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Juvenile chronic arthritis and coeliac disease in The Netherlands.
Clin Exp Rheumatol 1996 Sep-Oct; 14(5):571-5CE

Abstract

OBJECTIVE

It has been suggested that juvenile chronic arthritis (JCA) is associated with coeliac disease in a frequency of 0.4-2%. In order to investigate the frequency of coeliac disease in cases of JCA and the possibility of underdiagnosis in our area, we screened 62 children with JCA (mean age 9.8 +/- 3.5 year) for coeliac disease.

METHODS

All children were screened for coeliac disease by measuring the IgA-class of antigliadin, antireticulin and antiendomysium antibodies in serum and by measuring intestinal permeability by a sugar absorption test using lactulose and mannitol. In cases of at least one positive test, a small-bowel biopsy for diagnosis of coeliac disease was offered.

RESULTS

Of the 62 children with JCA, 8 had an abnormal screening result and were suspected of having coeliac disease. In four of the five children in whom a small-bowel biopsy was performed, the intestinal mucosa was normal and in one child villous atrophy characteristic of coeliac disease was found. Therefore, the prevalence of coeliac disease in our study group was 1.5%, which is in agreement with the literature.

CONCLUSION

These findings indicate no underdiagnosis of coeliac disease in JCA in our area.

Authors+Show Affiliations

Department of Paediatrics, University Hospital Leiden, The Netherlands.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8913663

Citation

George, E K., et al. "Juvenile Chronic Arthritis and Coeliac Disease in the Netherlands." Clinical and Experimental Rheumatology, vol. 14, no. 5, 1996, pp. 571-5.
George EK, Hertzberger-ten Cate R, van Suijlekom-Smit LW, et al. Juvenile chronic arthritis and coeliac disease in The Netherlands. Clin Exp Rheumatol. 1996;14(5):571-5.
George, E. K., Hertzberger-ten Cate, R., van Suijlekom-Smit, L. W., von Blomberg, B. M., Stapel, S. O., van Elburg, R. M., & Mearin, M. L. (1996). Juvenile chronic arthritis and coeliac disease in The Netherlands. Clinical and Experimental Rheumatology, 14(5), pp. 571-5.
George EK, et al. Juvenile Chronic Arthritis and Coeliac Disease in the Netherlands. Clin Exp Rheumatol. 1996;14(5):571-5. PubMed PMID: 8913663.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Juvenile chronic arthritis and coeliac disease in The Netherlands. AU - George,E K, AU - Hertzberger-ten Cate,R, AU - van Suijlekom-Smit,L W, AU - von Blomberg,B M, AU - Stapel,S O, AU - van Elburg,R M, AU - Mearin,M L, PY - 1996/9/1/pubmed PY - 1996/9/1/medline PY - 1996/9/1/entrez SP - 571 EP - 5 JF - Clinical and experimental rheumatology JO - Clin. Exp. Rheumatol. VL - 14 IS - 5 N2 - OBJECTIVE: It has been suggested that juvenile chronic arthritis (JCA) is associated with coeliac disease in a frequency of 0.4-2%. In order to investigate the frequency of coeliac disease in cases of JCA and the possibility of underdiagnosis in our area, we screened 62 children with JCA (mean age 9.8 +/- 3.5 year) for coeliac disease. METHODS: All children were screened for coeliac disease by measuring the IgA-class of antigliadin, antireticulin and antiendomysium antibodies in serum and by measuring intestinal permeability by a sugar absorption test using lactulose and mannitol. In cases of at least one positive test, a small-bowel biopsy for diagnosis of coeliac disease was offered. RESULTS: Of the 62 children with JCA, 8 had an abnormal screening result and were suspected of having coeliac disease. In four of the five children in whom a small-bowel biopsy was performed, the intestinal mucosa was normal and in one child villous atrophy characteristic of coeliac disease was found. Therefore, the prevalence of coeliac disease in our study group was 1.5%, which is in agreement with the literature. CONCLUSION: These findings indicate no underdiagnosis of coeliac disease in JCA in our area. SN - 0392-856X UR - https://www.unboundmedicine.com/medline/citation/8913663/Juvenile_chronic_arthritis_and_coeliac_disease_in_The_Netherlands_ L2 - http://www.diseaseinfosearch.org/result/592 DB - PRIME DP - Unbound Medicine ER -