Tags

Type your tag names separated by a space and hit enter

Evaluation of cyst fluid analysis in the diagnosis of pancreatic cysts.
Ital J Gastroenterol. 1995 Dec; 27(9):479-83.IJ

Abstract

The pre-operative differential diagnosis of pancreatic cystic lesions is often difficult because of the lack of reliable clinical or radiological criteria. In order to improve the pre-operative recognition of these lesions, we performed cyst fluid analysis for enzymes (amylase and lipase), tumour markers (CEA, CA 19-9, CA 125, CA 72-4), and cytology in 52 pancreatic cysts. The cases included 21 pseudocysts, 12 mucinous cystic neoplasms, 7 ductal carcinomas, 7 benign lesions, and 5 rare malignancies observed from 1989 to 1994. Cyst fluid amylase, lipase, CEA, and CA 19-9 were variable and not discriminant between the groups. CA 125 fluid levels were high in 63% of malignant cysts. CA 72-4 fluid levels were significantly higher in mucinous cystic tumours than in pseudocysts (p < 0.0001), showing 95% specificity in detecting mucinous or malignant cysts. Cytology showed a sensitivity of 61% and a specificity of 100%. CA 72-4 determination raised the sensitivity of cytology to 92% in detecting mucinous or malignant cysts. This study confirms the low sensitivity of cytologic examination and low amylase specificity in distinguishing cystic neoplasms from pseudocysts. Cyst tumour markers assay is useful to improve the sensitivity of cytology, and CA 72-4 shows the best specificity in detecting (pre)malignant neoplasms.

Authors+Show Affiliations

Instituto di Semeiotica Chirurgica, Universita di Padova, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8919315

Citation

Sperti, C, et al. "Evaluation of Cyst Fluid Analysis in the Diagnosis of Pancreatic Cysts." The Italian Journal of Gastroenterology, vol. 27, no. 9, 1995, pp. 479-83.
Sperti C, Pasquali C, Guolo P, et al. Evaluation of cyst fluid analysis in the diagnosis of pancreatic cysts. Ital J Gastroenterol. 1995;27(9):479-83.
Sperti, C., Pasquali, C., Guolo, P., Caldart, T., Polverosi, R., Caroli, A., Colbertaldo, F., & Pedrazzoli, S. (1995). Evaluation of cyst fluid analysis in the diagnosis of pancreatic cysts. The Italian Journal of Gastroenterology, 27(9), 479-83.
Sperti C, et al. Evaluation of Cyst Fluid Analysis in the Diagnosis of Pancreatic Cysts. Ital J Gastroenterol. 1995;27(9):479-83. PubMed PMID: 8919315.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evaluation of cyst fluid analysis in the diagnosis of pancreatic cysts. AU - Sperti,C, AU - Pasquali,C, AU - Guolo,P, AU - Caldart,T, AU - Polverosi,R, AU - Caroli,A, AU - Colbertaldo,F, AU - Pedrazzoli,S, PY - 1995/12/1/pubmed PY - 1995/12/1/medline PY - 1995/12/1/entrez SP - 479 EP - 83 JF - The Italian journal of gastroenterology JO - Ital J Gastroenterol VL - 27 IS - 9 N2 - The pre-operative differential diagnosis of pancreatic cystic lesions is often difficult because of the lack of reliable clinical or radiological criteria. In order to improve the pre-operative recognition of these lesions, we performed cyst fluid analysis for enzymes (amylase and lipase), tumour markers (CEA, CA 19-9, CA 125, CA 72-4), and cytology in 52 pancreatic cysts. The cases included 21 pseudocysts, 12 mucinous cystic neoplasms, 7 ductal carcinomas, 7 benign lesions, and 5 rare malignancies observed from 1989 to 1994. Cyst fluid amylase, lipase, CEA, and CA 19-9 were variable and not discriminant between the groups. CA 125 fluid levels were high in 63% of malignant cysts. CA 72-4 fluid levels were significantly higher in mucinous cystic tumours than in pseudocysts (p < 0.0001), showing 95% specificity in detecting mucinous or malignant cysts. Cytology showed a sensitivity of 61% and a specificity of 100%. CA 72-4 determination raised the sensitivity of cytology to 92% in detecting mucinous or malignant cysts. This study confirms the low sensitivity of cytologic examination and low amylase specificity in distinguishing cystic neoplasms from pseudocysts. Cyst tumour markers assay is useful to improve the sensitivity of cytology, and CA 72-4 shows the best specificity in detecting (pre)malignant neoplasms. SN - 0392-0623 UR - https://www.unboundmedicine.com/medline/citation/8919315/Evaluation_of_cyst_fluid_analysis_in_the_diagnosis_of_pancreatic_cysts_ L2 - https://antibodies.cancer.gov/detail/CPTC-MUC16-1 DB - PRIME DP - Unbound Medicine ER -