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[Homocysteine and methylmalonic acid. New tests--for what benefit?].
Tidsskr Nor Laegeforen. 1996 Sep 20; 116(22):2677-9.TN

Abstract

A serum cobalamin level lower than 250 pmol/l combined with high values of plasma homocysteine and serum methylmalonic acid confirms the diagnosis of vitamin B12 deficiency. A low serum and erythrocyte folate level and high plasma homocysteine confirm folate deficiency. If the cobalamin level is higher than 250 pmol/l no further tests are needed. In patients with neurologic or psychiatric disorders combined with elevated levels of homocysteine and methylmalonic acid, cobalamin deficiency is likely if these levels decrease during vitamin B12 therapy. The causes of elevated homocysteine levels are often obscure, and homocysteine should therefore not be used as a screening test.

Authors+Show Affiliations

Hematologisk seksjon, Haukeland Sykehus, Bergen.No affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

nor

PubMed ID

8928147

Citation

Berentsen, S, and I Talstad. "[Homocysteine and Methylmalonic Acid. New Tests--for what Benefit?]." Tidsskrift for Den Norske Laegeforening : Tidsskrift for Praktisk Medicin, Ny Raekke, vol. 116, no. 22, 1996, pp. 2677-9.
Berentsen S, Talstad I. [Homocysteine and methylmalonic acid. New tests--for what benefit?]. Tidsskr Nor Laegeforen. 1996;116(22):2677-9.
Berentsen, S., & Talstad, I. (1996). [Homocysteine and methylmalonic acid. New tests--for what benefit?]. Tidsskrift for Den Norske Laegeforening : Tidsskrift for Praktisk Medicin, Ny Raekke, 116(22), 2677-9.
Berentsen S, Talstad I. [Homocysteine and Methylmalonic Acid. New Tests--for what Benefit?]. Tidsskr Nor Laegeforen. 1996 Sep 20;116(22):2677-9. PubMed PMID: 8928147.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Homocysteine and methylmalonic acid. New tests--for what benefit?]. AU - Berentsen,S, AU - Talstad,I, PY - 1996/9/20/pubmed PY - 1996/9/20/medline PY - 1996/9/20/entrez SP - 2677 EP - 9 JF - Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke JO - Tidsskr Nor Laegeforen VL - 116 IS - 22 N2 - A serum cobalamin level lower than 250 pmol/l combined with high values of plasma homocysteine and serum methylmalonic acid confirms the diagnosis of vitamin B12 deficiency. A low serum and erythrocyte folate level and high plasma homocysteine confirm folate deficiency. If the cobalamin level is higher than 250 pmol/l no further tests are needed. In patients with neurologic or psychiatric disorders combined with elevated levels of homocysteine and methylmalonic acid, cobalamin deficiency is likely if these levels decrease during vitamin B12 therapy. The causes of elevated homocysteine levels are often obscure, and homocysteine should therefore not be used as a screening test. SN - 0029-2001 UR - https://www.unboundmedicine.com/medline/citation/8928147/[Homocysteine_and_methylmalonic_acid__New_tests__for_what_benefit]_ DB - PRIME DP - Unbound Medicine ER -