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[Usefulness of calcium acetate as a chelating of phosphorus in patients in hemodialysis with secondary hyperthyroidism].
An Med Interna. 1995 Aug; 12(8):377-81.AM

Abstract

In this study, we prospectively evaluated the efficacy of calcium acetate in patients with chronic renal insufficiency on hemodialysis programme with secondary hyperparathyroidism and hyperphosphatemia, which are difficult to control by means of the usual finders (calcium carbonate and aluminium hydroxide) and who were treated with pulses of calcitriol. We studied 10 patients. The inclusion criteria were: a serum phosphorus higher than 6.5 mg/dl, a serum PTHi higher than 250 pg/ml and a serum calcium higher than 9.5. The former therapy was stopped at the time of the patient was included in the study. Calcium acetate was initially introduced with doses between 2.5-4 g/day according to previous calcium and phosphate values. Also, all patients were initially treated with intermittent subcutaneous bolus of Calcitriol were modified and adjusted according to serum concentrations of calcium, phosphorus and PTHi. The concentration of calcium in the dialyzed was of 1.25 mmol/l. Fortnightly total calcium, phosphate and alkaline phosphatase serum determinations and monthly aluminium and PTHi serum determinations were carried out. During the 6 months treatment, a decrease was observed in serum concentrations of phosphate (p < 0.01), aluminum (p < 0.02) and PTHi (p < 0.001) with no changes in the values of calcium (p = ns) nor alkaline phosphatase (p = ns). The incidence of hypercalcemia was low during the follow-up period (11% of all biochemical serum determinations) and was easily controlled. We can conclude that calcium acetate is a sure and effective finder of phosphorus with a very good tolerance. Administered together with pulses of calcitriol, and the use of a low calcium concentration in the dialysate, it does not increase the risk of hypercalcemia.

Authors+Show Affiliations

Unidad Trasplante Renal, Hospital Clinic, Universidad de Barcelona.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

spa

PubMed ID

8924527

Citation

Torregrosa Prats, J V., et al. "[Usefulness of Calcium Acetate as a Chelating of Phosphorus in Patients in Hemodialysis With Secondary Hyperthyroidism]." Anales De Medicina Interna (Madrid, Spain : 1984), vol. 12, no. 8, 1995, pp. 377-81.
Torregrosa Prats JV, Mas Mas M, Montesinos Ballestena M, et al. [Usefulness of calcium acetate as a chelating of phosphorus in patients in hemodialysis with secondary hyperthyroidism]. An Med Interna. 1995;12(8):377-81.
Torregrosa Prats, J. V., Mas Mas, M., Montesinos Ballestena, M., Casellas Bartumeus, J., & Campistol Plana, J. M. (1995). [Usefulness of calcium acetate as a chelating of phosphorus in patients in hemodialysis with secondary hyperthyroidism]. Anales De Medicina Interna (Madrid, Spain : 1984), 12(8), 377-81.
Torregrosa Prats JV, et al. [Usefulness of Calcium Acetate as a Chelating of Phosphorus in Patients in Hemodialysis With Secondary Hyperthyroidism]. An Med Interna. 1995;12(8):377-81. PubMed PMID: 8924527.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Usefulness of calcium acetate as a chelating of phosphorus in patients in hemodialysis with secondary hyperthyroidism]. AU - Torregrosa Prats,J V, AU - Mas Mas,M, AU - Montesinos Ballestena,M, AU - Casellas Bartumeus,J, AU - Campistol Plana,J M, PY - 1995/8/1/pubmed PY - 1995/8/1/medline PY - 1995/8/1/entrez SP - 377 EP - 81 JF - Anales de medicina interna (Madrid, Spain : 1984) JO - An Med Interna VL - 12 IS - 8 N2 - In this study, we prospectively evaluated the efficacy of calcium acetate in patients with chronic renal insufficiency on hemodialysis programme with secondary hyperparathyroidism and hyperphosphatemia, which are difficult to control by means of the usual finders (calcium carbonate and aluminium hydroxide) and who were treated with pulses of calcitriol. We studied 10 patients. The inclusion criteria were: a serum phosphorus higher than 6.5 mg/dl, a serum PTHi higher than 250 pg/ml and a serum calcium higher than 9.5. The former therapy was stopped at the time of the patient was included in the study. Calcium acetate was initially introduced with doses between 2.5-4 g/day according to previous calcium and phosphate values. Also, all patients were initially treated with intermittent subcutaneous bolus of Calcitriol were modified and adjusted according to serum concentrations of calcium, phosphorus and PTHi. The concentration of calcium in the dialyzed was of 1.25 mmol/l. Fortnightly total calcium, phosphate and alkaline phosphatase serum determinations and monthly aluminium and PTHi serum determinations were carried out. During the 6 months treatment, a decrease was observed in serum concentrations of phosphate (p < 0.01), aluminum (p < 0.02) and PTHi (p < 0.001) with no changes in the values of calcium (p = ns) nor alkaline phosphatase (p = ns). The incidence of hypercalcemia was low during the follow-up period (11% of all biochemical serum determinations) and was easily controlled. We can conclude that calcium acetate is a sure and effective finder of phosphorus with a very good tolerance. Administered together with pulses of calcitriol, and the use of a low calcium concentration in the dialysate, it does not increase the risk of hypercalcemia. SN - 0212-7199 UR - https://www.unboundmedicine.com/medline/citation/8924527/[Usefulness_of_calcium_acetate_as_a_chelating_of_phosphorus_in_patients_in_hemodialysis_with_secondary_hyperthyroidism]_ L2 - https://medlineplus.gov/kidneyfailure.html DB - PRIME DP - Unbound Medicine ER -