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Sodium lauryl sulfate (SLS) induced irritant contact dermatitis: a correlation study between ceramides and in vivo parameters of irritation.
Contact Dermatitis. 1996 Aug; 35(2):86-91.CD

Abstract

Sodium lauryl sulfate (SLS), a surfactant frequently used in the induction of experimental irritant contact dermatitis in animals and in humans, characteristically induces a dose-related increase in TEWL (transepidermal water loss). Ceramides are considered to be important in the regulation of the skin barrier. We therefore examined the relationship between initial ceramide content of stratum corneum and induced changes in skin color (erythema) and barrier function, after SLS application under occlusion (1% and 3% in water) to the forearm of 14 volunteers. Stratum corneum sheets were removed, stratum corneum lipids extracted, and ceramide composition determined from chromatograms (TLC) using densitometry. After determining baseline skin color and TEWL at each area, 2 samples of stratum corneum were obtained from each volunteer. Clinical and instrumental controls of the SLS-induced irritation were performed at 24, 48, 72 and 96 h. Erythema was evaluated by colorimetry: barrier impairment by changes in TEWL. We found inverse correlations between baseline ceramide 61 (weight) and the 24 h erythema score for SLS 3%, between ceramide 1 and 24 h TEWL, and between ceramide 611 and 72 h TEWL for SLS 3%. Our findings suggest that low levels of these ceramides may determine a proclivity to SLS-induced irritant contact dermatitis.

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Authors+Show Affiliations

di Nardo A
Department of Dermatology, University of Modena, Italy.
Sugino K
No affiliation info available
Wertz P
No affiliation info available
Ademola J
No affiliation info available
Maibach HI
No affiliation info available

MeSH

AdultAnalysis of VarianceBiological AssayCase-Control StudiesCeramidesColorimetryDermatitis, IrritantDisease SusceptibilityEpidermisErythemaFemaleHumansLinear ModelsSkin AbsorptionSodium Dodecyl SulfateSurface-Active AgentsWater Loss, Insensible

Pub Type(s)

Journal Article

Language

eng

PubMed ID

8917825

Citation

di Nardo, A, et al. "Sodium Lauryl Sulfate (SLS) Induced Irritant Contact Dermatitis: a Correlation Study Between Ceramides and in Vivo Parameters of Irritation." Contact Dermatitis, vol. 35, no. 2, 1996, pp. 86-91.
di Nardo A, Sugino K, Wertz P, et al. Sodium lauryl sulfate (SLS) induced irritant contact dermatitis: a correlation study between ceramides and in vivo parameters of irritation. Contact Dermatitis. 1996;35(2):86-91.
di Nardo, A., Sugino, K., Wertz, P., Ademola, J., & Maibach, H. I. (1996). Sodium lauryl sulfate (SLS) induced irritant contact dermatitis: a correlation study between ceramides and in vivo parameters of irritation. Contact Dermatitis, 35(2), 86-91.
di Nardo A, et al. Sodium Lauryl Sulfate (SLS) Induced Irritant Contact Dermatitis: a Correlation Study Between Ceramides and in Vivo Parameters of Irritation. Contact Dermatitis. 1996;35(2):86-91. PubMed PMID: 8917825.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Sodium lauryl sulfate (SLS) induced irritant contact dermatitis: a correlation study between ceramides and in vivo parameters of irritation. AU - di Nardo,A, AU - Sugino,K, AU - Wertz,P, AU - Ademola,J, AU - Maibach,H I, PY - 1996/8/1/pubmed PY - 1996/8/1/medline PY - 1996/8/1/entrez SP - 86 EP - 91 JF - Contact dermatitis JO - Contact Dermatitis VL - 35 IS - 2 N2 - Sodium lauryl sulfate (SLS), a surfactant frequently used in the induction of experimental irritant contact dermatitis in animals and in humans, characteristically induces a dose-related increase in TEWL (transepidermal water loss). Ceramides are considered to be important in the regulation of the skin barrier. We therefore examined the relationship between initial ceramide content of stratum corneum and induced changes in skin color (erythema) and barrier function, after SLS application under occlusion (1% and 3% in water) to the forearm of 14 volunteers. Stratum corneum sheets were removed, stratum corneum lipids extracted, and ceramide composition determined from chromatograms (TLC) using densitometry. After determining baseline skin color and TEWL at each area, 2 samples of stratum corneum were obtained from each volunteer. Clinical and instrumental controls of the SLS-induced irritation were performed at 24, 48, 72 and 96 h. Erythema was evaluated by colorimetry: barrier impairment by changes in TEWL. We found inverse correlations between baseline ceramide 61 (weight) and the 24 h erythema score for SLS 3%, between ceramide 1 and 24 h TEWL, and between ceramide 611 and 72 h TEWL for SLS 3%. Our findings suggest that low levels of these ceramides may determine a proclivity to SLS-induced irritant contact dermatitis. SN - 0105-1873 UR - https://www.unboundmedicine.com/medline/citation/8917825/Sodium_lauryl_sulfate__SLS__induced_irritant_contact_dermatitis:_a_correlation_study_between_ceramides_and_in_vivo_parameters_of_irritation_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0105-1873&date=1996&volume=35&issue=2&spage=86 DB - PRIME DP - Unbound Medicine ER -