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Fish diet, fish oil and docosahexaenoic acid rich oil lower fasting and postprandial plasma lipid levels.
Eur J Clin Nutr. 1996 Nov; 50(11):765-71.EJ

Abstract

OBJECTIVE

The present study was carried out to clarify the effects of fish diet, fish oil and docosahexaenoic acid (DHA) rich oil on fasting and postprandial lipid levels in healthy male students.

DESIGN

The study was a randomized single-blind study with a control and three study groups.

SETTING

The study was carried out in the Departments of Physiology and Clinical Nutrition of University of Kuopio.

SUBJECTS

Healthy male volunteers were recruited for the study from the university student population. Fifty-nine subjects entered and 55 completed the study.

INTERVENTIONS

For 15 weeks the subjects in the fish diet group ate 4.3 +/- 0.5 fish containing meals per week and those in the fish oil and DHA-oil groups ate 4 g oil per day. Fish diet provided 0.38 +/- 0.04 g eicosapentaenoic acid (EPA) and 0.67 +/- 0.09 g DHA, fish oil 1.33 g EPA and 0.95 g DHA and DHA-oil (EPA-free) 1.68 g DHA per day.

RESULTS

Fasting plasma triglyceride levels decreased in all test groups in 14 weeks when compared to the control group (P < 0.05). Total plasma cholesterol levels did not change but the HDL2/HDL3-cholesterol ratio increased in all test groups by over 50% (P < 0.05). The postprandial total and chylomicron triglyceride responses, measured as areas under the response curve, were lowered in 15 weeks by the fish diet and fish oil (P < 0.05), the same tendency (P < 0.1) being seen in DHA-oil group.

CONCLUSIONS

These results show that both fasting and postprandial triglyceride concentrations can be decreased with moderate intakes of long-chain n-3 fatty acids either from a fish diet or fish oil and that also pure DHA has a hypotriglyceridemic effect.

Authors+Show Affiliations

Agren JJ
Department of Physiology, University of Kuopio, Finland.
Hänninen O
No affiliation info available
Julkunen A
No affiliation info available
Fogelholm L
No affiliation info available
Vidgren H
No affiliation info available
Schwab U
No affiliation info available
Pynnönen O
No affiliation info available
Uusitupa M
No affiliation info available

MeSH

AdultAnimalsCholesterolDietary FatsDocosahexaenoic AcidsFastingFish OilsFishesHumansMalePostprandial PeriodSingle-Blind MethodTriglycerides

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8933125

Citation

Agren, J J., et al. "Fish Diet, Fish Oil and Docosahexaenoic Acid Rich Oil Lower Fasting and Postprandial Plasma Lipid Levels." European Journal of Clinical Nutrition, vol. 50, no. 11, 1996, pp. 765-71.
Agren JJ, Hänninen O, Julkunen A, et al. Fish diet, fish oil and docosahexaenoic acid rich oil lower fasting and postprandial plasma lipid levels. Eur J Clin Nutr. 1996;50(11):765-71.
Agren, J. J., Hänninen, O., Julkunen, A., Fogelholm, L., Vidgren, H., Schwab, U., Pynnönen, O., & Uusitupa, M. (1996). Fish diet, fish oil and docosahexaenoic acid rich oil lower fasting and postprandial plasma lipid levels. European Journal of Clinical Nutrition, 50(11), 765-71.
Agren JJ, et al. Fish Diet, Fish Oil and Docosahexaenoic Acid Rich Oil Lower Fasting and Postprandial Plasma Lipid Levels. Eur J Clin Nutr. 1996;50(11):765-71. PubMed PMID: 8933125.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Fish diet, fish oil and docosahexaenoic acid rich oil lower fasting and postprandial plasma lipid levels. AU - Agren,J J, AU - Hänninen,O, AU - Julkunen,A, AU - Fogelholm,L, AU - Vidgren,H, AU - Schwab,U, AU - Pynnönen,O, AU - Uusitupa,M, PY - 1996/11/1/pubmed PY - 1996/11/1/medline PY - 1996/11/1/entrez SP - 765 EP - 71 JF - European journal of clinical nutrition JO - Eur J Clin Nutr VL - 50 IS - 11 N2 - OBJECTIVE: The present study was carried out to clarify the effects of fish diet, fish oil and docosahexaenoic acid (DHA) rich oil on fasting and postprandial lipid levels in healthy male students. DESIGN: The study was a randomized single-blind study with a control and three study groups. SETTING: The study was carried out in the Departments of Physiology and Clinical Nutrition of University of Kuopio. SUBJECTS: Healthy male volunteers were recruited for the study from the university student population. Fifty-nine subjects entered and 55 completed the study. INTERVENTIONS: For 15 weeks the subjects in the fish diet group ate 4.3 +/- 0.5 fish containing meals per week and those in the fish oil and DHA-oil groups ate 4 g oil per day. Fish diet provided 0.38 +/- 0.04 g eicosapentaenoic acid (EPA) and 0.67 +/- 0.09 g DHA, fish oil 1.33 g EPA and 0.95 g DHA and DHA-oil (EPA-free) 1.68 g DHA per day. RESULTS: Fasting plasma triglyceride levels decreased in all test groups in 14 weeks when compared to the control group (P < 0.05). Total plasma cholesterol levels did not change but the HDL2/HDL3-cholesterol ratio increased in all test groups by over 50% (P < 0.05). The postprandial total and chylomicron triglyceride responses, measured as areas under the response curve, were lowered in 15 weeks by the fish diet and fish oil (P < 0.05), the same tendency (P < 0.1) being seen in DHA-oil group. CONCLUSIONS: These results show that both fasting and postprandial triglyceride concentrations can be decreased with moderate intakes of long-chain n-3 fatty acids either from a fish diet or fish oil and that also pure DHA has a hypotriglyceridemic effect. SN - 0954-3007 UR - https://www.unboundmedicine.com/medline/citation/8933125/Fish_diet_fish_oil_and_docosahexaenoic_acid_rich_oil_lower_fasting_and_postprandial_plasma_lipid_levels_ L2 - https://medlineplus.gov/cholesterollevelswhatyouneedtoknow.html DB - PRIME DP - Unbound Medicine ER -