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Plasma lipid oxidation and susceptibility of low-density lipoproteins to oxidation in male patients with stable coronary artery disease.
Clin Biochem. 1996 Dec; 29(6):573-9.CB

Abstract

OBJECTIVES

Oxidative modifications of low-density lipoproteins (LDL) are considered to be important in the pathogenesis of atherosclerosis. However, the data on the association between LDL oxidation and severity of clinical manifestations of coronary artery disease (CAD) are contradictory. Previous reports were concerned mostly with unstable angina patients. The present study was undertaken to evaluate plasma lipid oxidation status in patients with stable CAD.

DESIGN AND METHODS

37 male patients with angiographically confirmed CAD (asymptomatic or suffering from stable angina pectoris) and 32 control subjects were used in the study. Plasma levels of vitamin E and products of lipid peroxidation, as well as parameters of the test for oxidizability of LDL in vitro were measured.

RESULTS

We did not find differences between 2 groups of individuals regarding the levels of products of lipid peroxidation, vitamin E levels, lag time, maximal rate of oxidation, and total amount of conjugated dienes in the test for oxidizability of LDL.

CONCLUSION

The results of our study challenge, but do not disprove, the oxidative hypothesis of atherosclerosis. Real atherosclerotic modifications of plasma LDL occur apparently in the vascular wall after trapping of LDL by the interstitial matrix. The rise in oxidative parameters in unstable angina reported in the literature may not be the cause of the disease but, rather, the consequence of the multiple brief episodes of ischemia-reperfusion.

Authors+Show Affiliations

Department of Biochemistry and Coronary Care Unit, Lady Davis Carmel Hospital, Haifa, Israel.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

8939406

Citation

Karmansky, I, et al. "Plasma Lipid Oxidation and Susceptibility of Low-density Lipoproteins to Oxidation in Male Patients With Stable Coronary Artery Disease." Clinical Biochemistry, vol. 29, no. 6, 1996, pp. 573-9.
Karmansky I, Shnaider H, Palant A, et al. Plasma lipid oxidation and susceptibility of low-density lipoproteins to oxidation in male patients with stable coronary artery disease. Clin Biochem. 1996;29(6):573-9.
Karmansky, I., Shnaider, H., Palant, A., & Gruener, N. (1996). Plasma lipid oxidation and susceptibility of low-density lipoproteins to oxidation in male patients with stable coronary artery disease. Clinical Biochemistry, 29(6), 573-9.
Karmansky I, et al. Plasma Lipid Oxidation and Susceptibility of Low-density Lipoproteins to Oxidation in Male Patients With Stable Coronary Artery Disease. Clin Biochem. 1996;29(6):573-9. PubMed PMID: 8939406.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Plasma lipid oxidation and susceptibility of low-density lipoproteins to oxidation in male patients with stable coronary artery disease. AU - Karmansky,I, AU - Shnaider,H, AU - Palant,A, AU - Gruener,N, PY - 1996/12/1/pubmed PY - 1996/12/1/medline PY - 1996/12/1/entrez SP - 573 EP - 9 JF - Clinical biochemistry JO - Clin Biochem VL - 29 IS - 6 N2 - OBJECTIVES: Oxidative modifications of low-density lipoproteins (LDL) are considered to be important in the pathogenesis of atherosclerosis. However, the data on the association between LDL oxidation and severity of clinical manifestations of coronary artery disease (CAD) are contradictory. Previous reports were concerned mostly with unstable angina patients. The present study was undertaken to evaluate plasma lipid oxidation status in patients with stable CAD. DESIGN AND METHODS: 37 male patients with angiographically confirmed CAD (asymptomatic or suffering from stable angina pectoris) and 32 control subjects were used in the study. Plasma levels of vitamin E and products of lipid peroxidation, as well as parameters of the test for oxidizability of LDL in vitro were measured. RESULTS: We did not find differences between 2 groups of individuals regarding the levels of products of lipid peroxidation, vitamin E levels, lag time, maximal rate of oxidation, and total amount of conjugated dienes in the test for oxidizability of LDL. CONCLUSION: The results of our study challenge, but do not disprove, the oxidative hypothesis of atherosclerosis. Real atherosclerotic modifications of plasma LDL occur apparently in the vascular wall after trapping of LDL by the interstitial matrix. The rise in oxidative parameters in unstable angina reported in the literature may not be the cause of the disease but, rather, the consequence of the multiple brief episodes of ischemia-reperfusion. SN - 0009-9120 UR - https://www.unboundmedicine.com/medline/citation/8939406/Plasma_lipid_oxidation_and_susceptibility_of_low_density_lipoproteins_to_oxidation_in_male_patients_with_stable_coronary_artery_disease_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0009912096000720 DB - PRIME DP - Unbound Medicine ER -