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Intrauterine growth pattern and risk of childhood onset insulin dependent (type I) diabetes: population based case-control study.
BMJ 1996; 313(7066):1174-7BMJ

Abstract

OBJECTIVE

To investigate whether prenatal growth affects the risk of development of childhood onset insulin dependent (type I) diabetes mellitus.

DESIGN

Population based case-control study.

SETTING

Data from a nationwide childhood diabetes case register were linked with data from the nationwide Swedish Medical Birth Registry.

SUBJECTS

Data from a total of 4584 diabetic children born after 1973 and diagnosed with diabetes from 1978 to 1992 were studied. For each child with insulin dependent diabetes three control children were randomly selected from among all infants born in the same year and at the same hospital as the proband.

MAIN OUTCOME MEASURES

Birth weight, gestation, maternal age and parity, number of previous spontaneous abortions, and sex specific birth weight by gestational week expressed as multiples of the standard deviation (SD).

RESULTS

There was a clear trend in the odds ratio for childhood onset diabetes according to SD of birth weight. The odds ratio (95% confidence interval) for small for gestational age after stratification for maternal age, parity, smoking habits, and maternal diabetes was 0.81 (0.65 to 0.99) and for large for gestational age after similar stratification was 1.20 (1.02 to 1.42).

CONCLUSIONS

Intrauterine conditions that affect prenatal growth seem also to affect the risk of development of childhood diabetes in the way previously described for postnatal growth: a poor growth decreases and an excess growth increases the risk. The mechanism for this association is unclear.

Authors+Show Affiliations

Department of Paediatrics, University of Umeå, Sweden.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8916747

Citation

Dahlquist, G, et al. "Intrauterine Growth Pattern and Risk of Childhood Onset Insulin Dependent (type I) Diabetes: Population Based Case-control Study." BMJ (Clinical Research Ed.), vol. 313, no. 7066, 1996, pp. 1174-7.
Dahlquist G, Bennich SS, Källén B. Intrauterine growth pattern and risk of childhood onset insulin dependent (type I) diabetes: population based case-control study. BMJ. 1996;313(7066):1174-7.
Dahlquist, G., Bennich, S. S., & Källén, B. (1996). Intrauterine growth pattern and risk of childhood onset insulin dependent (type I) diabetes: population based case-control study. BMJ (Clinical Research Ed.), 313(7066), pp. 1174-7.
Dahlquist G, Bennich SS, Källén B. Intrauterine Growth Pattern and Risk of Childhood Onset Insulin Dependent (type I) Diabetes: Population Based Case-control Study. BMJ. 1996 Nov 9;313(7066):1174-7. PubMed PMID: 8916747.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Intrauterine growth pattern and risk of childhood onset insulin dependent (type I) diabetes: population based case-control study. AU - Dahlquist,G, AU - Bennich,S S, AU - Källén,B, PY - 1996/11/9/pubmed PY - 1996/11/9/medline PY - 1996/11/9/entrez SP - 1174 EP - 7 JF - BMJ (Clinical research ed.) JO - BMJ VL - 313 IS - 7066 N2 - OBJECTIVE: To investigate whether prenatal growth affects the risk of development of childhood onset insulin dependent (type I) diabetes mellitus. DESIGN: Population based case-control study. SETTING: Data from a nationwide childhood diabetes case register were linked with data from the nationwide Swedish Medical Birth Registry. SUBJECTS: Data from a total of 4584 diabetic children born after 1973 and diagnosed with diabetes from 1978 to 1992 were studied. For each child with insulin dependent diabetes three control children were randomly selected from among all infants born in the same year and at the same hospital as the proband. MAIN OUTCOME MEASURES: Birth weight, gestation, maternal age and parity, number of previous spontaneous abortions, and sex specific birth weight by gestational week expressed as multiples of the standard deviation (SD). RESULTS: There was a clear trend in the odds ratio for childhood onset diabetes according to SD of birth weight. The odds ratio (95% confidence interval) for small for gestational age after stratification for maternal age, parity, smoking habits, and maternal diabetes was 0.81 (0.65 to 0.99) and for large for gestational age after similar stratification was 1.20 (1.02 to 1.42). CONCLUSIONS: Intrauterine conditions that affect prenatal growth seem also to affect the risk of development of childhood diabetes in the way previously described for postnatal growth: a poor growth decreases and an excess growth increases the risk. The mechanism for this association is unclear. SN - 0959-8138 UR - https://www.unboundmedicine.com/medline/citation/8916747/Intrauterine_growth_pattern_and_risk_of_childhood_onset_insulin_dependent__type_I__diabetes:_population_based_case_control_study_ L2 - http://www.bmj.com/cgi/pmidlookup?view=long&pmid=8916747 DB - PRIME DP - Unbound Medicine ER -