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A nested case-control study on alcohol drinking, tobacco smoking, and cancer.
Cancer Detect Prev. 1996; 20(6):557-65.CD

Abstract

A nested case-control study was conducted to investigate the effect of alcohol consumption and tobacco smoking on cancers of various sites. The study population was based on 887 cases and 1774 controls, selected from a cohort of 17,200 male participants of a gastric mass survey in 1984, who were followed up for 9 years by the Chiba Cancer Registry, Japan. The odds ratio (OR) of colon cancer was significantly elevated in alcohol drinkers of one cup of sake-equivalent (27 ml ethanol) per day (OR = 3.5), and three cups of sake-equivalents per day (OR = 3.2) compared with nondrinkers, but its dose-response was not clear since two cups of sake-equivalents per day had an OR of 1.9, which was nonsignificant. Cancer risk elevation was especially predominant in the proximal colon, again showing no dose-response: OR = 30.7 for one cup of sake-equivalent per day, OR = 12.4 for two or more cups per day. Lung cancer showed a dose-response relationship with alcohol consumption, independent of tobacco smoking. A synergistic effect of alcohol intake and tobacco smoking was observed for upper aerodigestive tract and bladder cancer. Both alcohol drinking and tobacco smoking were found not to be associated with stomach cancer.

Authors+Show Affiliations

Division of Epidemiology, Chiba Cancer Center Research Institute, Japan.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8939341

Citation

Murata, M, et al. "A Nested Case-control Study On Alcohol Drinking, Tobacco Smoking, and Cancer." Cancer Detection and Prevention, vol. 20, no. 6, 1996, pp. 557-65.
Murata M, Takayama K, Choi BC, et al. A nested case-control study on alcohol drinking, tobacco smoking, and cancer. Cancer Detect Prev. 1996;20(6):557-65.
Murata, M., Takayama, K., Choi, B. C., & Pak, A. W. (1996). A nested case-control study on alcohol drinking, tobacco smoking, and cancer. Cancer Detection and Prevention, 20(6), 557-65.
Murata M, et al. A Nested Case-control Study On Alcohol Drinking, Tobacco Smoking, and Cancer. Cancer Detect Prev. 1996;20(6):557-65. PubMed PMID: 8939341.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A nested case-control study on alcohol drinking, tobacco smoking, and cancer. AU - Murata,M, AU - Takayama,K, AU - Choi,B C, AU - Pak,A W, PY - 1996/1/1/pubmed PY - 1996/1/1/medline PY - 1996/1/1/entrez SP - 557 EP - 65 JF - Cancer detection and prevention JO - Cancer Detect. Prev. VL - 20 IS - 6 N2 - A nested case-control study was conducted to investigate the effect of alcohol consumption and tobacco smoking on cancers of various sites. The study population was based on 887 cases and 1774 controls, selected from a cohort of 17,200 male participants of a gastric mass survey in 1984, who were followed up for 9 years by the Chiba Cancer Registry, Japan. The odds ratio (OR) of colon cancer was significantly elevated in alcohol drinkers of one cup of sake-equivalent (27 ml ethanol) per day (OR = 3.5), and three cups of sake-equivalents per day (OR = 3.2) compared with nondrinkers, but its dose-response was not clear since two cups of sake-equivalents per day had an OR of 1.9, which was nonsignificant. Cancer risk elevation was especially predominant in the proximal colon, again showing no dose-response: OR = 30.7 for one cup of sake-equivalent per day, OR = 12.4 for two or more cups per day. Lung cancer showed a dose-response relationship with alcohol consumption, independent of tobacco smoking. A synergistic effect of alcohol intake and tobacco smoking was observed for upper aerodigestive tract and bladder cancer. Both alcohol drinking and tobacco smoking were found not to be associated with stomach cancer. SN - 0361-090X UR - https://www.unboundmedicine.com/medline/citation/8939341/A_nested_case_control_study_on_alcohol_drinking_tobacco_smoking_and_cancer_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=8939341.ui DB - PRIME DP - Unbound Medicine ER -