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Invasion of murine intestinal M cells by Salmonella typhimurium inv mutants severely deficient for invasion of cultured cells.
Infect Immun. 1996 Oct; 64(10):4363-8.II

Abstract

We have examined the role of the Salmonella typhimurium inv locus in invasion of the murine intestine. Previous studies have demonstrated that M cells within the lymphoid-follicle-associated epithelia are the primary site of intestinal invasion by S. typhimurium. In this study, we show that mutants possessing defects in one of two inv genes, invA or invG, which render them severely deficient for invasion of polarized epithelial MDCK cells, retain their ability to actively invade mouse Peyer's patch M cells. The interaction of these mutants with M cells was associated with apical membrane remodelling resembling that induced by wild-type strains. These data demonstrate that Salmonella invasion in vivo can proceed via mechanisms other than those previously defined in cultured cells.

Authors+Show Affiliations

Department of Physiological Sciences, Medical School, University of Newcastle upon Tyne, United Kingdom.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8926113

Citation

Clark, M A., et al. "Invasion of Murine Intestinal M Cells By Salmonella Typhimurium Inv Mutants Severely Deficient for Invasion of Cultured Cells." Infection and Immunity, vol. 64, no. 10, 1996, pp. 4363-8.
Clark MA, Reed KA, Lodge J, et al. Invasion of murine intestinal M cells by Salmonella typhimurium inv mutants severely deficient for invasion of cultured cells. Infect Immun. 1996;64(10):4363-8.
Clark, M. A., Reed, K. A., Lodge, J., Stephen, J., Hirst, B. H., & Jepson, M. A. (1996). Invasion of murine intestinal M cells by Salmonella typhimurium inv mutants severely deficient for invasion of cultured cells. Infection and Immunity, 64(10), 4363-8.
Clark MA, et al. Invasion of Murine Intestinal M Cells By Salmonella Typhimurium Inv Mutants Severely Deficient for Invasion of Cultured Cells. Infect Immun. 1996;64(10):4363-8. PubMed PMID: 8926113.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Invasion of murine intestinal M cells by Salmonella typhimurium inv mutants severely deficient for invasion of cultured cells. AU - Clark,M A, AU - Reed,K A, AU - Lodge,J, AU - Stephen,J, AU - Hirst,B H, AU - Jepson,M A, PY - 1996/10/1/pubmed PY - 1996/10/1/medline PY - 1996/10/1/entrez SP - 4363 EP - 8 JF - Infection and immunity JO - Infect Immun VL - 64 IS - 10 N2 - We have examined the role of the Salmonella typhimurium inv locus in invasion of the murine intestine. Previous studies have demonstrated that M cells within the lymphoid-follicle-associated epithelia are the primary site of intestinal invasion by S. typhimurium. In this study, we show that mutants possessing defects in one of two inv genes, invA or invG, which render them severely deficient for invasion of polarized epithelial MDCK cells, retain their ability to actively invade mouse Peyer's patch M cells. The interaction of these mutants with M cells was associated with apical membrane remodelling resembling that induced by wild-type strains. These data demonstrate that Salmonella invasion in vivo can proceed via mechanisms other than those previously defined in cultured cells. SN - 0019-9567 UR - https://www.unboundmedicine.com/medline/citation/8926113/Invasion_of_murine_intestinal_M_cells_by_Salmonella_typhimurium_inv_mutants_severely_deficient_for_invasion_of_cultured_cells_ L2 - https://journals.asm.org/doi/10.1128/iai.64.10.4363-4368.1996?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -