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SIADH and other hyponatremic disorders: diagnosis and therapeutic problems.
Nihon Jinzo Gakkai Shi. 1996 Oct; 38(10):429-34.NJ

Abstract

Hyponatremia is more frequently observed in elderly patients associated with exaggerated response of ADH release and attenuated response of renin-aldosterone system. Differentiation of SIADH and hyponatremia other than SIADH is essential in anticipating the therapeutic effect of water restriction to correct hyponatremia. Serum concentration of uric acid and urinary excretion of kallikrein are significant parameters in biochemical discrimination index to differentiate these two types of hyponatremia. In addition to sodium replacement, water restriction and mineral corticoid, newly developed non-peptide ADH V2 receptor antagonist, OPC-31260, seems to be a useful tool to correct hyponatremia.

Authors+Show Affiliations

Department of Medicine, Jichi Medical School, Tochigi, Japan.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

8940823

Citation

Saito, T. "SIADH and Other Hyponatremic Disorders: Diagnosis and Therapeutic Problems." Nihon Jinzo Gakkai Shi, vol. 38, no. 10, 1996, pp. 429-34.
Saito T. SIADH and other hyponatremic disorders: diagnosis and therapeutic problems. Nihon Jinzo Gakkai Shi. 1996;38(10):429-34.
Saito, T. (1996). SIADH and other hyponatremic disorders: diagnosis and therapeutic problems. Nihon Jinzo Gakkai Shi, 38(10), 429-34.
Saito T. SIADH and Other Hyponatremic Disorders: Diagnosis and Therapeutic Problems. Nihon Jinzo Gakkai Shi. 1996;38(10):429-34. PubMed PMID: 8940823.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - SIADH and other hyponatremic disorders: diagnosis and therapeutic problems. A1 - Saito,T, PY - 1996/10/1/pubmed PY - 1996/10/1/medline PY - 1996/10/1/entrez SP - 429 EP - 34 JF - Nihon Jinzo Gakkai shi JO - Nihon Jinzo Gakkai Shi VL - 38 IS - 10 N2 - Hyponatremia is more frequently observed in elderly patients associated with exaggerated response of ADH release and attenuated response of renin-aldosterone system. Differentiation of SIADH and hyponatremia other than SIADH is essential in anticipating the therapeutic effect of water restriction to correct hyponatremia. Serum concentration of uric acid and urinary excretion of kallikrein are significant parameters in biochemical discrimination index to differentiate these two types of hyponatremia. In addition to sodium replacement, water restriction and mineral corticoid, newly developed non-peptide ADH V2 receptor antagonist, OPC-31260, seems to be a useful tool to correct hyponatremia. SN - 0385-2385 UR - https://www.unboundmedicine.com/medline/citation/8940823/SIADH_and_other_hyponatremic_disorders:_diagnosis_and_therapeutic_problems_ DB - PRIME DP - Unbound Medicine ER -