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Serum levels of soluble receptors for tumor necrosis factor (p55 and p75 sTNFr) in endometrial cancer.
Anticancer Res. 1996 Sep-Oct; 16(5B):3125-8.AR

Abstract

The pretreatment serum levels of the soluble receptors for tumor necrosis factor (p55 and p75 sTNFr) were retrospectively measured in 38 patients with endometrial cancer and 55 patients with benign uterine diseases as controls. Serum p55 and p75 sTNFr levels were significantly higher in patients with endometrial cancer (median = 2.4 ng/ml, range = 1.4-6.8 ng/ml, and median = 7.1 ng/ml, range = 2.5-19.5 ng/ml, respectively) than in controls (median = 1.7 ng/ml, range = 0.5-4.0 ng/ml, p < 0.0001, and median = 5.2 ng/ml, range = 2.6-21.9 ng/ml, p = 0.03, respectively). In the former, serum p55 and p75 sTNFr values correlated with the extent of disease (stage III-IV versus I-II: p = 0.04 and p = 0.03, respectively). Among the 23 patients with stage I endometrial cancer who underwent initial surgery, the preoperative serum levels of both receptors correlated with the histologic grade and myometrial invasion but not with the clinical outcome. In conclusion, a stage-dependent release of the soluble receptors for TNF into the bloodstream occurs in patients with endometrial cancer.

Authors+Show Affiliations

Department of Gynecology and Obstetrics, University of Pisa, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

8920779

Citation

Gadducci, A, et al. "Serum Levels of Soluble Receptors for Tumor Necrosis Factor (p55 and P75 sTNFr) in Endometrial Cancer." Anticancer Research, vol. 16, no. 5B, 1996, pp. 3125-8.
Gadducci A, Ferdeghini M, Fanucchi A, et al. Serum levels of soluble receptors for tumor necrosis factor (p55 and p75 sTNFr) in endometrial cancer. Anticancer Res. 1996;16(5B):3125-8.
Gadducci, A., Ferdeghini, M., Fanucchi, A., Annicchiarico, C., Prato, B., Prontera, C., Facchini, V., & Genazzani, A. R. (1996). Serum levels of soluble receptors for tumor necrosis factor (p55 and p75 sTNFr) in endometrial cancer. Anticancer Research, 16(5B), 3125-8.
Gadducci A, et al. Serum Levels of Soluble Receptors for Tumor Necrosis Factor (p55 and P75 sTNFr) in Endometrial Cancer. Anticancer Res. 1996 Sep-Oct;16(5B):3125-8. PubMed PMID: 8920779.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Serum levels of soluble receptors for tumor necrosis factor (p55 and p75 sTNFr) in endometrial cancer. AU - Gadducci,A, AU - Ferdeghini,M, AU - Fanucchi,A, AU - Annicchiarico,C, AU - Prato,B, AU - Prontera,C, AU - Facchini,V, AU - Genazzani,A R, PY - 1996/9/1/pubmed PY - 1996/9/1/medline PY - 1996/9/1/entrez SP - 3125 EP - 8 JF - Anticancer research JO - Anticancer Res VL - 16 IS - 5B N2 - The pretreatment serum levels of the soluble receptors for tumor necrosis factor (p55 and p75 sTNFr) were retrospectively measured in 38 patients with endometrial cancer and 55 patients with benign uterine diseases as controls. Serum p55 and p75 sTNFr levels were significantly higher in patients with endometrial cancer (median = 2.4 ng/ml, range = 1.4-6.8 ng/ml, and median = 7.1 ng/ml, range = 2.5-19.5 ng/ml, respectively) than in controls (median = 1.7 ng/ml, range = 0.5-4.0 ng/ml, p < 0.0001, and median = 5.2 ng/ml, range = 2.6-21.9 ng/ml, p = 0.03, respectively). In the former, serum p55 and p75 sTNFr values correlated with the extent of disease (stage III-IV versus I-II: p = 0.04 and p = 0.03, respectively). Among the 23 patients with stage I endometrial cancer who underwent initial surgery, the preoperative serum levels of both receptors correlated with the histologic grade and myometrial invasion but not with the clinical outcome. In conclusion, a stage-dependent release of the soluble receptors for TNF into the bloodstream occurs in patients with endometrial cancer. SN - 0250-7005 UR - https://www.unboundmedicine.com/medline/citation/8920779/Serum_levels_of_soluble_receptors_for_tumor_necrosis_factor__p55_and_p75_sTNFr__in_endometrial_cancer_ L2 - http://www.diseaseinfosearch.org/result/8312 DB - PRIME DP - Unbound Medicine ER -