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A comparative trial of a single-dose ivermectin versus three days of albendazole for treatment of Strongyloides stercoralis and other soil-transmitted helminth infections in children.
Am J Trop Med Hyg. 1996 Nov; 55(5):477-81.AJ

Abstract

A randomized trial carried out in rural Zanzibar comparing a single dose of 200 micrograms/kg of ivermectin and 400 mg/day for three days of albendazole for treatment of strongyloidiasis and other intestinal nematodes is described. In 301 children with Strongyloides stercoralis infection, treatment with ivermectin or albendazole resulted in cure rates of 83% and 45%, respectively. While both drugs were very effective against Ascaris lumbricoides, Trichuris trichiura was cured only in 11% (ivermectin) and 43% (albendazole) of the subjects, although the mean eggload was reduced by 59% and 92%, respectively. Ivermectin was ineffective against hookworms, while albendazole resulted in a cure rate of 98%. No severe side effects were recorded and mild side effects were of transient nature for both treatments. Therefore, ivermectin provides a safe and a highly effective single dose treatment for S. stercoralis and A. lumbricoides, while it is not an alternative for the treatment of T. trichiura and hookworm infections.

Authors+Show Affiliations

Swiss Tropical Institute, Basel, Switzerland.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8940976

Citation

Marti, H, et al. "A Comparative Trial of a Single-dose Ivermectin Versus Three Days of Albendazole for Treatment of Strongyloides Stercoralis and Other Soil-transmitted Helminth Infections in Children." The American Journal of Tropical Medicine and Hygiene, vol. 55, no. 5, 1996, pp. 477-81.
Marti H, Haji HJ, Savioli L, et al. A comparative trial of a single-dose ivermectin versus three days of albendazole for treatment of Strongyloides stercoralis and other soil-transmitted helminth infections in children. Am J Trop Med Hyg. 1996;55(5):477-81.
Marti, H., Haji, H. J., Savioli, L., Chwaya, H. M., Mgeni, A. F., Ameir, J. S., & Hatz, C. (1996). A comparative trial of a single-dose ivermectin versus three days of albendazole for treatment of Strongyloides stercoralis and other soil-transmitted helminth infections in children. The American Journal of Tropical Medicine and Hygiene, 55(5), 477-81.
Marti H, et al. A Comparative Trial of a Single-dose Ivermectin Versus Three Days of Albendazole for Treatment of Strongyloides Stercoralis and Other Soil-transmitted Helminth Infections in Children. Am J Trop Med Hyg. 1996;55(5):477-81. PubMed PMID: 8940976.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A comparative trial of a single-dose ivermectin versus three days of albendazole for treatment of Strongyloides stercoralis and other soil-transmitted helminth infections in children. AU - Marti,H, AU - Haji,H J, AU - Savioli,L, AU - Chwaya,H M, AU - Mgeni,A F, AU - Ameir,J S, AU - Hatz,C, PY - 1996/11/1/pubmed PY - 1996/11/1/medline PY - 1996/11/1/entrez SP - 477 EP - 81 JF - The American journal of tropical medicine and hygiene JO - Am J Trop Med Hyg VL - 55 IS - 5 N2 - A randomized trial carried out in rural Zanzibar comparing a single dose of 200 micrograms/kg of ivermectin and 400 mg/day for three days of albendazole for treatment of strongyloidiasis and other intestinal nematodes is described. In 301 children with Strongyloides stercoralis infection, treatment with ivermectin or albendazole resulted in cure rates of 83% and 45%, respectively. While both drugs were very effective against Ascaris lumbricoides, Trichuris trichiura was cured only in 11% (ivermectin) and 43% (albendazole) of the subjects, although the mean eggload was reduced by 59% and 92%, respectively. Ivermectin was ineffective against hookworms, while albendazole resulted in a cure rate of 98%. No severe side effects were recorded and mild side effects were of transient nature for both treatments. Therefore, ivermectin provides a safe and a highly effective single dose treatment for S. stercoralis and A. lumbricoides, while it is not an alternative for the treatment of T. trichiura and hookworm infections. SN - 0002-9637 UR - https://www.unboundmedicine.com/medline/citation/8940976/A_comparative_trial_of_a_single_dose_ivermectin_versus_three_days_of_albendazole_for_treatment_of_Strongyloides_stercoralis_and_other_soil_transmitted_helminth_infections_in_children_ L2 - https://ajtmh.org/doi/10.4269/ajtmh.1996.55.477 DB - PRIME DP - Unbound Medicine ER -