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Dioxins and dioxin-like chemicals in blood and semen of American Vietnam veterans from the state of Michigan.
Am J Ind Med. 1996 Dec; 30(6):647-54.AJ

Abstract

This exposure assessment pilot study tested the hypothesis that elevated blood levels of the dioxin congener 2,3,7,8-TCDD ("TCDD"), due to Agent Orange exposure, in American Vietnam veterans could be demonstrated two to three decades after Vietnam service. A second objective was to determine if dioxins, including TCDD, are present in the semen of adult males. In the early 1990s, blood samples from 50 Vietnam veterans and three pooled semen samples from 17 of them were analyzed by high-resolution gas chromatography-mass spectroscopy for dioxins, dibenzofurans, and the dioxin-like PCBs. Fifty volunteers from the Michigan Vietnam veteran bonus list, which documented Vietnam service, were invited to participate based on their self-reported exposure to Agent Orange in Vietnam. Screening of military and medical records was performed by an epidemiologist and a physician to assure that Agent Orange exposure was possible based on job description, location of service in Vietnam, and military Agent Orange spray records. Elevated 2,3,7,8-TCDD levels, over 20 ppt on a lipid basis, could still be detected in six of the 50 veterans in this nonrandomly selected group. The dioxin and dibenzofuran congeners commonly found in the U.S. population, including TCDD, were also detected in the three pooled semen samples. Quantification and comparison on a lipid basis were not possible due to low lipid concentrations where levels were below the detection limit. Therefore, semen samples were measured and reported on a wet-weight basis. Elevated blood TCDD levels, probably related to Agent Orange exposure, can be detected between two and three decades after potential exposure in some American veterans. Original levels were estimated to be 35-1,500-fold greater that that of the general population (4 ppt, lipid) at the time of exposure. In addition, the detection of dioxins in semen suggests a possible mechanism for male-mediated adverse reproductive outcomes following Agent Orange or other dioxin exposure.

Authors+Show Affiliations

Department of Preventive Medicine, State University of New York, Binghamton 13903, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8914711

Citation

Schecter, A, et al. "Dioxins and Dioxin-like Chemicals in Blood and Semen of American Vietnam Veterans From the State of Michigan." American Journal of Industrial Medicine, vol. 30, no. 6, 1996, pp. 647-54.
Schecter A, McGee H, Stanley JS, et al. Dioxins and dioxin-like chemicals in blood and semen of American Vietnam veterans from the state of Michigan. Am J Ind Med. 1996;30(6):647-54.
Schecter, A., McGee, H., Stanley, J. S., Boggess, K., & Brandt-Rauf, P. (1996). Dioxins and dioxin-like chemicals in blood and semen of American Vietnam veterans from the state of Michigan. American Journal of Industrial Medicine, 30(6), 647-54.
Schecter A, et al. Dioxins and Dioxin-like Chemicals in Blood and Semen of American Vietnam Veterans From the State of Michigan. Am J Ind Med. 1996;30(6):647-54. PubMed PMID: 8914711.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dioxins and dioxin-like chemicals in blood and semen of American Vietnam veterans from the state of Michigan. AU - Schecter,A, AU - McGee,H, AU - Stanley,J S, AU - Boggess,K, AU - Brandt-Rauf,P, PY - 1996/12/1/pubmed PY - 2000/6/20/medline PY - 1996/12/1/entrez SP - 647 EP - 54 JF - American journal of industrial medicine JO - Am. J. Ind. Med. VL - 30 IS - 6 N2 - This exposure assessment pilot study tested the hypothesis that elevated blood levels of the dioxin congener 2,3,7,8-TCDD ("TCDD"), due to Agent Orange exposure, in American Vietnam veterans could be demonstrated two to three decades after Vietnam service. A second objective was to determine if dioxins, including TCDD, are present in the semen of adult males. In the early 1990s, blood samples from 50 Vietnam veterans and three pooled semen samples from 17 of them were analyzed by high-resolution gas chromatography-mass spectroscopy for dioxins, dibenzofurans, and the dioxin-like PCBs. Fifty volunteers from the Michigan Vietnam veteran bonus list, which documented Vietnam service, were invited to participate based on their self-reported exposure to Agent Orange in Vietnam. Screening of military and medical records was performed by an epidemiologist and a physician to assure that Agent Orange exposure was possible based on job description, location of service in Vietnam, and military Agent Orange spray records. Elevated 2,3,7,8-TCDD levels, over 20 ppt on a lipid basis, could still be detected in six of the 50 veterans in this nonrandomly selected group. The dioxin and dibenzofuran congeners commonly found in the U.S. population, including TCDD, were also detected in the three pooled semen samples. Quantification and comparison on a lipid basis were not possible due to low lipid concentrations where levels were below the detection limit. Therefore, semen samples were measured and reported on a wet-weight basis. Elevated blood TCDD levels, probably related to Agent Orange exposure, can be detected between two and three decades after potential exposure in some American veterans. Original levels were estimated to be 35-1,500-fold greater that that of the general population (4 ppt, lipid) at the time of exposure. In addition, the detection of dioxins in semen suggests a possible mechanism for male-mediated adverse reproductive outcomes following Agent Orange or other dioxin exposure. SN - 0271-3586 UR - https://www.unboundmedicine.com/medline/citation/8914711/Dioxins_and_dioxin_like_chemicals_in_blood_and_semen_of_American_Vietnam_veterans_from_the_state_of_Michigan_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0271-3586&date=1996&volume=30&issue=6&spage=647 DB - PRIME DP - Unbound Medicine ER -