com/medline/citation/8911781/Are_body_mass_or_insulin_resistance_independently_associated_with_cardiovascular_risk_factors_in_non_diabetic_elderly_Nigerians DB - PRIME DP - Unbound Medicine ER -