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Effect of capsaicin inhalation on methacholine responsiveness in normal subjects.
Clin Auton Res. 1996 Feb; 6(1):45-8.CA

Abstract

It has been reported that capsaicin stimulates bronchial C-fibers to release neuropeptides and enhances bronchial responsiveness in animal studies. This study was conducted to examine the effect of inhaled capsaicin on bronchial responsiveness in humans. A provocative concentration of methacholine producing a 20% fall in forced expiratory volume in one second (PC20-FEV1) was measured before and one hour after, one minute inhalation of 15.6 microM capsaicin solution (capsaicin day) or saline (saline day) in seven normal subjects whose PC20-FEV1 values were 40 mg/ml or less. Geometric mean value of PC20-FEV1 measured one hour after saline inhalation following pretreatment methacholine challenge was 89.3 (GSEM, 1.69) mg/ml which was significantly (p = 0.018) greater than that of the pre-treatment methacholine challenge [19.1 (GSEM, 1.37) mg/ml] on a saline day. However, PC20-FEV1 was not different before and one hour after inhalation of capsaicin [18.1 (GSEM, 1.40) and 23.1 (GSEM, 1.80) mg/ml] on a capsaicin day. The PC20-FEV1 value of the post-treatment methacholine test was significantly (p = 0.0277) lower after capsaicin inhalation than after saline inhalation while the value of pre-treatment methacholine provocation was not different between capsaicin and saline days. Change of the post-treatment PC20-FEV1 from the pre-treatment value shown as doubling concentrations was 0.35 +/- 0.60 on a capsaicin day which was significantly lower than that (2.23 +/- 0.47) on a saline day. These results confirm the decreased responses to repeated inhalation of methacholine (methacholine tachyphylaxis) in normal subjects and indicate that capsaicin inhalation reduces the methacholine tachyphylaxis.

Authors+Show Affiliations

Third Department of Internal Medicine, Kanazawa University School of Medicine, Japan.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8924757

Citation

Fujimura, M, et al. "Effect of Capsaicin Inhalation On Methacholine Responsiveness in Normal Subjects." Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society, vol. 6, no. 1, 1996, pp. 45-8.
Fujimura M, Kamio Y, Hashimoto T, et al. Effect of capsaicin inhalation on methacholine responsiveness in normal subjects. Clin Auton Res. 1996;6(1):45-8.
Fujimura, M., Kamio, Y., Hashimoto, T., & Matsuda, T. (1996). Effect of capsaicin inhalation on methacholine responsiveness in normal subjects. Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society, 6(1), 45-8.
Fujimura M, et al. Effect of Capsaicin Inhalation On Methacholine Responsiveness in Normal Subjects. Clin Auton Res. 1996;6(1):45-8. PubMed PMID: 8924757.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of capsaicin inhalation on methacholine responsiveness in normal subjects. AU - Fujimura,M, AU - Kamio,Y, AU - Hashimoto,T, AU - Matsuda,T, PY - 1996/2/1/pubmed PY - 1996/2/1/medline PY - 1996/2/1/entrez SP - 45 EP - 8 JF - Clinical autonomic research : official journal of the Clinical Autonomic Research Society JO - Clin. Auton. Res. VL - 6 IS - 1 N2 - It has been reported that capsaicin stimulates bronchial C-fibers to release neuropeptides and enhances bronchial responsiveness in animal studies. This study was conducted to examine the effect of inhaled capsaicin on bronchial responsiveness in humans. A provocative concentration of methacholine producing a 20% fall in forced expiratory volume in one second (PC20-FEV1) was measured before and one hour after, one minute inhalation of 15.6 microM capsaicin solution (capsaicin day) or saline (saline day) in seven normal subjects whose PC20-FEV1 values were 40 mg/ml or less. Geometric mean value of PC20-FEV1 measured one hour after saline inhalation following pretreatment methacholine challenge was 89.3 (GSEM, 1.69) mg/ml which was significantly (p = 0.018) greater than that of the pre-treatment methacholine challenge [19.1 (GSEM, 1.37) mg/ml] on a saline day. However, PC20-FEV1 was not different before and one hour after inhalation of capsaicin [18.1 (GSEM, 1.40) and 23.1 (GSEM, 1.80) mg/ml] on a capsaicin day. The PC20-FEV1 value of the post-treatment methacholine test was significantly (p = 0.0277) lower after capsaicin inhalation than after saline inhalation while the value of pre-treatment methacholine provocation was not different between capsaicin and saline days. Change of the post-treatment PC20-FEV1 from the pre-treatment value shown as doubling concentrations was 0.35 +/- 0.60 on a capsaicin day which was significantly lower than that (2.23 +/- 0.47) on a saline day. These results confirm the decreased responses to repeated inhalation of methacholine (methacholine tachyphylaxis) in normal subjects and indicate that capsaicin inhalation reduces the methacholine tachyphylaxis. SN - 0959-9851 UR - https://www.unboundmedicine.com/medline/citation/8924757/Effect_of_capsaicin_inhalation_on_methacholine_responsiveness_in_normal_subjects_ DB - PRIME DP - Unbound Medicine ER -