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Alopecia areata in children: treatment with diphencyprone.
Br J Dermatol. 1996 Oct; 135(4):581-5.BJ

Abstract

We assessed the efficacy of diphencyprone (DPCP) treatment in a total of 26 children with alopecia areata (AA). Sixteen children had alopecia areata totalis (AAT) and 10 had alopecia areata localis (AAL). DPCP is an absolute contact sensitizer. Twenty-five children could be sensitized with a 2% DPCP solution, whereas one child could not be sensitized. Patients were treated, once a week for at least 3 months, for up to 1 year. Twenty-one of the 25 (84%) children showed hair regrowth to a greater or lesser extent after DPCP treatment. Eight of the 25 (32%) children showed cosmetically acceptable hair regrowth. Cosmetically acceptable regrowth at the end of the study was seen in four of the 15 (27%) children with AAT and in four of the 10 (40%) children with AAL. These results are comparable with those reported in an earlier study in children with AA. Our opinion is that DPCP is a beneficial therapeutic agent in children with severe AAT and AAL showing no spontaneous remission.

Authors+Show Affiliations

Clinic for Hair and Nail Diseases, Rotterdam, The Netherlands.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Controlled Clinical Trial
Journal Article

Language

eng

PubMed ID

8915150

Citation

Schuttelaar, M L., et al. "Alopecia Areata in Children: Treatment With Diphencyprone." The British Journal of Dermatology, vol. 135, no. 4, 1996, pp. 581-5.
Schuttelaar ML, Hamstra JJ, Plinck EP, et al. Alopecia areata in children: treatment with diphencyprone. Br J Dermatol. 1996;135(4):581-5.
Schuttelaar, M. L., Hamstra, J. J., Plinck, E. P., Peereboom-Wynia, J. D., Vuzevski, V. D., Mulder, P. G., & Oranje, A. P. (1996). Alopecia areata in children: treatment with diphencyprone. The British Journal of Dermatology, 135(4), 581-5.
Schuttelaar ML, et al. Alopecia Areata in Children: Treatment With Diphencyprone. Br J Dermatol. 1996;135(4):581-5. PubMed PMID: 8915150.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Alopecia areata in children: treatment with diphencyprone. AU - Schuttelaar,M L, AU - Hamstra,J J, AU - Plinck,E P, AU - Peereboom-Wynia,J D, AU - Vuzevski,V D, AU - Mulder,P G, AU - Oranje,A P, PY - 1996/10/1/pubmed PY - 1996/10/1/medline PY - 1996/10/1/entrez SP - 581 EP - 5 JF - The British journal of dermatology JO - Br J Dermatol VL - 135 IS - 4 N2 - We assessed the efficacy of diphencyprone (DPCP) treatment in a total of 26 children with alopecia areata (AA). Sixteen children had alopecia areata totalis (AAT) and 10 had alopecia areata localis (AAL). DPCP is an absolute contact sensitizer. Twenty-five children could be sensitized with a 2% DPCP solution, whereas one child could not be sensitized. Patients were treated, once a week for at least 3 months, for up to 1 year. Twenty-one of the 25 (84%) children showed hair regrowth to a greater or lesser extent after DPCP treatment. Eight of the 25 (32%) children showed cosmetically acceptable hair regrowth. Cosmetically acceptable regrowth at the end of the study was seen in four of the 15 (27%) children with AAT and in four of the 10 (40%) children with AAL. These results are comparable with those reported in an earlier study in children with AA. Our opinion is that DPCP is a beneficial therapeutic agent in children with severe AAT and AAL showing no spontaneous remission. SN - 0007-0963 UR - https://www.unboundmedicine.com/medline/citation/8915150/Alopecia_areata_in_children:_treatment_with_diphencyprone_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0007-0963&date=1996&volume=135&issue=4&spage=581 DB - PRIME DP - Unbound Medicine ER -