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Tubular adenoma of the breast: an immunohistochemical study of ten cases.
Pathol Res Pract. 1995 Dec; 191(12):1222-30.PR

Abstract

Ten cases of so-called "tubular" adenoma and six cases of fibroadenoma of the breast have been investigated with an immunohistochemical technique with the aim of providing both more details on their immunophenotype and of ascertaining the possible relationships between tubular adenoma and fibroadenoma. Smooth Muscle Actin, Cytokeratin 14, GFAP, S-100 Protein and Vimentin immunoreactivity have clearly demonstrated that cells with myoepithelial immunophenotype are one of the major cell components in breast adenomas. Epithelial Membrane Antigen (EMA), Human Milk Fat Globule II (HMFG II), Estrogen and Progesterone receptors have been detected in adluminal epithelial cells exclusively. Furthermore, Smooth Muscle Actin and Vimentin highlighted an abundant myofibroblastic component, intermingled with tubular structures in both tumor types. A low percentage (10-22%) of adluminal cells and of myofibroblasts showed Ki-67 immunoreactivity in tubular adenomas and in fibroadenomas, whereas only rare myoepithelial cells demonstrated Ki-67 positivity in both tumor types. These data seem to indicate that several cell components of both epithelial and mesenchymal origin (epithelial cells, myoepithelial cells, myofibroblasts) are involved in the genesis of tubular adenomas. The morphological and immunohistochemical features of tubular adenomas closely resemble, in some areas of the tumors, those of fibroadenoma. Therefore, they may represent histogenetically related neoplasms with exuberant ductular component in tubular adenomas and predominant stromal component in fibroadenoma.

Authors+Show Affiliations

Institute of Pathological Anatomy, University of Bari, Italy.No affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

8927570

Citation

Maiorano, E, and M Albrizio. "Tubular Adenoma of the Breast: an Immunohistochemical Study of Ten Cases." Pathology, Research and Practice, vol. 191, no. 12, 1995, pp. 1222-30.
Maiorano E, Albrizio M. Tubular adenoma of the breast: an immunohistochemical study of ten cases. Pathol Res Pract. 1995;191(12):1222-30.
Maiorano, E., & Albrizio, M. (1995). Tubular adenoma of the breast: an immunohistochemical study of ten cases. Pathology, Research and Practice, 191(12), 1222-30.
Maiorano E, Albrizio M. Tubular Adenoma of the Breast: an Immunohistochemical Study of Ten Cases. Pathol Res Pract. 1995;191(12):1222-30. PubMed PMID: 8927570.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Tubular adenoma of the breast: an immunohistochemical study of ten cases. AU - Maiorano,E, AU - Albrizio,M, PY - 1995/12/1/pubmed PY - 1995/12/1/medline PY - 1995/12/1/entrez SP - 1222 EP - 30 JF - Pathology, research and practice JO - Pathol. Res. Pract. VL - 191 IS - 12 N2 - Ten cases of so-called "tubular" adenoma and six cases of fibroadenoma of the breast have been investigated with an immunohistochemical technique with the aim of providing both more details on their immunophenotype and of ascertaining the possible relationships between tubular adenoma and fibroadenoma. Smooth Muscle Actin, Cytokeratin 14, GFAP, S-100 Protein and Vimentin immunoreactivity have clearly demonstrated that cells with myoepithelial immunophenotype are one of the major cell components in breast adenomas. Epithelial Membrane Antigen (EMA), Human Milk Fat Globule II (HMFG II), Estrogen and Progesterone receptors have been detected in adluminal epithelial cells exclusively. Furthermore, Smooth Muscle Actin and Vimentin highlighted an abundant myofibroblastic component, intermingled with tubular structures in both tumor types. A low percentage (10-22%) of adluminal cells and of myofibroblasts showed Ki-67 immunoreactivity in tubular adenomas and in fibroadenomas, whereas only rare myoepithelial cells demonstrated Ki-67 positivity in both tumor types. These data seem to indicate that several cell components of both epithelial and mesenchymal origin (epithelial cells, myoepithelial cells, myofibroblasts) are involved in the genesis of tubular adenomas. The morphological and immunohistochemical features of tubular adenomas closely resemble, in some areas of the tumors, those of fibroadenoma. Therefore, they may represent histogenetically related neoplasms with exuberant ductular component in tubular adenomas and predominant stromal component in fibroadenoma. SN - 0344-0338 UR - https://www.unboundmedicine.com/medline/citation/8927570/Tubular_adenoma_of_the_breast:_an_immunohistochemical_study_of_ten_cases_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0344-0338(11)81130-1 DB - PRIME DP - Unbound Medicine ER -