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Association between serum sialic acid concentration and carotid atherosclerosis measured by B-mode ultrasound. The ARIC Investigators. Atherosclerosis Risk in Communities Study.
Int J Epidemiol 1996; 25(5):953-8IJ

Abstract

BACKGROUND

Previous studies have shown that the serum level of sialic acid is associated positively with mortality from coronary disease and stroke. In this study its relation with carotid atherosclerosis was evaluated.

METHODS

From the Atherosclerosis Risk in Communities (ARIC) Study, 323 cases with carotid intima-media wall thickness above the 90th percentile (measured with B-mode ultrasound) were matched 1:1 with controls without atherosclerosis. Serum sialic acid, plasma LDL and HDL cholesterol, serum insulin concentrations, blood pressure, antihypertensive medication use, and smoking status were used to assess the independent contribution of the sialic acid level to carotid atherosclerosis.

RESULTS

The mean (SD) serum sialic acid concentration was 75.0 (9.7) mg/dl in cases and 70.7 (8.9) mg/dl in controls (P = 0.0001). In a conditional logistic model with adjustment for age, LDL-cholesterol, HDL-cholesterol, serum insulin, smoking and hypertension, the odds ratio associated with sialic acid above the 75th percentile (> or = 78.3 mg/dl) versus below was 1.65 with a 95% confidence interval of 1.01-2.70.

CONCLUSION

The sialic acid level is correlated with the presence of carotid atherosclerosis, independently of major cardiovascular disease risk factors. The biological mechanism behind this association is not resolved.

Authors+Show Affiliations

Division of Epidemiology, School of Public Health, University of Minnesota, Minneapolis, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

8921480

Citation

Råstam, L, et al. "Association Between Serum Sialic Acid Concentration and Carotid Atherosclerosis Measured By B-mode Ultrasound. the ARIC Investigators. Atherosclerosis Risk in Communities Study." International Journal of Epidemiology, vol. 25, no. 5, 1996, pp. 953-8.
Råstam L, Lindberg G, Folsom AR, et al. Association between serum sialic acid concentration and carotid atherosclerosis measured by B-mode ultrasound. The ARIC Investigators. Atherosclerosis Risk in Communities Study. Int J Epidemiol. 1996;25(5):953-8.
Råstam, L., Lindberg, G., Folsom, A. R., Burke, G. L., Nilsson-Ehle, P., & Lundblad, A. (1996). Association between serum sialic acid concentration and carotid atherosclerosis measured by B-mode ultrasound. The ARIC Investigators. Atherosclerosis Risk in Communities Study. International Journal of Epidemiology, 25(5), pp. 953-8.
Råstam L, et al. Association Between Serum Sialic Acid Concentration and Carotid Atherosclerosis Measured By B-mode Ultrasound. the ARIC Investigators. Atherosclerosis Risk in Communities Study. Int J Epidemiol. 1996;25(5):953-8. PubMed PMID: 8921480.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association between serum sialic acid concentration and carotid atherosclerosis measured by B-mode ultrasound. The ARIC Investigators. Atherosclerosis Risk in Communities Study. AU - Råstam,L, AU - Lindberg,G, AU - Folsom,A R, AU - Burke,G L, AU - Nilsson-Ehle,P, AU - Lundblad,A, PY - 1996/10/1/pubmed PY - 1996/10/1/medline PY - 1996/10/1/entrez SP - 953 EP - 8 JF - International journal of epidemiology JO - Int J Epidemiol VL - 25 IS - 5 N2 - BACKGROUND: Previous studies have shown that the serum level of sialic acid is associated positively with mortality from coronary disease and stroke. In this study its relation with carotid atherosclerosis was evaluated. METHODS: From the Atherosclerosis Risk in Communities (ARIC) Study, 323 cases with carotid intima-media wall thickness above the 90th percentile (measured with B-mode ultrasound) were matched 1:1 with controls without atherosclerosis. Serum sialic acid, plasma LDL and HDL cholesterol, serum insulin concentrations, blood pressure, antihypertensive medication use, and smoking status were used to assess the independent contribution of the sialic acid level to carotid atherosclerosis. RESULTS: The mean (SD) serum sialic acid concentration was 75.0 (9.7) mg/dl in cases and 70.7 (8.9) mg/dl in controls (P = 0.0001). In a conditional logistic model with adjustment for age, LDL-cholesterol, HDL-cholesterol, serum insulin, smoking and hypertension, the odds ratio associated with sialic acid above the 75th percentile (> or = 78.3 mg/dl) versus below was 1.65 with a 95% confidence interval of 1.01-2.70. CONCLUSION: The sialic acid level is correlated with the presence of carotid atherosclerosis, independently of major cardiovascular disease risk factors. The biological mechanism behind this association is not resolved. SN - 0300-5771 UR - https://www.unboundmedicine.com/medline/citation/8921480/Association_between_serum_sialic_acid_concentration_and_carotid_atherosclerosis_measured_by_B_mode_ultrasound__The_ARIC_Investigators__Atherosclerosis_Risk_in_Communities_Study_ L2 - https://academic.oup.com/ije/article-lookup/doi/10.1093/ije/25.5.953 DB - PRIME DP - Unbound Medicine ER -