Tags

Type your tag names separated by a space and hit enter

Amyloid beta-peptide and the dementia of Parkinson's disease.
Mov Disord. 1996 Nov; 11(6):647-53.MD

Abstract

It is not known whether an increased incidence of dementia in patients with Parkinson's disease (PD) is due to a higher incidence of Alzheimer's disease (AD) or to "early" Alzheimer-type pathology. To determine whether amyloid beta-peptide (A beta) of AD occurs more frequently in brains of patients with PD, we examined 50 cases and 79 controls by using histoblots for A beta. Twenty-three cases with PD had dementia, including all nine with A beta distributed throughout the entire cerebral cortex; three of these cases had AD. In contrast, five of 17 controls with comparable A beta accumulation were not demented. Neither AD nor A beta deposition was increased in PD, furthermore, there was no statistical correlation between the amount of A beta and the number of Lewy bodies in cerebral cortex. In 14 patients with PD in whom dementia was unrelated to A beta, there was cerebral vascular disease (four), numerous cortical Lewy bodies (three), or hydrocephalus (two); in five further cases, dementia was not well explained by histopathologic changes. Our data found no increase of either AD or "early" Alzheimer-type pathology in cases of PD; however, a synergistic effect between the two pathologies was suggested as contributing to dementia.

Authors+Show Affiliations

Department of Neurology, Charité, Berlin, Germany.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8914090

Citation

Jendroska, K, et al. "Amyloid Beta-peptide and the Dementia of Parkinson's Disease." Movement Disorders : Official Journal of the Movement Disorder Society, vol. 11, no. 6, 1996, pp. 647-53.
Jendroska K, Lees AJ, Poewe W, et al. Amyloid beta-peptide and the dementia of Parkinson's disease. Mov Disord. 1996;11(6):647-53.
Jendroska, K., Lees, A. J., Poewe, W., & Daniel, S. E. (1996). Amyloid beta-peptide and the dementia of Parkinson's disease. Movement Disorders : Official Journal of the Movement Disorder Society, 11(6), 647-53.
Jendroska K, et al. Amyloid Beta-peptide and the Dementia of Parkinson's Disease. Mov Disord. 1996;11(6):647-53. PubMed PMID: 8914090.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Amyloid beta-peptide and the dementia of Parkinson's disease. AU - Jendroska,K, AU - Lees,A J, AU - Poewe,W, AU - Daniel,S E, PY - 1996/11/1/pubmed PY - 1996/11/1/medline PY - 1996/11/1/entrez SP - 647 EP - 53 JF - Movement disorders : official journal of the Movement Disorder Society JO - Mov Disord VL - 11 IS - 6 N2 - It is not known whether an increased incidence of dementia in patients with Parkinson's disease (PD) is due to a higher incidence of Alzheimer's disease (AD) or to "early" Alzheimer-type pathology. To determine whether amyloid beta-peptide (A beta) of AD occurs more frequently in brains of patients with PD, we examined 50 cases and 79 controls by using histoblots for A beta. Twenty-three cases with PD had dementia, including all nine with A beta distributed throughout the entire cerebral cortex; three of these cases had AD. In contrast, five of 17 controls with comparable A beta accumulation were not demented. Neither AD nor A beta deposition was increased in PD, furthermore, there was no statistical correlation between the amount of A beta and the number of Lewy bodies in cerebral cortex. In 14 patients with PD in whom dementia was unrelated to A beta, there was cerebral vascular disease (four), numerous cortical Lewy bodies (three), or hydrocephalus (two); in five further cases, dementia was not well explained by histopathologic changes. Our data found no increase of either AD or "early" Alzheimer-type pathology in cases of PD; however, a synergistic effect between the two pathologies was suggested as contributing to dementia. SN - 0885-3185 UR - https://www.unboundmedicine.com/medline/citation/8914090/Amyloid_beta_peptide_and_the_dementia_of_Parkinson's_disease_ L2 - https://doi.org/10.1002/mds.870110609 DB - PRIME DP - Unbound Medicine ER -