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Benefits of early postoperative enteral feeding in cancer patients.
Infusionsther Transfusionsmed 1995; 22(5):280-4IT

Abstract

OBJECTIVE

To evaluate the effect of the early postoperative administration of an enriched enteral diet in cancer patients.

DESIGN

Randomised controlled study.

SETTING

Surgical intensive care unit of a university hospital.

PATIENTS

77 consecutive patients undergoing curative surgery for gastric or pancreatic cancer.

INTERVENTIONS

Patients were randomised into 3 groups to receive: a standard enteral formula (n=24); the same formula enriched with arginine, RNA, and omega-3 fatty acids (n = 26), isonitrogen isocaloric total parenteral nutrition (n = 27). Enteral nutrition was started within 12 h following surgery. Infusion rate was progressively increased reaching the full regimen on postoperative day (POD) 4. On admission and on POD 1 and 8, the following measurements were performed: serum level of total iron-binding capacity, albumin, prealbumin, retinol-binding protein (RBP), and cholinesterase. Delayed hypersensitivity response (DHR), IgG, IgM, IgA, lymphocyte subsets. and monocyte phagocytosis ability were also evaluated. Bioelectrical impedance analysis was performed preoperatively and on POD 2, 7, and 11. The rate and severity of postoperative infections and the length of hospital stay were evaluated.

RESULTS

In all patients, a significant drop of nutritional and immunologic parameters was observed on POD 1. A significant increase of prealbumin (p<0.02), RBP (p<0.005), monocyte phagocytosis ability (p<0.001), and DHR (p<0.005) was found on POD 8 only in the group fed with the enriched diet. A significant reduction of severity of postoperative infections and length of postoperative stay was found in the group with the enriched diet compared to the other groups.

CONCLUSIONS

These data are suggestive of an improvement of the nutritional and immunologic status and clinical outcome in cancer patients who receive an enriched enteral diet in the early postoperative course.

Authors+Show Affiliations

Department of Surgery, Scientific Institute San Raffaele, University of Milan, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

8924741

Citation

Braga, M, et al. "Benefits of Early Postoperative Enteral Feeding in Cancer Patients." Infusionstherapie Und Transfusionsmedizin, vol. 22, no. 5, 1995, pp. 280-4.
Braga M, Vignali A, Gianotti L, et al. Benefits of early postoperative enteral feeding in cancer patients. Infusionsther Transfusionsmed. 1995;22(5):280-4.
Braga, M., Vignali, A., Gianotti, L., Cestari, A., Profili, M., & Di Carlo, V. (1995). Benefits of early postoperative enteral feeding in cancer patients. Infusionstherapie Und Transfusionsmedizin, 22(5), pp. 280-4.
Braga M, et al. Benefits of Early Postoperative Enteral Feeding in Cancer Patients. Infusionsther Transfusionsmed. 1995;22(5):280-4. PubMed PMID: 8924741.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Benefits of early postoperative enteral feeding in cancer patients. AU - Braga,M, AU - Vignali,A, AU - Gianotti,L, AU - Cestari,A, AU - Profili,M, AU - Di Carlo,V, PY - 1995/10/1/pubmed PY - 1995/10/1/medline PY - 1995/10/1/entrez SP - 280 EP - 4 JF - Infusionstherapie und Transfusionsmedizin JO - Infusionsther Transfusionsmed VL - 22 IS - 5 N2 - OBJECTIVE: To evaluate the effect of the early postoperative administration of an enriched enteral diet in cancer patients. DESIGN: Randomised controlled study. SETTING: Surgical intensive care unit of a university hospital. PATIENTS: 77 consecutive patients undergoing curative surgery for gastric or pancreatic cancer. INTERVENTIONS: Patients were randomised into 3 groups to receive: a standard enteral formula (n=24); the same formula enriched with arginine, RNA, and omega-3 fatty acids (n = 26), isonitrogen isocaloric total parenteral nutrition (n = 27). Enteral nutrition was started within 12 h following surgery. Infusion rate was progressively increased reaching the full regimen on postoperative day (POD) 4. On admission and on POD 1 and 8, the following measurements were performed: serum level of total iron-binding capacity, albumin, prealbumin, retinol-binding protein (RBP), and cholinesterase. Delayed hypersensitivity response (DHR), IgG, IgM, IgA, lymphocyte subsets. and monocyte phagocytosis ability were also evaluated. Bioelectrical impedance analysis was performed preoperatively and on POD 2, 7, and 11. The rate and severity of postoperative infections and the length of hospital stay were evaluated. RESULTS: In all patients, a significant drop of nutritional and immunologic parameters was observed on POD 1. A significant increase of prealbumin (p<0.02), RBP (p<0.005), monocyte phagocytosis ability (p<0.001), and DHR (p<0.005) was found on POD 8 only in the group fed with the enriched diet. A significant reduction of severity of postoperative infections and length of postoperative stay was found in the group with the enriched diet compared to the other groups. CONCLUSIONS: These data are suggestive of an improvement of the nutritional and immunologic status and clinical outcome in cancer patients who receive an enriched enteral diet in the early postoperative course. SN - 1019-8466 UR - https://www.unboundmedicine.com/medline/citation/8924741/Benefits_of_early_postoperative_enteral_feeding_in_cancer_patients_ L2 - https://ClinicalTrials.gov/search/term=8924741 [PUBMED-IDS] DB - PRIME DP - Unbound Medicine ER -