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Early bronchoscopic diagnosis of concomitant tuberculosis and Pneumocystis carinii pneumonia in patients with human immunodeficiency virus infection.
J Assoc Acad Minor Phys. 1996; 7(4):99-103.JA

Abstract

Pulmonary infections, including mixed infections, are common in patients with human immunodeficiency virus (HIV), and a specific diagnosis is desirable to direct therapy. In a retrospective study of patients suspected of having Pneumocystis carinii pneumonia, we examined the usefulness of fiberoptic bronchoscopy in the immediate diagnosis of tuberculosis. In 267 patients, pneumocystis pneumonia was diagnosed in 115 (43%), of whom 5 (4%) also had concomitant tuberculosis. Bronchoalveolar lavage gave an immediate diagnosis of tuberculosis by positive acid-fast bacilli stain in 3 patients, while the transbronchial biopsy was suggestive in a fourth. Four of these patients developed respiratory failure, and 2 died. In patients with pneumocystis pneumonia, respiratory failure was significantly more common in those with tuberculosis (P = .0077). In 156 (58%) of the 267 cases, bronchoalveolar lavage was negative for pneumocystis pneumonia, while tuberculosis was diagnosed in 14 (9%), and an immediate diagnosis was made in 10 (71%). In a series of HIV-infected patients suspected mainly of having pneumocystis pneumonia, tuberculosis was found instead in 19 (7%), and both diseases were present in 5 (2%). Bronchoscopy provided an early diagnosis of tuberculosis in 63%. Patients with concomitant pneumocystis pneumonia and tuberculosis had a high rate of respiratory failure.

Authors+Show Affiliations

Albino JA
National Tuberculosis Center, LMDNJ-New Jersey Medical School, Newark, 07103, USA.
Shapiro JM
No affiliation info available

MeSH

AIDS-Related Opportunistic InfectionsAdultBronchoscopyFemaleHumansMaleMiddle AgedPneumonia, PneumocystisRetrospective StudiesSensitivity and SpecificityTime FactorsTuberculosis

Pub Type(s)

Journal Article

Language

eng

PubMed ID

8936936

Citation

Albino, J A., and J M. Shapiro. "Early Bronchoscopic Diagnosis of Concomitant Tuberculosis and Pneumocystis Carinii Pneumonia in Patients With Human Immunodeficiency Virus Infection." Journal of the Association for Academic Minority Physicians : the Official Publication of the Association for Academic Minority Physicians, vol. 7, no. 4, 1996, pp. 99-103.
Albino JA, Shapiro JM. Early bronchoscopic diagnosis of concomitant tuberculosis and Pneumocystis carinii pneumonia in patients with human immunodeficiency virus infection. J Assoc Acad Minor Phys. 1996;7(4):99-103.
Albino, J. A., & Shapiro, J. M. (1996). Early bronchoscopic diagnosis of concomitant tuberculosis and Pneumocystis carinii pneumonia in patients with human immunodeficiency virus infection. Journal of the Association for Academic Minority Physicians : the Official Publication of the Association for Academic Minority Physicians, 7(4), 99-103.
Albino JA, Shapiro JM. Early Bronchoscopic Diagnosis of Concomitant Tuberculosis and Pneumocystis Carinii Pneumonia in Patients With Human Immunodeficiency Virus Infection. J Assoc Acad Minor Phys. 1996;7(4):99-103. PubMed PMID: 8936936.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Early bronchoscopic diagnosis of concomitant tuberculosis and Pneumocystis carinii pneumonia in patients with human immunodeficiency virus infection. AU - Albino,J A, AU - Shapiro,J M, PY - 1996/1/1/pubmed PY - 1996/1/1/medline PY - 1996/1/1/entrez SP - 99 EP - 103 JF - Journal of the Association for Academic Minority Physicians : the official publication of the Association for Academic Minority Physicians JO - J Assoc Acad Minor Phys VL - 7 IS - 4 N2 - Pulmonary infections, including mixed infections, are common in patients with human immunodeficiency virus (HIV), and a specific diagnosis is desirable to direct therapy. In a retrospective study of patients suspected of having Pneumocystis carinii pneumonia, we examined the usefulness of fiberoptic bronchoscopy in the immediate diagnosis of tuberculosis. In 267 patients, pneumocystis pneumonia was diagnosed in 115 (43%), of whom 5 (4%) also had concomitant tuberculosis. Bronchoalveolar lavage gave an immediate diagnosis of tuberculosis by positive acid-fast bacilli stain in 3 patients, while the transbronchial biopsy was suggestive in a fourth. Four of these patients developed respiratory failure, and 2 died. In patients with pneumocystis pneumonia, respiratory failure was significantly more common in those with tuberculosis (P = .0077). In 156 (58%) of the 267 cases, bronchoalveolar lavage was negative for pneumocystis pneumonia, while tuberculosis was diagnosed in 14 (9%), and an immediate diagnosis was made in 10 (71%). In a series of HIV-infected patients suspected mainly of having pneumocystis pneumonia, tuberculosis was found instead in 19 (7%), and both diseases were present in 5 (2%). Bronchoscopy provided an early diagnosis of tuberculosis in 63%. Patients with concomitant pneumocystis pneumonia and tuberculosis had a high rate of respiratory failure. SN - 1048-9886 UR - https://www.unboundmedicine.com/medline/citation/8936936/Early_bronchoscopic_diagnosis_of_concomitant_tuberculosis_and_Pneumocystis_carinii_pneumonia_in_patients_with_human_immunodeficiency_virus_infection_ L2 - http://www.diseaseinfosearch.org/result/7252 DB - PRIME DP - Unbound Medicine ER -