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Relationship between sustained elevation of serum alanine aminotransferase and progression from cirrhosis to hepatocellular carcinoma: comparison in patients with hepatitis B virus- and hepatitis C virus-associated cirrhosis.
J Gastroenterol Hepatol 1996; 11(10):944-8JG

Abstract

Most patients with hepatocellular carcinoma (HCC) in Japan have hepatitis B virus (HBV)-or hepatitis C virus (HCV)-associated cirrhosis. In the present study, the risk of HCC in patients with cirrhosis was analysed by the levels of serum alanine aminotransferase (ALT). One hundred and one (78%) of 129 patients with cirrhosis registered from April 1979 were followed at monthly intervals with the measurement of serum ALT. Of 101 patients, 38 tested positive for hepatitis B surface antigen (HBsAg) but negative for antibody to HCV (anti-HCV; HBV group), 47 tested negative for HBsAg but positive for anti-HCV (HCV group) and nine tested positive and seven tested negative for both. Mean serum ALT during follow-up was calculated on the basis of monthly values during the observation period that started at enrolment and ended with the detection of HCC or at the end of March 1994. By the end of March 1994, 37 (37%) patients developed HCC; 12 were in the HBV group, 21 in the HCV group and four were in the group positive for both. Mean serum ALT during the observation period was similar in patients who developed HCC and those who did not develop HCC in the HBV group. In contrast, the value was significantly higher in patients who developed HCC than in patients who did not develop HCC in the HCV group (P < 0.05).

Authors+Show Affiliations

First Department of Internal Medicine, Nagasaki University School of Medicine, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

8912132

Citation

Sato, A, et al. "Relationship Between Sustained Elevation of Serum Alanine Aminotransferase and Progression From Cirrhosis to Hepatocellular Carcinoma: Comparison in Patients With Hepatitis B Virus- and Hepatitis C Virus-associated Cirrhosis." Journal of Gastroenterology and Hepatology, vol. 11, no. 10, 1996, pp. 944-8.
Sato A, Kato Y, Nakata K, et al. Relationship between sustained elevation of serum alanine aminotransferase and progression from cirrhosis to hepatocellular carcinoma: comparison in patients with hepatitis B virus- and hepatitis C virus-associated cirrhosis. J Gastroenterol Hepatol. 1996;11(10):944-8.
Sato, A., Kato, Y., Nakata, K., Nakao, K., Daikoku, M., Ishii, N., ... Nagataki, S. (1996). Relationship between sustained elevation of serum alanine aminotransferase and progression from cirrhosis to hepatocellular carcinoma: comparison in patients with hepatitis B virus- and hepatitis C virus-associated cirrhosis. Journal of Gastroenterology and Hepatology, 11(10), pp. 944-8.
Sato A, et al. Relationship Between Sustained Elevation of Serum Alanine Aminotransferase and Progression From Cirrhosis to Hepatocellular Carcinoma: Comparison in Patients With Hepatitis B Virus- and Hepatitis C Virus-associated Cirrhosis. J Gastroenterol Hepatol. 1996;11(10):944-8. PubMed PMID: 8912132.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Relationship between sustained elevation of serum alanine aminotransferase and progression from cirrhosis to hepatocellular carcinoma: comparison in patients with hepatitis B virus- and hepatitis C virus-associated cirrhosis. AU - Sato,A, AU - Kato,Y, AU - Nakata,K, AU - Nakao,K, AU - Daikoku,M, AU - Ishii,N, AU - Matsumoto,T, AU - Iseki,K, AU - Mazume,H, AU - Nagataki,S, PY - 1996/10/1/pubmed PY - 1996/10/1/medline PY - 1996/10/1/entrez SP - 944 EP - 8 JF - Journal of gastroenterology and hepatology JO - J. Gastroenterol. Hepatol. VL - 11 IS - 10 N2 - Most patients with hepatocellular carcinoma (HCC) in Japan have hepatitis B virus (HBV)-or hepatitis C virus (HCV)-associated cirrhosis. In the present study, the risk of HCC in patients with cirrhosis was analysed by the levels of serum alanine aminotransferase (ALT). One hundred and one (78%) of 129 patients with cirrhosis registered from April 1979 were followed at monthly intervals with the measurement of serum ALT. Of 101 patients, 38 tested positive for hepatitis B surface antigen (HBsAg) but negative for antibody to HCV (anti-HCV; HBV group), 47 tested negative for HBsAg but positive for anti-HCV (HCV group) and nine tested positive and seven tested negative for both. Mean serum ALT during follow-up was calculated on the basis of monthly values during the observation period that started at enrolment and ended with the detection of HCC or at the end of March 1994. By the end of March 1994, 37 (37%) patients developed HCC; 12 were in the HBV group, 21 in the HCV group and four were in the group positive for both. Mean serum ALT during the observation period was similar in patients who developed HCC and those who did not develop HCC in the HBV group. In contrast, the value was significantly higher in patients who developed HCC than in patients who did not develop HCC in the HCV group (P < 0.05). SN - 0815-9319 UR - https://www.unboundmedicine.com/medline/citation/8912132/Relationship_between_sustained_elevation_of_serum_alanine_aminotransferase_and_progression_from_cirrhosis_to_hepatocellular_carcinoma:_comparison_in_patients_with_hepatitis_B_virus__and_hepatitis_C_virus_associated_cirrhosis_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&amp;sid=nlm:pubmed&amp;issn=0815-9319&amp;date=1996&amp;volume=11&amp;issue=10&amp;spage=944 DB - PRIME DP - Unbound Medicine ER -