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A randomized, double-blind crossover trial of fluoxetine and amitriptyline in the treatment of fibromyalgia.
Arthritis Rheum 1996; 39(11):1852-9AR

Abstract

OBJECTIVE

To study the effect of fluoxetine (FL) and amitriptyline (AM), alone and in combination, in patients with fibromyalgia (FM).

METHODS

Nineteen patients with FM completed a randomized, double-blind crossover study, which consisted of 4 6-week trials of FL (20 mg), AM (25 mg), a combination of FL and AM, or placebo. Patients were evaluated on the first and last day of each trial period. Outcome measures included a tender point score, the Fibromyalgia Impact Questionnaire (FIQ), the Beck Depression Inventory (BDI) scale, and visual analog scales (VAS) for global well-being (1 completed by the physician and 1 by the patient), pain, sleep trouble, fatigue, and feeling refreshed upon awakening.

RESULTS

Both FL and AM were associated with significantly improved scores on the FIQ and on the VAS for pain, global well-being, and sleep disturbances. When combined, the 2 treatments worked better than either medication alone. Similar, but nonsignificant, improvement occurred in the BDI scale, the physician global VAS, and the VAS for fatigue and feeling refreshed upon awakening. Trends were less clear for the tender point score.

CONCLUSION

Both FL and AM are effective treatments for FM, and they work better in combination than either medication alone.

Authors+Show Affiliations

Newton-Wellesley Hospital, Massachusette, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8912507

Citation

Goldenberg, D, et al. "A Randomized, Double-blind Crossover Trial of Fluoxetine and Amitriptyline in the Treatment of Fibromyalgia." Arthritis and Rheumatism, vol. 39, no. 11, 1996, pp. 1852-9.
Goldenberg D, Mayskiy M, Mossey C, et al. A randomized, double-blind crossover trial of fluoxetine and amitriptyline in the treatment of fibromyalgia. Arthritis Rheum. 1996;39(11):1852-9.
Goldenberg, D., Mayskiy, M., Mossey, C., Ruthazer, R., & Schmid, C. (1996). A randomized, double-blind crossover trial of fluoxetine and amitriptyline in the treatment of fibromyalgia. Arthritis and Rheumatism, 39(11), pp. 1852-9.
Goldenberg D, et al. A Randomized, Double-blind Crossover Trial of Fluoxetine and Amitriptyline in the Treatment of Fibromyalgia. Arthritis Rheum. 1996;39(11):1852-9. PubMed PMID: 8912507.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A randomized, double-blind crossover trial of fluoxetine and amitriptyline in the treatment of fibromyalgia. AU - Goldenberg,D, AU - Mayskiy,M, AU - Mossey,C, AU - Ruthazer,R, AU - Schmid,C, PY - 1996/11/1/pubmed PY - 1996/11/1/medline PY - 1996/11/1/entrez SP - 1852 EP - 9 JF - Arthritis and rheumatism JO - Arthritis Rheum. VL - 39 IS - 11 N2 - OBJECTIVE: To study the effect of fluoxetine (FL) and amitriptyline (AM), alone and in combination, in patients with fibromyalgia (FM). METHODS: Nineteen patients with FM completed a randomized, double-blind crossover study, which consisted of 4 6-week trials of FL (20 mg), AM (25 mg), a combination of FL and AM, or placebo. Patients were evaluated on the first and last day of each trial period. Outcome measures included a tender point score, the Fibromyalgia Impact Questionnaire (FIQ), the Beck Depression Inventory (BDI) scale, and visual analog scales (VAS) for global well-being (1 completed by the physician and 1 by the patient), pain, sleep trouble, fatigue, and feeling refreshed upon awakening. RESULTS: Both FL and AM were associated with significantly improved scores on the FIQ and on the VAS for pain, global well-being, and sleep disturbances. When combined, the 2 treatments worked better than either medication alone. Similar, but nonsignificant, improvement occurred in the BDI scale, the physician global VAS, and the VAS for fatigue and feeling refreshed upon awakening. Trends were less clear for the tender point score. CONCLUSION: Both FL and AM are effective treatments for FM, and they work better in combination than either medication alone. SN - 0004-3591 UR - https://www.unboundmedicine.com/medline/citation/8912507/full_citation L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0004-3591&date=1996&volume=39&issue=11&spage=1852 DB - PRIME DP - Unbound Medicine ER -