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Gastroesophageal reflux in obese patients is not reduced by weight reduction.

Abstract

BACKGROUND

The present study tested the hypothesis that weight reduction improves the subjective and objective manifestations of gastroesophageal reflux.

METHODS

Twenty obese patients with gastroesophageal reflux as shown by 24-h pH measurement and with symptoms requiring daily medication were studied. The patients were randomized into a group (A) treated with very low-caloric diet (VLCD) and a control group (B). Objective measurements were repeated after 6 months. Group B was then treated with VLCD and reexamined.

RESULTS

Patients in group A lost 10.8 +/- 1.4 kg whereas group B gained 0.6 +/- 0.7 kg (P < 0.001). There was no reduction in reflux according to pH measurement. Furthermore, there were no significant changes in reflux symptoms. After VLCD treatment, group B lost 9.7 +/- 1.6 kg, but reflux indicators remained unchanged. All patients except one in group B remained dependent on daily anti-reflux medication.

CONCLUSION

Weight reduction does not improve the subjective or objective manifestations of reflux.

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Authors+Show Affiliations

,

Dept. of Surgery, Ersta Hospital, Stockholm, Sweden.

, ,

Source

MeSH

Body Mass Index
Diet, Reducing
Esophagogastric Junction
Female
Follow-Up Studies
Gastroesophageal Reflux
Humans
Hydrogen-Ion Concentration
Male
Manometry
Middle Aged
Obesity
Time Factors
Weight Loss

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8938895

Citation

Kjellin, A, et al. "Gastroesophageal Reflux in Obese Patients Is Not Reduced By Weight Reduction." Scandinavian Journal of Gastroenterology, vol. 31, no. 11, 1996, pp. 1047-51.
Kjellin A, Ramel S, Rössner S, et al. Gastroesophageal reflux in obese patients is not reduced by weight reduction. Scand J Gastroenterol. 1996;31(11):1047-51.
Kjellin, A., Ramel, S., Rössner, S., & Thor, K. (1996). Gastroesophageal reflux in obese patients is not reduced by weight reduction. Scandinavian Journal of Gastroenterology, 31(11), pp. 1047-51.
Kjellin A, et al. Gastroesophageal Reflux in Obese Patients Is Not Reduced By Weight Reduction. Scand J Gastroenterol. 1996;31(11):1047-51. PubMed PMID: 8938895.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Gastroesophageal reflux in obese patients is not reduced by weight reduction. AU - Kjellin,A, AU - Ramel,S, AU - Rössner,S, AU - Thor,K, PY - 1996/11/1/pubmed PY - 1996/11/1/medline PY - 1996/11/1/entrez SP - 1047 EP - 51 JF - Scandinavian journal of gastroenterology JO - Scand. J. Gastroenterol. VL - 31 IS - 11 N2 - BACKGROUND: The present study tested the hypothesis that weight reduction improves the subjective and objective manifestations of gastroesophageal reflux. METHODS: Twenty obese patients with gastroesophageal reflux as shown by 24-h pH measurement and with symptoms requiring daily medication were studied. The patients were randomized into a group (A) treated with very low-caloric diet (VLCD) and a control group (B). Objective measurements were repeated after 6 months. Group B was then treated with VLCD and reexamined. RESULTS: Patients in group A lost 10.8 +/- 1.4 kg whereas group B gained 0.6 +/- 0.7 kg (P < 0.001). There was no reduction in reflux according to pH measurement. Furthermore, there were no significant changes in reflux symptoms. After VLCD treatment, group B lost 9.7 +/- 1.6 kg, but reflux indicators remained unchanged. All patients except one in group B remained dependent on daily anti-reflux medication. CONCLUSION: Weight reduction does not improve the subjective or objective manifestations of reflux. SN - 0036-5521 UR - https://www.unboundmedicine.com/medline/citation/8938895/Gastroesophageal_reflux_in_obese_patients_is_not_reduced_by_weight_reduction_ L2 - http://www.diseaseinfosearch.org/result/2996 DB - PRIME DP - Unbound Medicine ER -