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Relationship between gastric acid secretion, histopathology, and cell proliferation kinetics in human gastric mucosa.
Gastroenterology. 1977 Sep; 73(3):453-6.G

Abstract

Cell proliferation of gastric antral and fundic mucosa was studied in a series of patients with different gastric diseases. After in vitro incubation of endoscopic biopsies with tritiated thymidine, radioautographs were prepared by the dipping technique. The labeling indices were estimated, and the biopsies were classified according to the degree of gastritis. The peak acid output after "maximal" stimulation with histamine was also determined. A highly significant inverse correlation between peak acid output and the labeling indices in both antral and fundic mucosa was demonstrated. The correlation between the degree of gastritis and the labeling indices in antral and fundic mucosa was also statistically significant. The results indicate that a significant inverse relationship exists between the acid secretory capacity of the gastric mucosa and the rate of cell proliferation in both antral and fundic mucosa. Furthermore, the data suggest that an increasing degree of gastritis in human gastric mucosa is followed by an increased rate of epithelial cell proliferation.

Authors

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Pub Type(s)

Journal Article

Language

eng

PubMed ID

892341

Citation

Hansen, O H., et al. "Relationship Between Gastric Acid Secretion, Histopathology, and Cell Proliferation Kinetics in Human Gastric Mucosa." Gastroenterology, vol. 73, no. 3, 1977, pp. 453-6.
Hansen OH, Johansen A, Larsen JK, et al. Relationship between gastric acid secretion, histopathology, and cell proliferation kinetics in human gastric mucosa. Gastroenterology. 1977;73(3):453-6.
Hansen, O. H., Johansen, A., Larsen, J. K., Pedersen, T., & Svendsen, L. B. (1977). Relationship between gastric acid secretion, histopathology, and cell proliferation kinetics in human gastric mucosa. Gastroenterology, 73(3), 453-6.
Hansen OH, et al. Relationship Between Gastric Acid Secretion, Histopathology, and Cell Proliferation Kinetics in Human Gastric Mucosa. Gastroenterology. 1977;73(3):453-6. PubMed PMID: 892341.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Relationship between gastric acid secretion, histopathology, and cell proliferation kinetics in human gastric mucosa. AU - Hansen,O H, AU - Johansen,A, AU - Larsen,J K, AU - Pedersen,T, AU - Svendsen,L B, PY - 1977/9/1/pubmed PY - 1977/9/1/medline PY - 1977/9/1/entrez SP - 453 EP - 6 JF - Gastroenterology JO - Gastroenterology VL - 73 IS - 3 N2 - Cell proliferation of gastric antral and fundic mucosa was studied in a series of patients with different gastric diseases. After in vitro incubation of endoscopic biopsies with tritiated thymidine, radioautographs were prepared by the dipping technique. The labeling indices were estimated, and the biopsies were classified according to the degree of gastritis. The peak acid output after "maximal" stimulation with histamine was also determined. A highly significant inverse correlation between peak acid output and the labeling indices in both antral and fundic mucosa was demonstrated. The correlation between the degree of gastritis and the labeling indices in antral and fundic mucosa was also statistically significant. The results indicate that a significant inverse relationship exists between the acid secretory capacity of the gastric mucosa and the rate of cell proliferation in both antral and fundic mucosa. Furthermore, the data suggest that an increasing degree of gastritis in human gastric mucosa is followed by an increased rate of epithelial cell proliferation. SN - 0016-5085 UR - https://www.unboundmedicine.com/medline/citation/892341/Relationship_between_gastric_acid_secretion_histopathology_and_cell_proliferation_kinetics_in_human_gastric_mucosa_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0016508577002480 DB - PRIME DP - Unbound Medicine ER -