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Increased risk of hepatocellular carcinoma in patients infected with hepatitis C genotype 1b.
Am J Gastroenterol. 1996 Dec; 91(12):2560-2.AJ

Abstract

Infection with hepatitis C virus (HCV) genotype 1b has been reported to be associated with more severe liver disease and an unfavorable outcome. Liver transplantation allows for a complete examination of the explanted liver for the detection of hepatocellular carcinoma (HCC).

OBJECTIVE

To study the prevalence of HCC in patients with liver cirrhosis secondary to chronic infection with HCV genotype 1b compared with those infected with other genotypes.

METHODS

Sera were collected from 48 consecutive patients undergoing liver transplantation for end stage liver disease secondary to HCV infection. RNA was extracted from serum using chaotropic lysis and isopropanol precipitation. Reverse transcriptase-polymerase chain reaction of the NS5 region was performed, followed by automated sequencing on desalted amplification products. Genotype assignment followed Simmonds's classification. All explanted livers were examined for the presence of HCC.

RESULTS

HCV genotypes in our patients were as follows: subtype 1a, 20 patients (42%); 1b, 18 patients (37.5%); 2a, one patient (2%); 2b, six patients (12.5%); 3a, one patient (2%); and 4a, two patients (4%). Although five of 18 patients infected with HCV genotype 1b (28%) had HCC, only one of 30 patients (3%) infected with all other genotypes (1a, 2a, 2b, 3a, and 4a) had HCC (p = 0.02).

CONCLUSION

Infection with HCV genotype 1b may carry a higher risk for the development of HCC than infection with other HCV genotypes.

Authors+Show Affiliations

Division of Gastroenterology, Mayo Clinic, Rochester, Minnesota 55905, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

8946986

Citation

Zein, N N., et al. "Increased Risk of Hepatocellular Carcinoma in Patients Infected With Hepatitis C Genotype 1b." The American Journal of Gastroenterology, vol. 91, no. 12, 1996, pp. 2560-2.
Zein NN, Poterucha JJ, Gross JB, et al. Increased risk of hepatocellular carcinoma in patients infected with hepatitis C genotype 1b. Am J Gastroenterol. 1996;91(12):2560-2.
Zein, N. N., Poterucha, J. J., Gross, J. B., Wiesner, R. H., Therneau, T. M., Gossard, A. A., Wendt, N. K., Mitchell, P. S., Germer, J. J., & Persing, D. H. (1996). Increased risk of hepatocellular carcinoma in patients infected with hepatitis C genotype 1b. The American Journal of Gastroenterology, 91(12), 2560-2.
Zein NN, et al. Increased Risk of Hepatocellular Carcinoma in Patients Infected With Hepatitis C Genotype 1b. Am J Gastroenterol. 1996;91(12):2560-2. PubMed PMID: 8946986.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Increased risk of hepatocellular carcinoma in patients infected with hepatitis C genotype 1b. AU - Zein,N N, AU - Poterucha,J J, AU - Gross,J B,Jr AU - Wiesner,R H, AU - Therneau,T M, AU - Gossard,A A, AU - Wendt,N K, AU - Mitchell,P S, AU - Germer,J J, AU - Persing,D H, PY - 1996/12/1/pubmed PY - 2001/3/28/medline PY - 1996/12/1/entrez SP - 2560 EP - 2 JF - The American journal of gastroenterology JO - Am. J. Gastroenterol. VL - 91 IS - 12 N2 - UNLABELLED: Infection with hepatitis C virus (HCV) genotype 1b has been reported to be associated with more severe liver disease and an unfavorable outcome. Liver transplantation allows for a complete examination of the explanted liver for the detection of hepatocellular carcinoma (HCC). OBJECTIVE: To study the prevalence of HCC in patients with liver cirrhosis secondary to chronic infection with HCV genotype 1b compared with those infected with other genotypes. METHODS: Sera were collected from 48 consecutive patients undergoing liver transplantation for end stage liver disease secondary to HCV infection. RNA was extracted from serum using chaotropic lysis and isopropanol precipitation. Reverse transcriptase-polymerase chain reaction of the NS5 region was performed, followed by automated sequencing on desalted amplification products. Genotype assignment followed Simmonds's classification. All explanted livers were examined for the presence of HCC. RESULTS: HCV genotypes in our patients were as follows: subtype 1a, 20 patients (42%); 1b, 18 patients (37.5%); 2a, one patient (2%); 2b, six patients (12.5%); 3a, one patient (2%); and 4a, two patients (4%). Although five of 18 patients infected with HCV genotype 1b (28%) had HCC, only one of 30 patients (3%) infected with all other genotypes (1a, 2a, 2b, 3a, and 4a) had HCC (p = 0.02). CONCLUSION: Infection with HCV genotype 1b may carry a higher risk for the development of HCC than infection with other HCV genotypes. SN - 0002-9270 UR - https://www.unboundmedicine.com/medline/citation/8946986/Increased_risk_of_hepatocellular_carcinoma_in_patients_infected_with_hepatitis_C_genotype_1b_ L2 - http://www.diseaseinfosearch.org/result/3332 DB - PRIME DP - Unbound Medicine ER -