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Fecal and rectal mucosal diacylglycerol concentrations and epithelial proliferative kinetics.
Cancer Epidemiol Biomarkers Prev. 1996 Nov; 5(11):937-40.CE

Abstract

Fecal diacylglycerol (DAG) concentrations have been suggested as biomarkers for colonic neoplasia because of their potential to be absorbed in the colon and to stimulate epithelial cell proliferation. The interrelationships among nutrient intake, fecal and mucosal DAG, and colonic proliferative markers have not previously been studied. We designed a pilot study to evaluate the feasibility of evaluating these interrelationships in 12 volunteers who had a history of colonic adenomatous polyposis. Total mucosal DAG concentrations were not related to fecal DAG concentrations, but mucosal DAG correlated inversely with the whole crypt labeling index. Dietary intake did not alter fecal DAG concentrations. However, the percentage of calories from dietary fat correlated positively with the whole crypt labeling index. Fiber and calcium intake showed a positive correlation with the labeling index in the upper 40% of the crypt. The present pilot study failed to demonstrate a correlation between dietary components and fecal and total mucosal DAG. Additional studies relating fecal DAG with mucosal proliferation will require the evaluation of DAG concentrations in subcellular compartments of mucosal cells and/or measurement of fecal DAG fatty acid composition.

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Authors+Show Affiliations

Holt PR
Gastrointestinal Division, St. Luke's-Roosevelt Hospital Center, New York, New York 10025, USA.
Moss SF
No affiliation info available
Whelan R
No affiliation info available
Guss J
No affiliation info available
Gilman J
No affiliation info available
Lipkin M
No affiliation info available

MeSH

Adenomatous Polyposis ColiAgedCell DivisionDietDiglyceridesFeasibility StudiesFecesHumansIntestinal MucosaMiddle AgedPilot ProjectsRectumRisk Factors

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8922305

Citation

Holt, P R., et al. "Fecal and Rectal Mucosal Diacylglycerol Concentrations and Epithelial Proliferative Kinetics." Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, vol. 5, no. 11, 1996, pp. 937-40.
Holt PR, Moss SF, Whelan R, et al. Fecal and rectal mucosal diacylglycerol concentrations and epithelial proliferative kinetics. Cancer Epidemiol Biomarkers Prev. 1996;5(11):937-40.
Holt, P. R., Moss, S. F., Whelan, R., Guss, J., Gilman, J., & Lipkin, M. (1996). Fecal and rectal mucosal diacylglycerol concentrations and epithelial proliferative kinetics. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, 5(11), 937-40.
Holt PR, et al. Fecal and Rectal Mucosal Diacylglycerol Concentrations and Epithelial Proliferative Kinetics. Cancer Epidemiol Biomarkers Prev. 1996;5(11):937-40. PubMed PMID: 8922305.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Fecal and rectal mucosal diacylglycerol concentrations and epithelial proliferative kinetics. AU - Holt,P R, AU - Moss,S F, AU - Whelan,R, AU - Guss,J, AU - Gilman,J, AU - Lipkin,M, PY - 1996/11/1/pubmed PY - 1996/11/1/medline PY - 1996/11/1/entrez SP - 937 EP - 40 JF - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology JO - Cancer Epidemiol Biomarkers Prev VL - 5 IS - 11 N2 - Fecal diacylglycerol (DAG) concentrations have been suggested as biomarkers for colonic neoplasia because of their potential to be absorbed in the colon and to stimulate epithelial cell proliferation. The interrelationships among nutrient intake, fecal and mucosal DAG, and colonic proliferative markers have not previously been studied. We designed a pilot study to evaluate the feasibility of evaluating these interrelationships in 12 volunteers who had a history of colonic adenomatous polyposis. Total mucosal DAG concentrations were not related to fecal DAG concentrations, but mucosal DAG correlated inversely with the whole crypt labeling index. Dietary intake did not alter fecal DAG concentrations. However, the percentage of calories from dietary fat correlated positively with the whole crypt labeling index. Fiber and calcium intake showed a positive correlation with the labeling index in the upper 40% of the crypt. The present pilot study failed to demonstrate a correlation between dietary components and fecal and total mucosal DAG. Additional studies relating fecal DAG with mucosal proliferation will require the evaluation of DAG concentrations in subcellular compartments of mucosal cells and/or measurement of fecal DAG fatty acid composition. SN - 1055-9965 UR - https://www.unboundmedicine.com/medline/citation/8922305/Fecal_and_rectal_mucosal_diacylglycerol_concentrations_and_epithelial_proliferative_kinetics_ L2 - http://cebp.aacrjournals.org/cgi/pmidlookup?view=long&pmid=8922305 DB - PRIME DP - Unbound Medicine ER -