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Adhesion molecules (E-selectin and ICAM-1) in pulmonary allograft rejection.
Chest. 1996 Nov; 110(5):1143-9.Chest

Abstract

Vascular endothelial cells act as antigen-presenting cells in the lung allograft and stimulate alloreactive host lymphocytes. Activated lymphocytes and cytokines can induce expression of leukocyte-endothelial adhesion molecules that facilitate invasion of the allograft by circulating leukocytes. To define the role of endothelial HLA class II antigen and adhesion molecule expression in lung allograft rejection, we prospectively analyzed endothelial expression of HLA class II, E-selectin, and intercellular adhesion molecule-1 (ICAM-1) antigens in 52 transbronchial biopsy specimens from 24 lung allograft recipients as compared to normal control subjects. Thirty-one of 52 specimens showed histologic rejection and 8 of 24 patients developed histologic obliterative bronchiolitis (OB) by the end of the study period. Increased expression of HLA class II antigen was seen in 32 of 52 (62%) lung allograft specimens, but increased expression did not correlate with acute rejection or OB. In contrast, E-selectin expression was seen in 30 of 52 (58%) biopsy specimens and was associated with acute rejection (p < 0.005) and with the development of OB (p < 0.05). Increased expression of ICAM-1 was seen in only 18 of 52 (35%) biopsy specimens and did not correlate with acute rejection or OB. These data suggest that E-selectin expression may be a tissue marker of acute and chronic lung rejection possibly by promoting leukocyte adhesion to the allograft endothelium. The high levels of endothelial HLA class II expression may reflect long-term antigenic stimulation of the allograft even in the absence of rejection.

Authors+Show Affiliations

Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

8915211

Citation

Shreeniwas, R, et al. "Adhesion Molecules (E-selectin and ICAM-1) in Pulmonary Allograft Rejection." Chest, vol. 110, no. 5, 1996, pp. 1143-9.
Shreeniwas R, Schulman LL, Narasimhan M, et al. Adhesion molecules (E-selectin and ICAM-1) in pulmonary allograft rejection. Chest. 1996;110(5):1143-9.
Shreeniwas, R., Schulman, L. L., Narasimhan, M., McGregor, C. C., & Marboe, C. C. (1996). Adhesion molecules (E-selectin and ICAM-1) in pulmonary allograft rejection. Chest, 110(5), 1143-9.
Shreeniwas R, et al. Adhesion Molecules (E-selectin and ICAM-1) in Pulmonary Allograft Rejection. Chest. 1996;110(5):1143-9. PubMed PMID: 8915211.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Adhesion molecules (E-selectin and ICAM-1) in pulmonary allograft rejection. AU - Shreeniwas,R, AU - Schulman,L L, AU - Narasimhan,M, AU - McGregor,C C, AU - Marboe,C C, PY - 1996/11/1/pubmed PY - 1996/11/1/medline PY - 1996/11/1/entrez SP - 1143 EP - 9 JF - Chest JO - Chest VL - 110 IS - 5 N2 - Vascular endothelial cells act as antigen-presenting cells in the lung allograft and stimulate alloreactive host lymphocytes. Activated lymphocytes and cytokines can induce expression of leukocyte-endothelial adhesion molecules that facilitate invasion of the allograft by circulating leukocytes. To define the role of endothelial HLA class II antigen and adhesion molecule expression in lung allograft rejection, we prospectively analyzed endothelial expression of HLA class II, E-selectin, and intercellular adhesion molecule-1 (ICAM-1) antigens in 52 transbronchial biopsy specimens from 24 lung allograft recipients as compared to normal control subjects. Thirty-one of 52 specimens showed histologic rejection and 8 of 24 patients developed histologic obliterative bronchiolitis (OB) by the end of the study period. Increased expression of HLA class II antigen was seen in 32 of 52 (62%) lung allograft specimens, but increased expression did not correlate with acute rejection or OB. In contrast, E-selectin expression was seen in 30 of 52 (58%) biopsy specimens and was associated with acute rejection (p < 0.005) and with the development of OB (p < 0.05). Increased expression of ICAM-1 was seen in only 18 of 52 (35%) biopsy specimens and did not correlate with acute rejection or OB. These data suggest that E-selectin expression may be a tissue marker of acute and chronic lung rejection possibly by promoting leukocyte adhesion to the allograft endothelium. The high levels of endothelial HLA class II expression may reflect long-term antigenic stimulation of the allograft even in the absence of rejection. SN - 0012-3692 UR - https://www.unboundmedicine.com/medline/citation/8915211/Adhesion_molecules__E_selectin_and_ICAM_1__in_pulmonary_allograft_rejection_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0012-3692(15)46514-6 DB - PRIME DP - Unbound Medicine ER -