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The effects of 18 alpha,beta-glycyrrhetinic acid on the hormonal induction of tyrosine aminotransferase in rat primary cultured hepatocytes.
Planta Med. 1996 Oct; 62(5):410-2.PM

Abstract

The effects of 18 alpha,beta-glycyrrhetinic acid (18 alpha,beta-GA) on the hormonal induction of tyrosine aminotransferase (TAT) in rat primary cultured hepatocytes were investigated. Dexamethassone or glucagon used alone caused an increase in enzyme activity, and in combination their effects were additive. In the 18 beta-GA hepatocytes pretreated for 6 h, the dexamethasone-induced increase in the enzyme activity was slightly reduced in a dose-independent manner, and the glucagon-induced increase and the combined effects of these two inducers were significantly reduced in a dose-dependent manner. On the other hand, 18 alpha-GA, which was the isomer of 18 beta-GA, exerted no influence on the hormonally mediated increase in enzyme activity. Moreover, 18 beta-GA reduced the glucose release induced by glucagon in a dose-dependent manner and 18 alpha-GA did not. These results suggested that 18 beta-GA reduced the glucagon-mediated cell response in rat hepatocytes.

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Authors+Show Affiliations

Nose M
Department of Pharmacognosy and Plant Chemistry, Faculty of Pharmaceutical Sciences, Nagoya City University, Japan.
Ito M
No affiliation info available
Koide T
No affiliation info available
Terawaki K
No affiliation info available
Ogihara Y
No affiliation info available

MeSH

AnimalsCells, CulturedDexamethasoneEnzyme InductionGlucagonGlucoseGlycyrrhetinic AcidLiverMalePlants, MedicinalRatsRats, WistarStereoisomerismTyrosine Transaminase

Pub Type(s)

Journal Article

Language

eng

PubMed ID

8923804

Citation

Nose, M, et al. "The Effects of 18 Alpha,beta-glycyrrhetinic Acid On the Hormonal Induction of Tyrosine Aminotransferase in Rat Primary Cultured Hepatocytes." Planta Medica, vol. 62, no. 5, 1996, pp. 410-2.
Nose M, Ito M, Koide T, et al. The effects of 18 alpha,beta-glycyrrhetinic acid on the hormonal induction of tyrosine aminotransferase in rat primary cultured hepatocytes. Planta Med. 1996;62(5):410-2.
Nose, M., Ito, M., Koide, T., Terawaki, K., & Ogihara, Y. (1996). The effects of 18 alpha,beta-glycyrrhetinic acid on the hormonal induction of tyrosine aminotransferase in rat primary cultured hepatocytes. Planta Medica, 62(5), 410-2.
Nose M, et al. The Effects of 18 Alpha,beta-glycyrrhetinic Acid On the Hormonal Induction of Tyrosine Aminotransferase in Rat Primary Cultured Hepatocytes. Planta Med. 1996;62(5):410-2. PubMed PMID: 8923804.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effects of 18 alpha,beta-glycyrrhetinic acid on the hormonal induction of tyrosine aminotransferase in rat primary cultured hepatocytes. AU - Nose,M, AU - Ito,M, AU - Koide,T, AU - Terawaki,K, AU - Ogihara,Y, PY - 1996/10/1/pubmed PY - 1996/10/1/medline PY - 1996/10/1/entrez SP - 410 EP - 2 JF - Planta medica JO - Planta Med VL - 62 IS - 5 N2 - The effects of 18 alpha,beta-glycyrrhetinic acid (18 alpha,beta-GA) on the hormonal induction of tyrosine aminotransferase (TAT) in rat primary cultured hepatocytes were investigated. Dexamethassone or glucagon used alone caused an increase in enzyme activity, and in combination their effects were additive. In the 18 beta-GA hepatocytes pretreated for 6 h, the dexamethasone-induced increase in the enzyme activity was slightly reduced in a dose-independent manner, and the glucagon-induced increase and the combined effects of these two inducers were significantly reduced in a dose-dependent manner. On the other hand, 18 alpha-GA, which was the isomer of 18 beta-GA, exerted no influence on the hormonally mediated increase in enzyme activity. Moreover, 18 beta-GA reduced the glucose release induced by glucagon in a dose-dependent manner and 18 alpha-GA did not. These results suggested that 18 beta-GA reduced the glucagon-mediated cell response in rat hepatocytes. SN - 0032-0943 UR - https://www.unboundmedicine.com/medline/citation/8923804/The_effects_of_18_alphabeta_glycyrrhetinic_acid_on_the_hormonal_induction_of_tyrosine_aminotransferase_in_rat_primary_cultured_hepatocytes_ L2 - https://www.thieme-connect.com/DOI/DOI?10.1055/s-2006-957927 DB - PRIME DP - Unbound Medicine ER -