Tags

Type your tag names separated by a space and hit enter

Effects of all-trans retinoic acid and sodium lauryl sulphate on the permeability of human skin in vitro.
Br J Dermatol. 1996 Sep; 135(3):428-32.BJ

Abstract

Recent in vivo investigations have shown that pretreatment with topical all-trans retinoic acid (RA) may diminish the skin response to sodium lauryl sulphate (SLS). This study evaluated the permeation of SLS through human skin after pretreatment with RA, and vice versa, by in vitro methods. The permeability coefficient of SLS (3.24 +/- 0.21 x 10(3) cm/h) and the 24-h cumulative amount of SLS (3.41 +/- 0.6% of dose applied) permeating RA-pretreated skin did not differ significantly from those across untreated skin (control) (P > 0.05). In contrast, the permeability coefficient of RA (0.23 +/- 0.05 x 10(3) cm/h) and its 24-h cumulative amount (0.37 +/- 0.05% of dose applied) penetrating SLS-pretreated skin were significantly greater than those permeating untreated skin (P < 0.05). Thus, an increase in RA penetration was induced by SLS pretreatment; however, pretreating the skin with RA did not inhibit the percutaneous permeation of SLS. Based on previous in vivo findings where RA reduced skin reactions to SLS, one would speculate that RA pretreatment may decrease SLS penetration. However, these penetration data do not necessarily uphold this presumption. Perhaps, other interactions between the substances and the skin, e.g. at cellular levels, may be responsible for the differing skin responses.

Links

Publisher Full Text
Aggregator Full Text

Authors+Show Affiliations

Effendy I
Department of Dermatology, University of Marburg, Germany.
Weltfriend S
No affiliation info available
Kwangsukstith C
No affiliation info available
Singh P
No affiliation info available
Maibach HI
No affiliation info available

MeSH

AdultDrug InteractionsHumansIn Vitro TechniquesKeratolytic AgentsMalePermeabilitySkinSkin AbsorptionSodium Dodecyl SulfateSurface-Active AgentsTretinoin

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8949438

Citation

Effendy, I, et al. "Effects of All-trans Retinoic Acid and Sodium Lauryl Sulphate On the Permeability of Human Skin in Vitro." The British Journal of Dermatology, vol. 135, no. 3, 1996, pp. 428-32.
Effendy I, Weltfriend S, Kwangsukstith C, et al. Effects of all-trans retinoic acid and sodium lauryl sulphate on the permeability of human skin in vitro. Br J Dermatol. 1996;135(3):428-32.
Effendy, I., Weltfriend, S., Kwangsukstith, C., Singh, P., & Maibach, H. I. (1996). Effects of all-trans retinoic acid and sodium lauryl sulphate on the permeability of human skin in vitro. The British Journal of Dermatology, 135(3), 428-32.
Effendy I, et al. Effects of All-trans Retinoic Acid and Sodium Lauryl Sulphate On the Permeability of Human Skin in Vitro. Br J Dermatol. 1996;135(3):428-32. PubMed PMID: 8949438.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of all-trans retinoic acid and sodium lauryl sulphate on the permeability of human skin in vitro. AU - Effendy,I, AU - Weltfriend,S, AU - Kwangsukstith,C, AU - Singh,P, AU - Maibach,H I, PY - 1996/9/1/pubmed PY - 1996/9/1/medline PY - 1996/9/1/entrez SP - 428 EP - 32 JF - The British journal of dermatology JO - Br J Dermatol VL - 135 IS - 3 N2 - Recent in vivo investigations have shown that pretreatment with topical all-trans retinoic acid (RA) may diminish the skin response to sodium lauryl sulphate (SLS). This study evaluated the permeation of SLS through human skin after pretreatment with RA, and vice versa, by in vitro methods. The permeability coefficient of SLS (3.24 +/- 0.21 x 10(3) cm/h) and the 24-h cumulative amount of SLS (3.41 +/- 0.6% of dose applied) permeating RA-pretreated skin did not differ significantly from those across untreated skin (control) (P > 0.05). In contrast, the permeability coefficient of RA (0.23 +/- 0.05 x 10(3) cm/h) and its 24-h cumulative amount (0.37 +/- 0.05% of dose applied) penetrating SLS-pretreated skin were significantly greater than those permeating untreated skin (P < 0.05). Thus, an increase in RA penetration was induced by SLS pretreatment; however, pretreating the skin with RA did not inhibit the percutaneous permeation of SLS. Based on previous in vivo findings where RA reduced skin reactions to SLS, one would speculate that RA pretreatment may decrease SLS penetration. However, these penetration data do not necessarily uphold this presumption. Perhaps, other interactions between the substances and the skin, e.g. at cellular levels, may be responsible for the differing skin responses. SN - 0007-0963 UR - https://www.unboundmedicine.com/medline/citation/8949438/Effects_of_all_trans_retinoic_acid_and_sodium_lauryl_sulphate_on_the_permeability_of_human_skin_in_vitro_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&amp;sid=nlm:pubmed&amp;issn=0007-0963&amp;date=1996&amp;volume=135&amp;issue=3&amp;spage=428 DB - PRIME DP - Unbound Medicine ER -