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Hippocampus and learning: possible role of histamine receptors.
Medicina (B Aires). 1996; 56(2):155-60.M

Abstract

The effect of local administration of histamine and its receptor antagonists into the hippocampus on the learning process of an active avoidance response was studied. The task that the animals had to learn consisted in avoiding an electric shock on their feet after a conditioning ultrasonic 40 kHz tone was on. Latency time was defined as the time in sec rats took to avoid or escape the electric shock: % CAR was defined as the cummulative positive responses during learning session. All rats were implanted into the ventral hippocampus with guide cannulae. On the day of the experiment, rats were microinjected through the guide cannulae with 1 microliter of saline solution containing 67.5 nmol of ranitidine or pyrilamine alone or in combination with 45 nmol of histamine. All groups were subjected to two sessions of learning. Results show that treatment with histamine was effective to block the adquisition of the response, since animals showed a learning curve significantly inferior to that of the controls. Ranitidine treatment was not able to block the histamine effect. Pyrilamine treatment, instead, was effective to block the inhibitory action of histamine on learning. Results suggest that histamine in hippocampus may be exerting a modulatory control on retrieval processes of memory.

Authors+Show Affiliations

Cátedra de Física Biológica, Universidad Nacional de Cuyo, Mendoza, Argentina.No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8935568

Citation

Alvarez, E O., and A M. Banzan. "Hippocampus and Learning: Possible Role of Histamine Receptors." Medicina, vol. 56, no. 2, 1996, pp. 155-60.
Alvarez EO, Banzan AM. Hippocampus and learning: possible role of histamine receptors. Medicina (B Aires). 1996;56(2):155-60.
Alvarez, E. O., & Banzan, A. M. (1996). Hippocampus and learning: possible role of histamine receptors. Medicina, 56(2), 155-60.
Alvarez EO, Banzan AM. Hippocampus and Learning: Possible Role of Histamine Receptors. Medicina (B Aires). 1996;56(2):155-60. PubMed PMID: 8935568.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hippocampus and learning: possible role of histamine receptors. AU - Alvarez,E O, AU - Banzan,A M, PY - 1996/1/1/pubmed PY - 1996/1/1/medline PY - 1996/1/1/entrez SP - 155 EP - 60 JF - Medicina JO - Medicina (B Aires) VL - 56 IS - 2 N2 - The effect of local administration of histamine and its receptor antagonists into the hippocampus on the learning process of an active avoidance response was studied. The task that the animals had to learn consisted in avoiding an electric shock on their feet after a conditioning ultrasonic 40 kHz tone was on. Latency time was defined as the time in sec rats took to avoid or escape the electric shock: % CAR was defined as the cummulative positive responses during learning session. All rats were implanted into the ventral hippocampus with guide cannulae. On the day of the experiment, rats were microinjected through the guide cannulae with 1 microliter of saline solution containing 67.5 nmol of ranitidine or pyrilamine alone or in combination with 45 nmol of histamine. All groups were subjected to two sessions of learning. Results show that treatment with histamine was effective to block the adquisition of the response, since animals showed a learning curve significantly inferior to that of the controls. Ranitidine treatment was not able to block the histamine effect. Pyrilamine treatment, instead, was effective to block the inhibitory action of histamine on learning. Results suggest that histamine in hippocampus may be exerting a modulatory control on retrieval processes of memory. SN - 0025-7680 UR - https://www.unboundmedicine.com/medline/citation/8935568/Hippocampus_and_learning:_possible_role_of_histamine_receptors_ L2 - https://medlineplus.gov/memory.html DB - PRIME DP - Unbound Medicine ER -