Tags

Type your tag names separated by a space and hit enter

Skeletal responsiveness to thyroid hormone is not altered at menopause.
Bone 1996; 19(5):557-64BONE

Abstract

Hyperthyroidism is characterized by increased bone turnover and resorptive activity. Similar changes in remodeling are seen after menopause. To study the role of thyroid hormone in the menopause-related changes in bone metabolism, we investigated thyroid status and the sensitivity of bone to thyroid hormone in 14 premenopausal and 15 early postmenopausal women. Triiodothyronine (T3) was administered to the two groups as 20 micrograms doses three times daily for 7 days. The skeletal response was assessed by monitoring bone alkaline phosphatase (BAP), osteocalcin (BGP), pyridinium crosslinked telopeptide domain of type I collagen (ICTP) in serum and urinary excretion of hydroxyproline (OHP), pyridinoline (PYR), and deoxypyridinoline (DPR) at days 0, 8, 15, and 57. The early postmenopausal women had increased bone turnover as reflected in sBAP (p < 0.05), sBGP (p < 0.05), and uOHP (p < 0.01) when compared with premenopausal controls. T3 stimulation of early postmenopausal and premenopausal women significantly increased the markers of bone resorption: sICTP (56% vs. 44%), uOHP (45% in both groups), and UPYR (83% vs. 17%) without any significant differences between groups. Of the formative markers, only sBGP increased significantly after stimulation (34% vs. 41%), but both sBGP and sBAP displayed significant increases from days 15 to 57. Thus, stimulation with thyroid hormone results in an immediate stimulation of ongoing bone formation and bone resorption, but also initiation of new remodeling which, after 8 weeks, reached the formative phase. PTH decreased (p < 0.01) in both groups but serum calcium and serum phosphate were unaltered. In conclusion, menopause is not characterized by altered levels of thyroid hormones or altered skeletal responsiveness to thyroid hormones.

Authors+Show Affiliations

Aarhus Bone and Mineral Research Group, University Department of Endocrinology and Metabolism, Denmark.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Controlled Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8922657

Citation

Langdahl, B L., et al. "Skeletal Responsiveness to Thyroid Hormone Is Not Altered at Menopause." Bone, vol. 19, no. 5, 1996, pp. 557-64.
Langdahl BL, Loft AG, Møller N, et al. Skeletal responsiveness to thyroid hormone is not altered at menopause. Bone. 1996;19(5):557-64.
Langdahl, B. L., Loft, A. G., Møller, N., Weeke, J., Eriksen, E. F., Mosekilde, L., & Charles, P. (1996). Skeletal responsiveness to thyroid hormone is not altered at menopause. Bone, 19(5), pp. 557-64.
Langdahl BL, et al. Skeletal Responsiveness to Thyroid Hormone Is Not Altered at Menopause. Bone. 1996;19(5):557-64. PubMed PMID: 8922657.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Skeletal responsiveness to thyroid hormone is not altered at menopause. AU - Langdahl,B L, AU - Loft,A G, AU - Møller,N, AU - Weeke,J, AU - Eriksen,E F, AU - Mosekilde,L, AU - Charles,P, PY - 1996/11/1/pubmed PY - 1996/11/1/medline PY - 1996/11/1/entrez SP - 557 EP - 64 JF - Bone JO - Bone VL - 19 IS - 5 N2 - Hyperthyroidism is characterized by increased bone turnover and resorptive activity. Similar changes in remodeling are seen after menopause. To study the role of thyroid hormone in the menopause-related changes in bone metabolism, we investigated thyroid status and the sensitivity of bone to thyroid hormone in 14 premenopausal and 15 early postmenopausal women. Triiodothyronine (T3) was administered to the two groups as 20 micrograms doses three times daily for 7 days. The skeletal response was assessed by monitoring bone alkaline phosphatase (BAP), osteocalcin (BGP), pyridinium crosslinked telopeptide domain of type I collagen (ICTP) in serum and urinary excretion of hydroxyproline (OHP), pyridinoline (PYR), and deoxypyridinoline (DPR) at days 0, 8, 15, and 57. The early postmenopausal women had increased bone turnover as reflected in sBAP (p < 0.05), sBGP (p < 0.05), and uOHP (p < 0.01) when compared with premenopausal controls. T3 stimulation of early postmenopausal and premenopausal women significantly increased the markers of bone resorption: sICTP (56% vs. 44%), uOHP (45% in both groups), and UPYR (83% vs. 17%) without any significant differences between groups. Of the formative markers, only sBGP increased significantly after stimulation (34% vs. 41%), but both sBGP and sBAP displayed significant increases from days 15 to 57. Thus, stimulation with thyroid hormone results in an immediate stimulation of ongoing bone formation and bone resorption, but also initiation of new remodeling which, after 8 weeks, reached the formative phase. PTH decreased (p < 0.01) in both groups but serum calcium and serum phosphate were unaltered. In conclusion, menopause is not characterized by altered levels of thyroid hormones or altered skeletal responsiveness to thyroid hormones. SN - 8756-3282 UR - https://www.unboundmedicine.com/medline/citation/8922657/Skeletal_responsiveness_to_thyroid_hormone_is_not_altered_at_menopause_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S8756328296002475 DB - PRIME DP - Unbound Medicine ER -