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The effect of ether lipid 1-O-octadecyl-2-O-methoxy-rac-glycero-3-phosphocholine and its analogues platelet activating factor and carbamyl-platelet activating factor on the biosynthesis of interleukin-6 in human thymic epithelial cells cultivated in vitro.
Cytokine. 1996 Sep; 8(9):698-701.C

Abstract

The effect of ether lipid 1-O-Octadecyl-2-O-methoxy-rac-glycero-3-phosphocholine (ET-18-OCH3), platelet activating factor (PAF) and carbamyl activating factor (CPAF) on the release of IL-6 in human thymic epithelium cultivated in vitro was studied. ET-18-OCH3 significantly increased the release of IL-6, giving the greatest effect at the dose of 2 micrograms/ml. PAF had no effect. The non-metabolizable CPAF was less effective than ET-18-OCH3 and showed the greatest release of IL-6 at the dose of 1 microgram/ml. Ether lipid ET-18-OCH3 has a thymotrophic effect as has also been demonstrated by other results obtained in our previous work.

Authors+Show Affiliations

Institute of Human Physiology, Faculty of Medicine, University of Catania, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8932980

Citation

Cardile, V, et al. "The Effect of Ether Lipid 1-O-octadecyl-2-O-methoxy-rac-glycero-3-phosphocholine and Its Analogues Platelet Activating Factor and Carbamyl-platelet Activating Factor On the Biosynthesis of Interleukin-6 in Human Thymic Epithelial Cells Cultivated in Vitro." Cytokine, vol. 8, no. 9, 1996, pp. 698-701.
Cardile V, Mascarucci P, De Simoni MG, et al. The effect of ether lipid 1-O-octadecyl-2-O-methoxy-rac-glycero-3-phosphocholine and its analogues platelet activating factor and carbamyl-platelet activating factor on the biosynthesis of interleukin-6 in human thymic epithelial cells cultivated in vitro. Cytokine. 1996;8(9):698-701.
Cardile, V., Mascarucci, P., De Simoni, M. G., Jiang, X., & Bindoni, M. (1996). The effect of ether lipid 1-O-octadecyl-2-O-methoxy-rac-glycero-3-phosphocholine and its analogues platelet activating factor and carbamyl-platelet activating factor on the biosynthesis of interleukin-6 in human thymic epithelial cells cultivated in vitro. Cytokine, 8(9), 698-701.
Cardile V, et al. The Effect of Ether Lipid 1-O-octadecyl-2-O-methoxy-rac-glycero-3-phosphocholine and Its Analogues Platelet Activating Factor and Carbamyl-platelet Activating Factor On the Biosynthesis of Interleukin-6 in Human Thymic Epithelial Cells Cultivated in Vitro. Cytokine. 1996;8(9):698-701. PubMed PMID: 8932980.
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TY - JOUR T1 - The effect of ether lipid 1-O-octadecyl-2-O-methoxy-rac-glycero-3-phosphocholine and its analogues platelet activating factor and carbamyl-platelet activating factor on the biosynthesis of interleukin-6 in human thymic epithelial cells cultivated in vitro. AU - Cardile,V, AU - Mascarucci,P, AU - De Simoni,M G, AU - Jiang,X, AU - Bindoni,M, PY - 1996/9/1/pubmed PY - 1996/9/1/medline PY - 1996/9/1/entrez SP - 698 EP - 701 JF - Cytokine JO - Cytokine VL - 8 IS - 9 N2 - The effect of ether lipid 1-O-Octadecyl-2-O-methoxy-rac-glycero-3-phosphocholine (ET-18-OCH3), platelet activating factor (PAF) and carbamyl activating factor (CPAF) on the release of IL-6 in human thymic epithelium cultivated in vitro was studied. ET-18-OCH3 significantly increased the release of IL-6, giving the greatest effect at the dose of 2 micrograms/ml. PAF had no effect. The non-metabolizable CPAF was less effective than ET-18-OCH3 and showed the greatest release of IL-6 at the dose of 1 microgram/ml. Ether lipid ET-18-OCH3 has a thymotrophic effect as has also been demonstrated by other results obtained in our previous work. SN - 1043-4666 UR - https://www.unboundmedicine.com/medline/citation/8932980/The_effect_of_ether_lipid_1_O_octadecyl_2_O_methoxy_rac_glycero_3_phosphocholine_and_its_analogues_platelet_activating_factor_and_carbamyl_platelet_activating_factor_on_the_biosynthesis_of_interleukin_6_in_human_thymic_epithelial_cells_cultivated_in_vitro_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1043-4666(96)90092-7 DB - PRIME DP - Unbound Medicine ER -