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The IgA subclass distributions of endomysium and gliadin antibodies in human sera are different.
Clin Chim Acta. 1996 Nov 29; 255(2):145-52.CC

Abstract

Subclass distributions of total IgA, IgA gliadin antibodies and IgA endomysium antibodies were investigated in 26 sera of patients with coeliac disease or dermatitis herpetiformis by means of enzyme immunoassay and fluorescence microscopy. Eight-point-three percent of total IgA belonged to the IgA2 subclass. The fraction of IgA2 gliadin antibodies amounted to 30.6% of IgA gliadin antibodies and was significantly different from the proportion of total IgA2. The relative percentage of IgA2 endomysium antibodies was very close to that of total IgA2 in serum (6.2%) and significantly lower than that of IgA2 gliadin antibodies. The results suggest an intestinal origin of gliadin antibodies. Different subclass distribution of IgA endomysium antibodies may be due to extraintestinal production or to the different nature of the endomysium antigen eliciting a more prominent IgA1 response than gliadin.

Authors+Show Affiliations

Institute of Clinical Chemistry and Pathobiochemistry of the University, Leipzig, Germany.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8937757

Citation

Osman, A A., et al. "The IgA Subclass Distributions of Endomysium and Gliadin Antibodies in Human Sera Are Different." Clinica Chimica Acta; International Journal of Clinical Chemistry, vol. 255, no. 2, 1996, pp. 145-52.
Osman AA, Richter T, Stern M, et al. The IgA subclass distributions of endomysium and gliadin antibodies in human sera are different. Clin Chim Acta. 1996;255(2):145-52.
Osman, A. A., Richter, T., Stern, M., & Mothes, T. (1996). The IgA subclass distributions of endomysium and gliadin antibodies in human sera are different. Clinica Chimica Acta; International Journal of Clinical Chemistry, 255(2), 145-52.
Osman AA, et al. The IgA Subclass Distributions of Endomysium and Gliadin Antibodies in Human Sera Are Different. Clin Chim Acta. 1996 Nov 29;255(2):145-52. PubMed PMID: 8937757.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The IgA subclass distributions of endomysium and gliadin antibodies in human sera are different. AU - Osman,A A, AU - Richter,T, AU - Stern,M, AU - Mothes,T, PY - 1996/11/29/pubmed PY - 1996/11/29/medline PY - 1996/11/29/entrez SP - 145 EP - 52 JF - Clinica chimica acta; international journal of clinical chemistry JO - Clin Chim Acta VL - 255 IS - 2 N2 - Subclass distributions of total IgA, IgA gliadin antibodies and IgA endomysium antibodies were investigated in 26 sera of patients with coeliac disease or dermatitis herpetiformis by means of enzyme immunoassay and fluorescence microscopy. Eight-point-three percent of total IgA belonged to the IgA2 subclass. The fraction of IgA2 gliadin antibodies amounted to 30.6% of IgA gliadin antibodies and was significantly different from the proportion of total IgA2. The relative percentage of IgA2 endomysium antibodies was very close to that of total IgA2 in serum (6.2%) and significantly lower than that of IgA2 gliadin antibodies. The results suggest an intestinal origin of gliadin antibodies. Different subclass distribution of IgA endomysium antibodies may be due to extraintestinal production or to the different nature of the endomysium antigen eliciting a more prominent IgA1 response than gliadin. SN - 0009-8981 UR - https://www.unboundmedicine.com/medline/citation/8937757/The_IgA_subclass_distributions_of_endomysium_and_gliadin_antibodies_in_human_sera_are_different_ L2 - https://linkinghub.elsevier.com/retrieve/pii/0009-8981(96)06401-7 DB - PRIME DP - Unbound Medicine ER -