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Pharmacokinetics of new antiepileptic drugs.
Epilepsia. 1996; 37 Suppl 6:S12-6.E

Abstract

This article surveys the pharmacokinetic parameters for the new antiepileptic drugs (AEDs): felbamate, gabapentin, lamotrigine, oxcarbazepine, tiagabine, topiramate, and vigabatrin. Compared to the pharmacokinetics of standard AEDs, these new AEDs have progressed in terms of (a) longer half-lives, permitting once- or twice-daily dosing, (b) greatly reduced potential for drug interactions, thus increasing ease of treatment, and (c) general lack of hepatic enzyme induction, which facilitates polytherapy as well as other aspects of treatment.

Authors+Show Affiliations

University Clinic of Neurology, Hvidovre Hospital, Denmark.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

8941037

Citation

Gram, L. "Pharmacokinetics of New Antiepileptic Drugs." Epilepsia, vol. 37 Suppl 6, 1996, pp. S12-6.
Gram L. Pharmacokinetics of new antiepileptic drugs. Epilepsia. 1996;37 Suppl 6:S12-6.
Gram, L. (1996). Pharmacokinetics of new antiepileptic drugs. Epilepsia, 37 Suppl 6, S12-6.
Gram L. Pharmacokinetics of New Antiepileptic Drugs. Epilepsia. 1996;37 Suppl 6:S12-6. PubMed PMID: 8941037.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pharmacokinetics of new antiepileptic drugs. A1 - Gram,L, PY - 1996/1/1/pubmed PY - 1996/1/1/medline PY - 1996/1/1/entrez SP - S12 EP - 6 JF - Epilepsia JO - Epilepsia VL - 37 Suppl 6 N2 - This article surveys the pharmacokinetic parameters for the new antiepileptic drugs (AEDs): felbamate, gabapentin, lamotrigine, oxcarbazepine, tiagabine, topiramate, and vigabatrin. Compared to the pharmacokinetics of standard AEDs, these new AEDs have progressed in terms of (a) longer half-lives, permitting once- or twice-daily dosing, (b) greatly reduced potential for drug interactions, thus increasing ease of treatment, and (c) general lack of hepatic enzyme induction, which facilitates polytherapy as well as other aspects of treatment. SN - 0013-9580 UR - https://www.unboundmedicine.com/medline/citation/8941037/Pharmacokinetics_of_new_antiepileptic_drugs_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0013-9580&date=1996&volume=37&issue=&spage=S12 DB - PRIME DP - Unbound Medicine ER -