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Stability of ceftazidime sodium and teicoplanin sodium in a peritoneal dialysis solution.
Am J Health Syst Pharm 1996; 53(22):2731-4AJ

Abstract

The stability of ceftazidime sodium and teicoplanin sodium separately and in combination in a peritoneal dialysis (PD) solution was studied. PD solutions containing ceftazidime 100 micrograms/mL (as the sodium salt), teicoplanin 25 micrograms/mL (as the sodium salt), or ceftazidime 100 micrograms/mL plus teicoplanin 24 micrograms/mL were prepared in triplicate for each of two conditions: condition A, storage at 25 degrees C (room temperature) for 24 hours, then at 37 degrees C for eight hours; and condition B, storage for seven days at 4 degrees C, followed by 16 hours at 25 degrees C and 8 hours at 37 degrees C. The dialysis solution used was Dianeal PD-2 with 1.5% dextrose. Samples were removed at intervals and analyzed by stability-indicating high-performance liquid chromatography. Under condition A, ceftazidime sodium alone was stable for 24 hours at 25 degrees C but only 2 hours when then heated to 37 degrees C. Under condition B, ceftazidime sodium alone was stable throughout the observation period. Teicoplanin sodium alone was stable throughout the observation periods under both conditions. In combination, the drugs were stable if initially refrigerated and then brought to room temperature one week later, but were unstable when initially stored at 25 degrees C. No visual changes were noted, and pH did not vary substantially. Ceftazidime 100 micrograms/mL (as the sodium salt) and teicoplanin 25 micrograms/mL (as the sodium salt) combined in a PD solution were unstable when first kept at 25 degrees C before storage at 37 degrees C. The drugs in the combination remained stable when the solution was kept at 4 degrees C before storage at 37 degrees C.

Authors+Show Affiliations

College of Pharmacy, Medical University of South Carolina, Charleston 29425-2305, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8931816

Citation

Manduru, M, et al. "Stability of Ceftazidime Sodium and Teicoplanin Sodium in a Peritoneal Dialysis Solution." American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists, vol. 53, no. 22, 1996, pp. 2731-4.
Manduru M, Fariello A, White RL, et al. Stability of ceftazidime sodium and teicoplanin sodium in a peritoneal dialysis solution. Am J Health Syst Pharm. 1996;53(22):2731-4.
Manduru, M., Fariello, A., White, R. L., Fox, J. L., & Bosso, J. A. (1996). Stability of ceftazidime sodium and teicoplanin sodium in a peritoneal dialysis solution. American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists, 53(22), pp. 2731-4.
Manduru M, et al. Stability of Ceftazidime Sodium and Teicoplanin Sodium in a Peritoneal Dialysis Solution. Am J Health Syst Pharm. 1996 Nov 15;53(22):2731-4. PubMed PMID: 8931816.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Stability of ceftazidime sodium and teicoplanin sodium in a peritoneal dialysis solution. AU - Manduru,M, AU - Fariello,A, AU - White,R L, AU - Fox,J L, AU - Bosso,J A, PY - 1996/11/15/pubmed PY - 1996/11/15/medline PY - 1996/11/15/entrez SP - 2731 EP - 4 JF - American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists JO - Am J Health Syst Pharm VL - 53 IS - 22 N2 - The stability of ceftazidime sodium and teicoplanin sodium separately and in combination in a peritoneal dialysis (PD) solution was studied. PD solutions containing ceftazidime 100 micrograms/mL (as the sodium salt), teicoplanin 25 micrograms/mL (as the sodium salt), or ceftazidime 100 micrograms/mL plus teicoplanin 24 micrograms/mL were prepared in triplicate for each of two conditions: condition A, storage at 25 degrees C (room temperature) for 24 hours, then at 37 degrees C for eight hours; and condition B, storage for seven days at 4 degrees C, followed by 16 hours at 25 degrees C and 8 hours at 37 degrees C. The dialysis solution used was Dianeal PD-2 with 1.5% dextrose. Samples were removed at intervals and analyzed by stability-indicating high-performance liquid chromatography. Under condition A, ceftazidime sodium alone was stable for 24 hours at 25 degrees C but only 2 hours when then heated to 37 degrees C. Under condition B, ceftazidime sodium alone was stable throughout the observation period. Teicoplanin sodium alone was stable throughout the observation periods under both conditions. In combination, the drugs were stable if initially refrigerated and then brought to room temperature one week later, but were unstable when initially stored at 25 degrees C. No visual changes were noted, and pH did not vary substantially. Ceftazidime 100 micrograms/mL (as the sodium salt) and teicoplanin 25 micrograms/mL (as the sodium salt) combined in a PD solution were unstable when first kept at 25 degrees C before storage at 37 degrees C. The drugs in the combination remained stable when the solution was kept at 4 degrees C before storage at 37 degrees C. SN - 1079-2082 UR - https://www.unboundmedicine.com/medline/citation/8931816/Stability_of_ceftazidime_sodium_and_teicoplanin_sodium_in_a_peritoneal_dialysis_solution_ L2 - https://academic.oup.com/ajhp/article-lookup/doi/10.1093/ajhp/53.22.2731 DB - PRIME DP - Unbound Medicine ER -